Low Power Radiofrequency-Induced Release of Small Molecules from Iron Oxide-Polymer Core-Shell Composite Nanoparticles

低功率射频诱导氧化铁-聚合物核壳复合纳米颗粒中小分子的释放

• 批准号: 447456398
• 负责人: Dr. Emilia Izak-Nau
• 金额: --
• 依托单位: DWI - Leibniz-Institut für Interaktive Materialien e.V.
• 依托单位国家: 德国
• 项目类别: WBP Position
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/447456398?language=en
• 关键词: Low; Power; Radiofrequency; Induced; Release

The overarching goal of the project is to establish a Radiofrequency (RF)-triggered small molecule release system based on a mechanicalagitation of polymer shells of RF-sensitive Fe3O4 NPs. Within the scope of this research project, this aim will be pursued by followingthree major objectives: Objective 1: Formation of iron oxidecore/ polymer-shell NPs of different size and polymer immobilization strategy as nanocarriers for different drugs/molecules. Objective 2: Understanding the mechanical response and stability of the polymer coating in response to RF. Objective 3: Investigation of the drug/molecule loading capacity and rate of drug/molecule release from the variety of prepared nanocarriers under applied RF.

该项目的总体目标是建立一个基于RF敏感的Fe 3 O 4纳米颗粒聚合物外壳的机械搅拌的RF触发小分子释放系统。在本研究项目的范围内，这一目标将通过以下三个主要目标来实现：目标1：形成不同尺寸的氧化铁核/聚合物壳纳米颗粒和聚合物固定化策略作为不同药物/分子的纳米载体。目的2：了解聚合物涂层对RF的机械响应和稳定性。目标三：研究在施加RF下从各种制备的纳米载体的药物/分子负载能力和药物/分子释放速率。