Collaborative Research: Experimental Calibration of the Isotopic Content of Marine Sulfate
合作研究:海洋硫酸盐同位素含量的实验校准
基本信息
- 批准号:1536559
- 负责人:
- 金额:$ 26.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-01 至 2018-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Collaborative Research: Experimental Calibration of the Isotopic Content of Marine SulfateAlexander BradleyID: 1536559Sulfur is an essential element to life, and its biogeochemical cycle is of interest to a broad range of scientific disciplines. A requirement for understanding the sulfur cycle involves revealing and quantifying the mechanisms by which microbes oxidize and reduce sulfur species. This can be done by tracing stable sulfur and oxygen isotopes. Enzymes play a key role in the cycling of sulfur, but the degree to which individual enzymes preferentially use specific oxygen isotopes (fractionation) is not known and prevents complete understanding of observed oxygen isotopes patterns in marine sulfate. This project will investigate isotope fractionation (oxygen and sulfur) associated with two key enzymes, which are involved in the metabolism of both sulfate reducing microbes and some sulfur oxidizing microbes. Resolving the influence of these enzymes on the isotopic composition of marine sulfate is important to stable isotope biogeochemistry and chemical oceanography. The project will serve as a vehicle to educate and train a postdoctoral researcher and undergraduate students, and will provide a teacher training opportunity in the investigators' labs to aid teachers in the design of student field trips and hands-on exercises for their students.The cycling of sulfur between its oxidized and reduced forms is a major determinant of the oxidation of organic matter in the oceans and underlying sediments, and microbes play a key role in the biogeochemical cycling of sulfur. One of the key tracers of microbial sulfur cycling involves measuring the distribution of stable isotopes among sulfur phases. A number of studies have shown that the stable oxygen isotope composition of sulfate is an informative way to investigate the sulfur cycle. Despite its utility, there are few direct constraints on how biology impacts the oxygen isotopes of sulfate. The goal of this project is to place quantitative constraints on the enzymatic oxygen isotope fractionation associated with microbial sulfate reduction. This project will involve in vitro investigations of the kinetic isotope fractionations associated with ATP sulfurylase and APS reductase, and incorporate the resulting data into an existing model for understanding isotope fractionation during sulfate reduction and its resulting influence on the isotopic composition of marine sulfate. These models will provide critical insight into the behavior of the sulfur cycle and evolution of marine chemistry over key timescales.
合作研究:海洋硫酸盐同位素含量的实验校准Alexander Bradley ID:1536559硫是生命的基本元素,其地球化学循环对广泛的科学学科感兴趣。理解硫循环的要求涉及揭示和量化微生物氧化和还原硫物质的机制。这可以通过追踪稳定的硫和氧同位素来实现。酶在硫的循环中起着关键作用,但个别酶优先使用特定氧同位素(分馏)的程度尚不清楚,这阻碍了对海洋硫酸盐中观察到的氧同位素模式的完全理解。本项目将研究与两种关键酶相关的同位素分馏(氧和硫),这两种酶参与硫酸盐还原微生物和一些硫氧化微生物的代谢。解决这些酶对海洋硫酸盐同位素组成的影响,对稳定同位素地球化学和化学海洋学具有重要意义。该项目将作为教育和培训博士后研究人员和本科生的工具,并将在研究人员的实验室提供教师培训机会,以帮助教师设计学生实地考察和学生动手练习。硫在氧化态和还原态之间的循环是海洋和底层沉积物中有机物氧化的主要决定因素,微生物在硫的地球化学循环中起着关键作用。微生物硫循环的关键示踪剂之一涉及测量硫相之间的稳定同位素分布。许多研究表明,硫酸盐的稳定氧同位素组成是研究硫循环的一种有用方法。尽管硫酸盐具有实用性,但生物学如何影响硫酸盐的氧同位素几乎没有直接的限制。本项目的目标是对与微生物硫酸盐还原相关的酶氧同位素分馏进行定量限制。该项目将涉及对与ATP硫酸化酶和APS还原酶相关的动力学同位素分馏的体外研究,并将所得数据纳入现有模型中,以了解硫酸盐还原过程中的同位素分馏及其对海洋硫酸盐同位素组成的影响。这些模型将提供关键洞察硫循环的行为和演变的海洋化学在关键的时间尺度。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Alexander Bradley其他文献
Clinical Outcomes and Survivorship of Lateral Unicompartmental Knee Arthroplasty: A Large Single Surgeon Cohort
- DOI:
10.1016/j.arth.2024.05.067 - 发表时间:
2024-11-01 - 期刊:
- 影响因子:
- 作者:
William Harkin;Steven Kurina;Alicia Berger;E. Bailey Terhune;Alexander Bradley;Vasili Karas;Richard A. Berger - 通讯作者:
Richard A. Berger
Alexander Bradley的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似国自然基金
Research on Quantum Field Theory without a Lagrangian Description
- 批准号:24ZR1403900
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
Cell Research
- 批准号:31224802
- 批准年份:2012
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research
- 批准号:31024804
- 批准年份:2010
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research (细胞研究)
- 批准号:30824808
- 批准年份:2008
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Research on the Rapid Growth Mechanism of KDP Crystal
- 批准号:10774081
- 批准年份:2007
- 资助金额:45.0 万元
- 项目类别:面上项目
相似海外基金
NSF-BSF: Collaborative Research: Solids and reactive transport processes in sewer systems of the future: modeling and experimental investigation
NSF-BSF:合作研究:未来下水道系统中的固体和反应性输送过程:建模和实验研究
- 批准号:
2134594 - 财政年份:2024
- 资助金额:
$ 26.98万 - 项目类别:
Standard Grant
NSF-BSF: Collaborative Research: Solids and reactive transport processes in sewer systems of the future: modeling and experimental investigation
NSF-BSF:合作研究:未来下水道系统中的固体和反应性输送过程:建模和实验研究
- 批准号:
2134747 - 财政年份:2024
- 资助金额:
$ 26.98万 - 项目类别:
Standard Grant
Collaborative Research: Effect of Vertical Accelerations on the Seismic Performance of Steel Building Components: An Experimental and Numerical Study
合作研究:垂直加速度对钢建筑构件抗震性能的影响:实验和数值研究
- 批准号:
2244696 - 财政年份:2023
- 资助金额:
$ 26.98万 - 项目类别:
Standard Grant
FRG: Collaborative Research: Variationally Stable Neural Networks for Simulation, Learning, and Experimental Design of Complex Physical Systems
FRG:协作研究:用于复杂物理系统仿真、学习和实验设计的变稳定神经网络
- 批准号:
2245111 - 财政年份:2023
- 资助金额:
$ 26.98万 - 项目类别:
Continuing Grant
Collaborative Research: High-velocity and long-displacement stick-slips: Experimental analogs of earthquake rupture and the seismic cycle
合作研究:高速和长位移粘滑运动:地震破裂和地震周期的实验模拟
- 批准号:
2240418 - 财政年份:2023
- 资助金额:
$ 26.98万 - 项目类别:
Continuing Grant
Collaborative Research: Experimental and computational constraints on the isotope fractionation of Mossbauer-inactive elements in mantle minerals
合作研究:地幔矿物中穆斯堡尔非活性元素同位素分馏的实验和计算约束
- 批准号:
2246686 - 财政年份:2023
- 资助金额:
$ 26.98万 - 项目类别:
Standard Grant
Collaborative Research: Understanding Acoustoplasticity through Multiscale Computational and In-Situ, Time-Resolved Experimental Approach
合作研究:通过多尺度计算和原位时间分辨实验方法了解声塑性
- 批准号:
2148678 - 财政年份:2023
- 资助金额:
$ 26.98万 - 项目类别:
Standard Grant
Collaborative Research: Enhancing Chemoselectivity and Efficiency Through Control of Axial Coordination in Rh(II) Complexes: An Experimental and Computational Approach
合作研究:通过控制 Rh(II) 配合物的轴向配位提高化学选择性和效率:实验和计算方法
- 批准号:
2247836 - 财政年份:2023
- 资助金额:
$ 26.98万 - 项目类别:
Standard Grant
Collaborative Research: HNDS-I:SweetPea: Automating the Implementation and Documentation of Unbiased Experimental Designs
合作研究:HNDS-I:SweetPea:自动化无偏实验设计的实施和记录
- 批准号:
2318548 - 财政年份:2023
- 资助金额:
$ 26.98万 - 项目类别:
Standard Grant
Collaborative Research: HNDS-I:SweetPea: Automating the Implementation and Documentation of Unbiased Experimental Designs
合作研究:HNDS-I:SweetPea:自动化无偏实验设计的实施和记录
- 批准号:
2318550 - 财政年份:2023
- 资助金额:
$ 26.98万 - 项目类别:
Standard Grant