Virtual Fields Methods for Soft Musculoskeletal Tissue Characterization and Model Validation
用于软肌肉骨骼组织表征和模型验证的虚拟场方法
基本信息
- 批准号:1537711
- 负责人:
- 金额:$ 42.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-01 至 2018-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Each year hundreds of thousands of people suffer soft tissue injuries. The mechanical properties of the tissues that are damaged are difficult to measure. It is very difficult to make a test specimen from a natural soft tissue because the pre-load in the tissue is lost when it is cut. In addition, the cutting process damages fibers that are essential to the properties. This project will create and apply a method that can measure the deformations of a soft tissue without cutting a specimen and without removing the natural preload. All of the stretch of the tissue is measured using an MRI (magnetic resonance imaging) method and the deformations are put into a mathematical model of the tissue to calculate the properties needed to understand how injury occurs. The project will be applied to the anterior cruciate ligament (or ACL) which is part of the knee. Damage or rupture of the ACL is the most common soft tissue injury in athletic individuals. Women are particularly susceptible to ACL injury with rates from 4-10 times that of men depending on which activity. This research will develop new technology for measuring soft tissue mechanical properties and apply it to the ACL. The developed methods will be applicable to other soft, preloaded tissues and also to MRI visible soft engineering materials.The mechanical properties of the anterior cruciate ligament (ACL) of the knee are particularly challenging to experimentally characterize; in its anatomically relevant state the ACL is twisted and at least one of its two bundles is partially extended regardless of knee flexion angle. This tissue is also mechanically non-linear, anisotropic, (poro)viscoelastic, and heterogeneous. Full-field displacement methods that provide two- and three- dimensional displacement information over a large surface can reduce the number of test geometries needed to characterize soft tissue, as information about anisotropy, heterogeneity, non-linearity, and even viscoelasticity is contained within the displacement fields. This work seeks to explore full-surface and full-volume imaging modalities with corresponding displacement field analyses as a means to characterize the ACL bundles under uniaxial loading. A constitutive model for the ACL based on the uniaxial loading will be implemented into an MRI-derived finite element framework for computational analysis of the ACL. This model will be validated by using it to predict the ACL response to anterior tibial translation (ATT), its primary failure deformation mode.
每年有成千上万的人遭受软组织损伤。 受损组织的机械性能难以测量。 从天然软组织制作测试样本非常困难,因为组织中的预载荷在切割时会丢失。 此外,切割过程会损坏对性能至关重要的纤维。 该项目将创建和应用一种方法,可以测量软组织的变形,而无需切割标本,也无需去除自然预载荷。 使用MRI(磁共振成像)方法测量组织的所有拉伸,并将变形放入组织的数学模型中,以计算了解损伤如何发生所需的属性。 该项目将应用于前交叉韧带(或ACL),这是膝盖的一部分。 ACL损伤或断裂是运动员最常见的软组织损伤。 女性特别容易受到ACL损伤,其发生率是男性的4-10倍,具体取决于哪种活动。 本研究将开发新的软组织力学性能测量技术,并将其应用于ACL。 所开发的方法将适用于其他软,预装组织,也MRI可见的软工程材料。膝关节前交叉韧带(ACL)的机械性能是特别具有挑战性的实验表征,在其解剖学相关的状态下,ACL是扭曲的,至少有一个其两束部分延长,无论膝关节屈曲角度。该组织也是机械非线性的、各向异性的、(多孔)粘弹性的和异质的。在大表面上提供二维和三维位移信息的全场位移方法可以减少表征软组织所需的测试几何形状的数量,因为关于各向异性、异质性、非线性、甚至粘弹性的信息包含在位移场中。这项工作旨在探索全表面和全容积成像模式与相应的位移场分析作为一种手段,以表征单轴载荷下的ACL束。基于单轴加载的ACL本构模型将被实施到MRI衍生的有限元框架中,用于ACL的计算分析。将通过使用该模型预测ACL对胫骨前平移(ATT)(其主要失效变形模式)的反应来验证该模型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ellen Arruda其他文献
Free vibration of thin, creased elastic plates: Optimization and scaling laws
- DOI:
10.1016/j.tws.2023.111393 - 发表时间:
2024-02-01 - 期刊:
- 影响因子:
- 作者:
Avinkrishnan Vijayachandran;Othman Oudghiri-Idrissi;Hrishikesh Danawe;Xiaoming Mao;Ellen Arruda;Serife Tol;Anthony M. Waas - 通讯作者:
Anthony M. Waas
Ellen Arruda的其他文献
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{{ truncateString('Ellen Arruda', 18)}}的其他基金
Model Development for Soft Tissue Biomechanics by Full-Field Characterization and Variational System Identification
通过全场表征和变分系统识别进行软组织生物力学模型开发
- 批准号:
2211346 - 财政年份:2022
- 资助金额:
$ 42.95万 - 项目类别:
Standard Grant
Biomicromechanics of Heart Muscle Tissue Function
心肌组织功能的生物微观力学
- 批准号:
0200340 - 财政年份:2002
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$ 42.95万 - 项目类别:
Continuing Grant
Biomicromechanics of Stress-Assisted In-vitro Engineered Skin and Wound Remodeling
应力辅助体外工程皮肤和伤口重塑的生物微力学
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9988693 - 财政年份:2000
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$ 42.95万 - 项目类别:
Standard Grant
CAREER: Faculty Early Career Development Program
职业:教师早期职业发展计划
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9702884 - 财政年份:1997
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$ 42.95万 - 项目类别:
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Non Isothermal Analytical and Experimental Study of Viscoelastic Fiber Drawing
粘弹性纤维拉伸的非等温分析与实验研究
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RIA: Synthesis, Experimental Test and Constitutive Modelling of Elastomeric Networks Having Statistically Well-Defined Structures and Defect Structures
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9410564 - 财政年份:1994
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Proof of Principal Study of the Use of Orientation Parameters Measured by Polarized Flourescence as Internal Variables in Constitutive Models of Amorphous Networks
使用偏振荧光测量的取向参数作为非晶网络本构模型中的内部变量的主要研究证明
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$ 42.95万 - 项目类别:
Standard Grant
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