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Magnetic Resonance Line Shape of Water as a Probe of the Structure of Biological Tissue

作为生物组织结构样本的水的磁共振线形状

基本信息

批准号：
222108118
负责人：
Professor Dr. Valerij Kiselev, Ph.D.
金额：
--
依托单位：
Arbeitsbereich Medizinphysik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2012
资助国家：
德国
起止时间：
2011-12-31 至 2014-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/222108118?language=en
关键词：
Magnetic Resonance Line Shape Water

项目摘要

The NMR line shape of water in magnetically heterogeneous tissues is known to deviate from the Lorentzian shape. A novel description was proposed recently using the effective medium theory, which has been originally developed within condensed matter physics to describe transport in disordered media. The central quantity in this description is the self-energy part of the medium- averaged propagator. In the present MRI context, it can be interpreted as a transverse relaxation rate that depends on the frequency in the spectral domain. This dependence can be used as a probe of tissue structure yielding its characteristic correlation length and a measure of the dis- order strength. The first application to blood water spectroscopy demonstrated the potential of the method. The present project aims at using this potential to develop and verify methods for investigating cell-related heterogeneous magnetic structure in vivo. The method will be developed and optimized in blood as a relative simple and well studied system. The method will then be extended for measurements in suspensions of other cell species. First pilot applications of the method would be characterisation of tumour cellular structure in animal model and detection of parameters of the ferritin distribution in the normal human brain. These applications are aimed at exploiting the method potential and motivating future studies.

磁非均质组织中水的核磁共振谱线形状偏离洛伦兹形状。有效介质理论最初是在凝聚态物理中发展起来的，用于描述无序介质中的输运，最近提出了一种新的描述方法。这个描述中的中心量是介质平均传播器的自能部分。在目前的MRI背景下，它可以被解释为依赖于谱域频率的横向弛豫率。这种依赖性可以用作组织结构的探针，产生其特征相关长度和测量无序强度。首次应用于血水光谱显示了该方法的潜力。目前的项目旨在利用这种潜力来开发和验证研究体内细胞相关的异质磁结构的方法。该方法将在血液中作为一个相对简单和充分研究的系统进行开发和优化。然后，该方法将扩展到其他细胞种类的悬浮液的测量。该方法的第一个试点应用将是动物模型中肿瘤细胞结构的表征和正常人脑中铁蛋白分布参数的检测。这些应用旨在挖掘该方法的潜力，促进未来的研究。