SBIR Phase I: A Miniaturized Spectral Imaging Sensor for Biomedical Diagnostics

SBIR 第一阶段：用于生物医学诊断的小型化光谱成像传感器

• 批准号: 1548568
• 负责人: Russell Barbour
• 金额: $ 14.95万
• 依托单位: Advanced Microcavity Sensors LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1548568&HistoricalAwards=false
• 关键词: SBIR; Phase; Miniaturized; Spectral; Imaging

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is in the commercial market space known as hyperspectral imaging. The products that result from this project will have applications in many important industries for identifying and characterizing materials and tissues through their unique spectral (color) characteristics. One important application is biomedical imaging, for example in the early detection of skin cancer. Early detection (and excision) of melanoma is the only effective treatment. Survival decreases 20-fold and treatment costs increase 100-fold from earliest to latest stage, and misdiagnosis is a leading factor in malpractice suits that also increases the overall cost of healthcare. The research and development performed on this Small Business Innovation Research (SBIR) Phase I project will be key to the development of a novel optical filter based approach to hyperspectral imaging. This technology will allow for an affordable diagnostic tool for accurate, early detection of skin cancer and other medical conditions. There is also strong demand for a robust and high performance-to-cost ratio spectral imaging sensors in many other industries and applications including: pharmaceutical manufacturing, geographical imaging and remote sensing, analyzing mineral and chemical specimens, and currency or drug counterfeit detection.The proposed project will address engineering, manufacturing, and calibration challenges of a high performance-to-cost ratio hyperspectral imaging system. This technology bypasses the limitations of existing commercial spectral imaging technology with a dramatically different approach. The technology aims to utilize established wafer-based fabrication technology to integrate large arrays of curved-mirror microcavities as high finesse tunable filters in a compact and low cost-of-manufacture hyperspectral imaging sensor. The proposed project will address potential scalability of manufacturing the concave micro-mirrors, investigate the optical characteristics of the system for optimal performance, and compare our device with competing technologies in the field of biomedical spectral imaging. The project will develop the electrical control, data acquisition, and calibration techniques required to build a fully operational prototype. Improvement to the laser based fabrication process of the curved micro-mirrors will be researched in this project. The work plan is designed to investigate these key components, subsystems, and fabrication to determine feasibility by carrying out experimental investigations into each potential hurdle. The technology approach offers an attractive solution to realizing a state-of-the-art spectral imaging device that improves the performance-to-cost ratio, size and weight, and spectral resolution for a diverse set of applications.

这项小型企业创新研究（SBIR）I期项目的更广泛的影响/商业潜力在商业市场空间中，称为高光谱成像。该项目产生的产品将在许多重要行业中应用，以通过其独特的光谱（颜色）特征来识别和表征材料和组织。一种重要的应用是生物医学成像，例如在皮肤癌的早期检测中。黑色素瘤的早期检测（和切除）是唯一有效的治疗方法。生存降低了20倍，治疗成本从最早到最新阶段增加了100倍，误诊是渎职套件的主要因素，这也增加了医疗保健的总体成本。在这项小型企业创新研究（SBIR）I期项目上进行的研究与发展将是开发基于新型光学滤镜的高光谱成像方法的关键。该技术将允许使用负担得起的诊断工具，以便早期发现皮肤癌和其他医疗状况。在许多其他行业和应用中，对强劲且高性能比率的光谱传感器的需求也有很强的需求，包括：制药制造，地理成像和遥感，分析矿物质和化学样本，以及货币或药物伪造的检测。项目的项目将解决高级级别的高级级别的型号，以解决工程，制造业和校准。该技术绕过了现有的商业光谱成像技术的局限性，其方法截然不同。该技术旨在利用既定的基于晶圆的制造技术将大量弯曲的微腔阵列纳入紧凑型和低型制造成本的高光谱成本成像传感器中。拟议的项目将解决制造凹形微型效果的潜在可扩展性，研究系统的光学特性以进行最佳性能，并将我们的设备与生物医学光谱成像领域的竞争技术进行比较。该项目将开发构建完全运行原型所需的电气控制，数据采集和校准技术。该项目将研究基于激光的曲面微型摩擦的基于激光的制造过程。该工作计划旨在研究这些关键组成部分，子系统和制造，以通过对每个潜在障碍进行实验研究来确定可行性。该技术方法为实现最先进的光谱成像设备提供了一种有吸引力的解决方案，该设备可改善性能与成本比，大小和权重以及光谱分辨率以及各种应用程序集的光谱分辨率。