CAREER: SusChEM: Nickel Catalyzed Arylation: Reaction Development and Mechanistic Investigation

职业：SusChEM：镍催化芳基化：反应开发和机理研究

• 批准号: 1554630
• 负责人: Dipannita Kalyani
• 金额: $ 40万
• 依托单位: Saint Olaf College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1554630&HistoricalAwards=false
• 关键词: CAREER; SusChEM; Nickel; Catalyzed; Arylation

In this CAREER project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Kalyani of the Department of Chemistry at St. Olaf College is developing Ni-catalyzed methods to construct biaryl bonds. Biaryls are used for numerous commercial applications. New carbon-carbon bond forming reactions using readily available, inexpensive and/or renewable substrates and earth abundant Ni-catalysts are being developed. These studies may ultimately contribute to the design of more economical and greener processes for the production of compounds prevalent in pharmaceutical, agrochemical and material science industries. St. Olaf undergraduate researchers benefit from a state-of-the-art experience in organometallic catalysis, a possible prelude to careers at national labs, employment in the chemical or pharmaceutical industry, or faculty appointments. The research program strengthening the scientific work force. In addition, Professor Kalyani has designed a course to introduce non-science students to science by addressing global economic and sustainability challenges. Finally, in collaboration with the St. Olaf College Upward Bound Program for high school students, outreach activities introduce minority and disadvantaged students to the exciting world of organometallic chemistry in our everyday lives.Transition metal catalyzed methods for the construction of biaryl compounds are well-established. However, the vast majority of these methods use expensive precious-metal catalysts such as palladium and rhodium. Furthermore, aryl halides are the most common coupling partners employed for these reactions, and their use leads to environmentally undesirable halide wastes. Professor Kalyani's research program addresses these limitations through the use of earth-abundant nickel (Ni)-catalysts and non-halide aryl sources. The insights gained from the mechanistic studies may be helpful in the design of versatile new Ni-catalyzed reactions capable of activating carbon (C)-hydrogen (H), C-oxygen (O) and C-C bonds. Both high school and college students participate in Professor Kalyani's research project, where they are introduced to chemistry and develop a sound foundation to conduct, interpret, and communicate scientific research.

在这个由化学部化学催化计划资助的CAREER项目中，圣奥拉夫学院化学系的Kalyani教授正在开发Ni催化的方法来构建联芳基键。联芳基化合物用于许多商业应用。正在开发使用容易获得的、廉价的和/或可再生的底物和地球丰富的Ni催化剂的新的碳-碳键形成反应。这些研究可能最终有助于设计更经济和更环保的工艺，用于生产制药，农业化学和材料科学行业中流行的化合物。圣奥拉夫本科研究人员受益于有机金属催化的最先进的经验，在国家实验室的职业生涯，在化学或制药行业就业，或教师任命可能的前奏。加强科学工作队伍的研究计划。此外，Kalyani教授还设计了一门课程，通过应对全球经济和可持续发展挑战，向非理科学生介绍科学。最后，我们与圣奥拉夫学院的高中生向上拓展计划合作，开展外展活动，向少数民族和弱势学生介绍我们日常生活中令人兴奋的有机金属化学世界。过渡金属催化的联芳基化合物的构建方法已经建立。然而，这些方法中的绝大多数使用昂贵的贵金属催化剂，如钯和铑。此外，芳基卤化物是用于这些反应的最常见的偶联配体，并且它们的使用导致环境上不期望的卤化物废物。Kalyani教授的研究计划通过使用地球上丰富的镍（Ni）催化剂和非卤化物芳基来源来解决这些限制。从机理研究中获得的见解可能有助于设计能够活化碳（C）-氢（H），碳-氧（O）和C-C键的多功能新型Ni催化反应。高中生和大学生都参加了Kalyani教授的研究项目，在那里他们被介绍给化学，并建立了良好的基础来进行，解释和交流科学研究。