CAREER: SusChEM: Nickel Catalyzed Arylation: Reaction Development and Mechanistic Investigation

在这个由化学系化学催化计划资助的职业项目中，圣奥拉夫学院化学系的卡利亚尼教授正在开发镍催化的方法来构建联芳键。联芳烃被用于许多商业用途。人们正在开发新的碳-碳键形成反应，使用容易获得的、廉价的和/或可再生的底物和富含稀土的镍催化剂。这些研究最终可能有助于设计更经济、更绿色的工艺来生产在制药、农业化学和材料科学行业中普遍存在的化合物。圣奥拉夫大学的本科生研究人员受益于在有机金属催化方面的最先进经验，可能是在国家实验室工作的前奏，在化学或制药行业的就业，或教师任命。研究计划加强了科学工作力量。此外，卡利亚尼教授还设计了一门课程，通过应对全球经济和可持续发展挑战，向非理科学生介绍科学。最后，与圣奥拉夫学院高中生向上跳跃计划合作，外展活动向少数族裔和弱势学生介绍我们日常生活中令人兴奋的有机金属化学世界。过渡金属催化的方法构建联芳化合物是公认的。然而，这些方法中的绝大多数都使用昂贵的贵金属催化剂，如钯和铑。此外，芳基卤化物是这些反应中最常见的偶联伙伴，它们的使用导致了环境上不受欢迎的卤化物废物。Kalyani教授的研究计划通过使用富含地球的镍(Ni)催化剂和非卤代芳烃来源来解决这些限制。从机理研究中获得的见解可能有助于设计能够激活碳(C)-氢(H)、C-氧(O)和C-C键的新型镍催化反应。高中生和大学生都参与了卡利亚尼教授的研究项目，在那里他们被介绍给化学，并为进行、解释和交流科学研究奠定了坚实的基础。

In this CAREER project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Kalyani of the Department of Chemistry at St. Olaf College is developing Ni-catalyzed methods to construct biaryl bonds. Biaryls are used for numerous commercial applications. New carbon-carbon bond forming reactions using readily available, inexpensive and/or renewable substrates and earth abundant Ni-catalysts are being developed. These studies may ultimately contribute to the design of more economical and greener processes for the production of compounds prevalent in pharmaceutical, agrochemical and material science industries. St. Olaf undergraduate researchers benefit from a state-of-the-art experience in organometallic catalysis, a possible prelude to careers at national labs, employment in the chemical or pharmaceutical industry, or faculty appointments. The research program strengthening the scientific work force. In addition, Professor Kalyani has designed a course to introduce non-science students to science by addressing global economic and sustainability challenges. Finally, in collaboration with the St. Olaf College Upward Bound Program for high school students, outreach activities introduce minority and disadvantaged students to the exciting world of organometallic chemistry in our everyday lives.Transition metal catalyzed methods for the construction of biaryl compounds are well-established. However, the vast majority of these methods use expensive precious-metal catalysts such as palladium and rhodium. Furthermore, aryl halides are the most common coupling partners employed for these reactions, and their use leads to environmentally undesirable halide wastes. Professor Kalyani's research program addresses these limitations through the use of earth-abundant nickel (Ni)-catalysts and non-halide aryl sources. The insights gained from the mechanistic studies may be helpful in the design of versatile new Ni-catalyzed reactions capable of activating carbon (C)-hydrogen (H), C-oxygen (O) and C-C bonds. Both high school and college students participate in Professor Kalyani's research project, where they are introduced to chemistry and develop a sound foundation to conduct, interpret, and communicate scientific research.