CAREER: SusChEM: Nickel Catalyzed Arylation: Reaction Development and Mechanistic Investigation

在这个由化学部化学催化项目资助的CAREER项目中，圣奥拉夫学院化学系的Kalyani教授正在开发镍催化方法来构建联芳基键。双芳烃有许多商业用途。新的碳-碳键形成反应使用容易获得，廉价和/或可再生的底物和地球丰富的镍催化剂正在开发。这些研究可能最终有助于设计更经济、更环保的工艺，用于生产在制药、农用化学和材料科学工业中普遍存在的化合物。圣奥拉夫大学的本科研究人员受益于最先进的有机金属催化经验，这可能是在国家实验室工作、在化学或制药行业就业或教师任命的前奏。加强科研队伍建设的研究计划。此外，Kalyani教授还设计了一门课程，通过解决全球经济和可持续性挑战，向非理科生介绍科学。最后，与圣奥拉夫学院高中生向上发展计划合作，向少数民族和弱势学生介绍日常生活中令人兴奋的有机金属化学世界。过渡金属催化构建联芳基化合物的方法已经建立。然而，这些方法中绝大多数使用昂贵的贵金属催化剂，如钯和铑。此外，芳基卤化物是用于这些反应的最常见的偶联伙伴，它们的使用导致对环境不利的卤化物废物。Kalyani教授的研究项目通过使用地球上丰富的镍（Ni）催化剂和非卤化物芳基源来解决这些限制。从机理研究中获得的见解可能有助于设计多功能的新型镍催化反应，能够激活碳(C)-氢(H)， C-氧(O)和C-C键。高中生和大学生都参加了Kalyani教授的研究项目，在那里他们被引入化学，并为进行、解释和交流科学研究奠定了良好的基础。

In this CAREER project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Kalyani of the Department of Chemistry at St. Olaf College is developing Ni-catalyzed methods to construct biaryl bonds. Biaryls are used for numerous commercial applications. New carbon-carbon bond forming reactions using readily available, inexpensive and/or renewable substrates and earth abundant Ni-catalysts are being developed. These studies may ultimately contribute to the design of more economical and greener processes for the production of compounds prevalent in pharmaceutical, agrochemical and material science industries. St. Olaf undergraduate researchers benefit from a state-of-the-art experience in organometallic catalysis, a possible prelude to careers at national labs, employment in the chemical or pharmaceutical industry, or faculty appointments. The research program strengthening the scientific work force. In addition, Professor Kalyani has designed a course to introduce non-science students to science by addressing global economic and sustainability challenges. Finally, in collaboration with the St. Olaf College Upward Bound Program for high school students, outreach activities introduce minority and disadvantaged students to the exciting world of organometallic chemistry in our everyday lives.Transition metal catalyzed methods for the construction of biaryl compounds are well-established. However, the vast majority of these methods use expensive precious-metal catalysts such as palladium and rhodium. Furthermore, aryl halides are the most common coupling partners employed for these reactions, and their use leads to environmentally undesirable halide wastes. Professor Kalyani's research program addresses these limitations through the use of earth-abundant nickel (Ni)-catalysts and non-halide aryl sources. The insights gained from the mechanistic studies may be helpful in the design of versatile new Ni-catalyzed reactions capable of activating carbon (C)-hydrogen (H), C-oxygen (O) and C-C bonds. Both high school and college students participate in Professor Kalyani's research project, where they are introduced to chemistry and develop a sound foundation to conduct, interpret, and communicate scientific research.