CAREER: Rhodium-Catalyzed Oxidative Functionalization Reactions

职业：铑催化的氧化官能化反应

• 批准号: 1555337
• 负责人: Kami Hull
• 金额: $ 67.5万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1555337&HistoricalAwards=false
• 关键词: CAREER; Rhodium; Catalyzed; Oxidative; Functionalization

The Chemical Catalysis Program of the Chemistry Division supports the research of Professor Kami L. Hull of the University of Illinois, Urbana-Champaign to develop new approaches for the synthesis of carbonyl containing compounds. Such species are extremely important in the commodity chemical industry as well as in pharmaceutical and specialty chemical syntheses. Their preparations, however, are complicated and often involve the production of undesirable by-products. One of the primary goals of this project is to maximize the economy of the synthesis of these species. The development of new methodologies that minimize waste are targeted for the synthesis of amides, esters, thioesters, and ketones, all of which are important starting materials or intermediates in large scale chemical processes. The broader impacts this work include the potential to minimize the waste associated with the synthesis of carbonyl compounds, thereby making better use of our natural resources in the synthesis of fine and commodity chemicals. Additionally, there is an outreach component that aims to increase the scientific literacy of rural children and encourage these students to pursue higher education in STEM disciplines.New rhodium based metal-catalysts are developed that allow for the direct coupling of alcohols and nucleophiles, through dehydrogenation or transfer hydrogenation, for the synthesis of amides, esters, thioesters and ketones. Further, synthesis of alpha and beta chiral carbonyl compounds is explored. The catalysts and organic products are fully characterized by NMR spectroscopy, IR spectroscopy, and X-ray crystallography, when needed. To increase the scientific understanding of the greater community, an outreach program entitled Next Generation of Illinois Scientists (NGIS) is developed. The goals of NGIS is to bring scientific outreach to rural communities. Working with fourth grade students at rural elementary schools within a 50 mile radius of the University of Illinois, Urbana-Champaign a series of experiments is developed that builds on the Common Core Curriculum.

化学部的化学催化项目支持伊利诺伊大学厄巴纳-香槟分校 Kami L. Hull 教授的研究，开发合成含羰基化合物的新方法。这些物种在商品化学工业以及制药和特种化学合成中极其重要。然而，它们的制备过程很复杂，并且常常会产生不需要的副产物。该项目的主要目标之一是最大限度地提高这些物种合成的经济性。开发最大限度减少废物的新方法的目标是合成酰胺、酯、硫酯和酮，所有这些都是大规模化学过程中重要的起始材料或中间体。这项工作的更广泛影响包括最大限度地减少与羰基化合物合成相关的废物的潜力，从而在精细化学品和商品化学品的合成中更好地利用我们的自然资源。此外，还有一个外展部分旨在提高农村儿童的科学素养，并鼓励这些学生接受 STEM 学科的高等教育。开发了新型铑基金属催化剂，允许醇和亲核试剂通过脱氢或转移氢化直接偶联，合成酰胺、酯、硫酯和酮。此外，还探索了α和β手性羰基化合物的合成。必要时，可以通过 NMR 光谱、IR 光谱和 X 射线晶体学对催化剂和有机产物进行全面表征。为了增进广大社区对科学的了解，制定了一项名为“下一代伊利诺伊州科学家”(NGIS) 的外展计划。 NGIS 的目标是将科学推广到农村社区。与伊利诺伊大学厄巴纳-香槟分校 50 英里半径内的农村小学的四年级学生合作，开发了一系列以共同核心课程为基础的实验。