CAREER: Rhodium-Catalyzed Oxidative Functionalization Reactions

职业：铑催化的氧化官能化反应

• 批准号: 1555337
• 负责人: Kami Hull
• 金额: $ 67.5万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1555337&HistoricalAwards=false
• 关键词: CAREER; Rhodium; Catalyzed; Oxidative; Functionalization

The Chemical Catalysis Program of the Chemistry Division supports the research of Professor Kami L. Hull of the University of Illinois, Urbana-Champaign to develop new approaches for the synthesis of carbonyl containing compounds. Such species are extremely important in the commodity chemical industry as well as in pharmaceutical and specialty chemical syntheses. Their preparations, however, are complicated and often involve the production of undesirable by-products. One of the primary goals of this project is to maximize the economy of the synthesis of these species. The development of new methodologies that minimize waste are targeted for the synthesis of amides, esters, thioesters, and ketones, all of which are important starting materials or intermediates in large scale chemical processes. The broader impacts this work include the potential to minimize the waste associated with the synthesis of carbonyl compounds, thereby making better use of our natural resources in the synthesis of fine and commodity chemicals. Additionally, there is an outreach component that aims to increase the scientific literacy of rural children and encourage these students to pursue higher education in STEM disciplines.New rhodium based metal-catalysts are developed that allow for the direct coupling of alcohols and nucleophiles, through dehydrogenation or transfer hydrogenation, for the synthesis of amides, esters, thioesters and ketones. Further, synthesis of alpha and beta chiral carbonyl compounds is explored. The catalysts and organic products are fully characterized by NMR spectroscopy, IR spectroscopy, and X-ray crystallography, when needed. To increase the scientific understanding of the greater community, an outreach program entitled Next Generation of Illinois Scientists (NGIS) is developed. The goals of NGIS is to bring scientific outreach to rural communities. Working with fourth grade students at rural elementary schools within a 50 mile radius of the University of Illinois, Urbana-Champaign a series of experiments is developed that builds on the Common Core Curriculum.

化学部的化学催化计划支持乌尔巴纳·坎普尼（Urbana-Champaign）伊利诺伊大学的卡米·赫尔（Kami L.这种物种在商品化学工业以及药物和特种化学合成中都非常重要。但是，他们的准备工作很复杂，通常涉及不良副产品的产生。该项目的主要目标之一是最大化这些物种合成的经济。最小化废物的新方法的发展是针对酰胺，酯，硫代蛋白和酮的合成的，所有这些方法都是在大规模化学过程中的重要起始材料或中间体。这项工作更广泛的影响包括最大程度地减少与羰基化合物合成相关的废物的潜力，从而更好地利用我们的自然资源在综合细和商品化学品中。 Additionally, there is an outreach component that aims to increase the scientific literacy of rural children and encourage these students to pursue higher education in STEM disciplines.New rhodium based metal-catalysts are developed that allow for the direct coupling of alcohols and nucleophiles, through dehydrogenation or transfer hydrogenation, for the synthesis of amides, esters, thioesters and ketones.此外，还探索了α和β手性羰基化合物的合成。催化剂和有机产物在需要时以NMR光谱，红外光谱和X射线晶体学的充分特征。为了提高对更大社区的科学理解，开发了一个名为下一代伊利诺伊州科学家（NGIS）的外展计划。 NGIS的目标是将科学宣传给农村社区。在伊利诺伊大学50英里半径内的农村小学的四年级学生中，乌尔巴纳·坎佩恩（Urbana-Champaign）一系列实验是建立在公共核心课程的基础上的。