CAREER: Rhodium-Catalyzed Oxidative Functionalization Reactions

化学系的化学催化计划支持伊利诺伊大学厄巴纳-香槟分校的卡米·L·赫尔教授的研究，以开发合成含有羰基化合物的新方法。这类物种在商品化学工业以及制药和特种化学合成中极其重要。然而，他们的准备工作很复杂，往往涉及生产不受欢迎的副产品。该项目的主要目标之一是最大限度地提高这些物种合成的经济性。最大限度减少浪费的新方法的开发目标是合成酰胺、酯、硫代酯和酮，所有这些都是大规模化学过程中的重要起始原料或中间体。这项工作的更广泛影响包括有可能最大限度地减少与合成羰基化合物有关的废物，从而更好地利用我们的自然资源来合成精细化学品和商品化学品。此外，还有一个推广部分，旨在提高农村儿童的科学素养，鼓励这些学生接受STEM学科的高等教育。开发了新的铑基金属催化剂，允许醇和亲核试剂通过脱氢或转移氢化直接偶联，用于合成酰胺、酯、硫酸酯和酮。此外，还对α和β手性羰基化合物的合成进行了探索。需要时，催化剂和有机产品通过核磁共振光谱、红外光谱和X射线结晶学进行了充分的表征。为了增加对更大社区的科学理解，开发了一个名为下一代伊利诺伊州科学家(NGIS)的外联计划。NGIS的目标是将科学推广到农村社区。与伊利诺伊大学厄巴纳-香槟分校方圆50英里范围内农村小学的四年级学生合作，在共同核心课程的基础上开发了一系列实验。

The Chemical Catalysis Program of the Chemistry Division supports the research of Professor Kami L. Hull of the University of Illinois, Urbana-Champaign to develop new approaches for the synthesis of carbonyl containing compounds. Such species are extremely important in the commodity chemical industry as well as in pharmaceutical and specialty chemical syntheses. Their preparations, however, are complicated and often involve the production of undesirable by-products. One of the primary goals of this project is to maximize the economy of the synthesis of these species. The development of new methodologies that minimize waste are targeted for the synthesis of amides, esters, thioesters, and ketones, all of which are important starting materials or intermediates in large scale chemical processes. The broader impacts this work include the potential to minimize the waste associated with the synthesis of carbonyl compounds, thereby making better use of our natural resources in the synthesis of fine and commodity chemicals. Additionally, there is an outreach component that aims to increase the scientific literacy of rural children and encourage these students to pursue higher education in STEM disciplines.New rhodium based metal-catalysts are developed that allow for the direct coupling of alcohols and nucleophiles, through dehydrogenation or transfer hydrogenation, for the synthesis of amides, esters, thioesters and ketones. Further, synthesis of alpha and beta chiral carbonyl compounds is explored. The catalysts and organic products are fully characterized by NMR spectroscopy, IR spectroscopy, and X-ray crystallography, when needed. To increase the scientific understanding of the greater community, an outreach program entitled Next Generation of Illinois Scientists (NGIS) is developed. The goals of NGIS is to bring scientific outreach to rural communities. Working with fourth grade students at rural elementary schools within a 50 mile radius of the University of Illinois, Urbana-Champaign a series of experiments is developed that builds on the Common Core Curriculum.