The molecular identity, function, and epilepsy-related plasticity of voltage- and calcium-dependent potassium channels in dentate gyrus granule cells of mice and humans.

小鼠和人类齿状回颗粒细胞中电压和钙依赖性钾通道的分子特性、功能和癫痫相关可塑性。

• 批准号: 222858180
• 负责人: Dr. Jakob Wolfart
• 金额: --
• 依托单位: Gastprofessur für Physiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/222858180?language=en
• 关键词: molecular; identity; function; epilepsy; related

We will determine the molecular identity, function, and epilepsy-related plasticity of voltage- and calcium-dependent potassium channels of dentate gyrus granule cells. To this end we will use electrophysiological and molecular biology techniques. Hippocampal tissue of humans obtained during epilepsy surgery and epilepsy animal models will be employed. Using conductance-based computer simulations, we will precisely dissect the functional impact of identified potassium channels under physiological and pathophysiological conditions.

我们将确定齿状回颗粒细胞的电压和钙依赖性钾通道的分子特性、功能和癫痫相关的可塑性。为此，我们将使用电生理学和分子生物学技术。将使用在癫痫手术期间获得的人海马组织和癫痫动物模型。使用基于电导的计算机模拟，我们将精确地剖析在生理和病理生理条件下识别的钾通道的功能影响。

项目成果

Intrinsic rescaling of granule cells restores pattern separation ability of a dentate gyrus network model during epileptic hyperexcitability

颗粒细胞的内在重新缩放恢复了癫痫过度兴奋期间齿状回网络模型的模式分离能力

• DOI: 10.1002/hipo.22373
• 发表时间: 2015
• 期刊: Hippocampus
• 影响因子: 3.5
• 作者: Yim MY;Hanuschkin A;Wolfart J
• 通讯作者: Wolfart J

Homeostasis of Neuronal Excitability Via Synaptic and Intrinsic Inhibitory Mechanisms

通过突触和内在抑制机制实现神经元兴奋性的稳态

• DOI: 10.1093/med/9780199322299.003.0004
• 发表时间: 2015
• 作者: Meier JC;Semtner M;Wolfart J
• 通讯作者: Wolfart J

A Network Model Reveals That the Experimentally Observed Switch of the Granule Cell Phenotype During Epilepsy Can Maintain the Pattern Separation Function of the Dentate Gyrus

网络模型揭示实验观察到的癫痫期间颗粒细胞表型的转换可以维持齿状回的模式分离功能

• DOI: 10.1007/978-3-319-99103-0_23
• 作者: Hanuschkin A;Yim MY;Wolfart J
• 通讯作者: Wolfart J