The molecular identity, function, and epilepsy-related plasticity of voltage- and calcium-dependent potassium channels in dentate gyrus granule cells of mice and humans.

我们将确定齿状回颗粒细胞电压和钙依赖性钾通道的分子特性、功能和与癫痫相关的可塑性。为此，我们将使用电生理和分子生物学技术。将采用癫痫手术过程中获得的人类海马区组织和癫痫动物模型。利用基于电导的计算机模拟，我们将精确地剖析已识别的钾通道在生理和病理生理条件下的功能影响。

We will determine the molecular identity, function, and epilepsy-related plasticity of voltage- and calcium-dependent potassium channels of dentate gyrus granule cells. To this end we will use electrophysiological and molecular biology techniques. Hippocampal tissue of humans obtained during epilepsy surgery and epilepsy animal models will be employed. Using conductance-based computer simulations, we will precisely dissect the functional impact of identified potassium channels under physiological and pathophysiological conditions.