Collaborative Research: IRES: Development of Novel Paper-Based Devices to Assess the Quality of Pharmaceuticals and Water in the Developing World

合作研究：IRES：开发新型纸质设备来评估发展中国家的药品和水质量

• 批准号: 1559497
• 负责人: Marya Lieberman
• 金额: $ 5.46万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1559497&HistoricalAwards=false
• 关键词: Collaborative; Research; IRES; Development; Novel

This IRES student training project will support research experiences in Nepal and Kenya by a total of 15 students (12 undergraduate and 3 graduate students) over three years. The students will develop, produce and evaluate paper-based devices used to test pharmaceutical quality and water quality. The primary goal of the project is to help students become more passionate about the power of science and engineering to solve global challenges while also developing valuable analysis and design skills. The project is led by principal investigator (PI) Dr. Toni Barstis of St. Mary's College, with co-PIs Dr. Reena Lamichhane Khadka and Dr. Donald Paetkau also of St. Mary's, and Dr. Marya Lieberman of the University of Notre Dame. The international mentors are Dr. Basant Giri of the Kathmandu Institute of Applied Sciences in Nepal, and Dr. Beatrice Jakait and Dr. Sonak Pastakia of the Academic Model Providing Access to Healthcare program (AMPATH) in Kenya. Estimates suggest that in developing countries such as Nepal and Kenya up to 30% of the medicines are falsified or substandard and up to 90% of the water sources may be contaminated with bacteria. However, most tests used in the U.S. to evaluate water or pharmaceutical purity are too complicated for use in developing countries, requiring steady power sources, ultrapure water or other expensive materials. The paper-based assays that this project will develop and evaluate are low-cost, require only small volumes of liquid, use readily available materials, and require no power source. The devices and this training have potential value anywhere a cheap, easy to use testing method is needed. Through this project U.S. students will have the opportunity to build competency as global scientists and engineers by developing collaborative relationships with students and research mentors in Nepal and Kenya, and seeing how their scientific knowledge can make a difference in communities. Applicants will be primarily chosen from St. Mary's College, an all-women liberal arts college, and from alumni of a Notre Dame REU that targeted students from primarily undergraduate institutions and included many women, first generation-to-attend-college students and underrepresented minorities, providing strong potential for this project to include a diverse range of student participants. Three cohorts of U.S. students will conduct research in the summers of 2017-2019 to develop paper-based, milli-fluidic analytical devices (PADs) to analyze pharmaceuticals and drinking water. Students will design and field-test the devices, comparing the outcomes from the PADs with "gold standard" analytical methods including High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). Students will work at sites in Nepal and Kenya, where previous international collaborations by the PIs have laid the groundwork for safe living and working conditions for the participants and where the students can make genuinely useful contributions to ongoing projects led by the Nepali and Kenyan mentors. U.S. students traveling to Nepal and Kenya will first work together at their home institutions designing and manufacturing PADs, while in electronic contact with their international mentors and the international students who will be part of the research teams. The U.S. students will then spend at least four weeks in their respective country collecting samples, conducting field and lab testing, engaging in cultural activities, and meeting with experts and community members impacted by the research. Students will also be in electronic contact with the other country group to compare data and experiences during the time abroad. The summer program will conclude at the home institutions with further analyses and data validation, presentation locally and with international students electronically, and report preparation for presentation to the appropriate country agencies. Users of the research results may include: WHO RapidAlert Network, the Nepali Department of Drug Administration, the Nepal Water Supply Corporation, UNICEF-Nepal, and the Kenyan Pharmacy and Poisons Board.

该IRES学生培训项目将在三年内支持15名学生(12名本科生和3名研究生)在尼泊尔和肯尼亚的研究经验。学生们将开发、生产和评估用于测试药品质量和水质的纸基设备。该项目的主要目标是帮助学生对科学和工程解决全球挑战的力量产生更大的热情，同时也培养有价值的分析和设计技能。该项目由圣玛丽学院的首席研究员Toni Barstis博士领导，联合研究员也是圣玛丽学院的Reena Lamichhane Khadka博士和Donald Paetkau博士，以及圣母大学的Marya Lieberman博士。国际导师是尼泊尔加德满都应用科学研究所的Basant Giri博士，以及肯尼亚学术模式提供医疗保健计划(AMPATH)的Beatrice Jakait博士和Sonak Pastaki博士。据估计，在尼泊尔和肯尼亚等发展中国家，多达30%的药品是伪造的或不合格的，多达90%的水源可能受到细菌污染。然而，美国用来评估水或药物纯度的大多数测试过于复杂，不适合在发展中国家使用，需要稳定的电源、超纯水或其他昂贵的材料。该项目将开发和评估的纸基分析成本低，只需要少量的液体，使用现成的材料，并且不需要电源。这些设备和这种培训在任何需要廉价、易于使用的测试方法的地方都具有潜在的价值。通过这个项目，美国学生将有机会通过与尼泊尔和肯尼亚的学生和研究导师发展合作关系，并看到他们的科学知识如何在社区中发挥作用，来建立作为全球科学家和工程师的能力。申请者将主要从圣玛丽学院和巴黎圣母院的校友中挑选，圣玛丽学院是一所全女性文理学院，该校的学生主要来自本科院校，其中包括许多女性、第一代在校大学生和代表不足的少数族裔，这为该项目提供了强大的潜力，包括不同的学生参与者。三批美国学生将在2017-2019年夏季进行研究，开发纸基微流控分析设备(PADS)来分析药品和饮用水。学生们将设计和现场测试这些设备，将PADS的结果与包括高效液相色谱(HPLC)和质谱仪(MS)在内的“黄金标准”分析方法进行比较。学生将在尼泊尔和肯尼亚的地点工作，在那里，国际和平机构之前的国际合作为参与者的安全生活和工作条件奠定了基础，学生们可以为尼泊尔和肯尼亚导师领导的正在进行的项目做出真正有用的贡献。前往尼泊尔和肯尼亚的美国学生首先将在本国机构一起设计和制造焊盘，同时与他们的国际导师和将成为研究团队成员的国际学生进行电子联系。然后，美国学生将在各自的国家花费至少四周的时间收集样本，进行实地和实验室测试，参与文化活动，并会见受研究影响的专家和社区成员。学生们还将与另一个国家组进行电子联系，以比较出国期间的数据和经验。暑期方案将在国内机构结束，进行进一步的分析和数据验证，在当地和与国际学生以电子方式介绍，并编写报告提交给适当的国家机构。研究结果的使用者可能包括：世卫组织快速警报网络、尼泊尔药物管理局、尼泊尔供水公司、联合国儿童基金会尼泊尔办事处和肯尼亚药房和毒药管理局。

项目成果

Discrimination of Substandard and Falsified Formulations from Genuine Pharmaceuticals Using NIR Spectra and Machine Learning

• DOI: 10.1021/acs.analchem.2c00998
• 发表时间: 2022-09-06
• 期刊: ANALYTICAL CHEMISTRY
• 影响因子: 7.4
• 作者: Awotunde, Olatunde;Roseboom, Nicholas;Lieberman, Marya
• 通讯作者: Lieberman, Marya