Approaches to Diverse Fluoroorganics and Fluorinated Building Blocks

多种含氟有机物和氟化砌块的制备方法

• 批准号: 1565754
• 负责人: Barbara Zajc
• 金额: $ 45万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1565754&HistoricalAwards=false
• 关键词: Approaches; Diverse; Fluoroorganics; Fluorinated; Building

The Chemical Synthesis Program of the NSF Chemistry Division supports the research of Professor Barbara Zajc in the Department of Chemistry at the City College of the City University of New York. Professor Zajc and her students develop novel methods for synthesis of fluorinated organic compounds. Organofluorine compounds are of importance in diverse fields, including agrochemicals and pharmaceuticals, materials sciences, and as biological probes. Approximately one in five pharmaceuticals contains a fluorine atom. Fluorine-18 (18F) labeled organofluorine compounds are often used in medicine (for positron emission tomography (PET) imaging). As an example, 2-deoxy-2-(18F)-D-glucose is commonly used in brain imaging. Organofluorine compounds are also rapidly gaining importance as Magnetic Resonance Imaging (MRI) contrast agents - also used in the diagnosis of disease. 19F MRI is being studied for brain imaging, for instance, visualizing amyloid plaque formation in Alzheimer's disease. Development of novel methods for the efficient synthesis of organofluorine compounds, which is the focus of this funded project, is therefore of strong interest. Students in Professor Zajc's research group are of diverse ethnicity and from an international community. Research projects are designed for training students at all educational levels, in order to provide experience in an area of societal relevance.The unique and valuable properties of organofluorine compounds make them important in a range of scientific areas. However, selective introduction of fluorine atoms into organic molecules continues to be challenging. This project develops novel chemical approaches to various classes of regiospecifically fluorinated compounds - those containing chiral centers. Some of the molecules developed may have a direct impact on studying neurodegenerative disorders. The approaches undertaken here focus on modular assemblies using new fluorinated building blocks. Where applicable, the role of fluorine on reactivity is studied. Due to the widespread importance of organofluorine compounds in medicinal and biological chemistry, including diagnostics such as the study of brain disorders using 19F MRI imaging, this research may have impact in areas beyond chemical synthesis. The research activities involve education and training of students from diverse ethnic groups, including those that are underrepresented in the sciences. The City College of New York has a large minority student population, and their education and training has an impact on a diversified workforce.

NSF化学部的化学合成计划支持纽约城市学院化学系的Barbara Zajc教授的研究。 Zajc教授和她的学生开发了合成氟化有机化合物的新方法。 有机氟化合物在许多领域都很重要，包括农用化学品和药物、材料科学以及作为生物探针。 大约五分之一的药物含有氟原子。氟-18（18F）标记的有机氟化合物通常用于医学（用于正电子发射断层扫描（PET）成像）。 例如，2-脱氧-2-（18 F）-D-葡萄糖通常用于脑成像。 有机氟化合物作为磁共振成像（MRI）造影剂的重要性也在迅速增加-也用于疾病诊断。 19 F MRI正在研究用于脑成像，例如，可视化阿尔茨海默病中的淀粉样斑块形成。 因此，开发有效合成有机氟化合物的新方法，这是该资助项目的重点，具有浓厚的兴趣。 Zajc教授研究小组的学生来自不同的种族和国际社会。 研究项目旨在培训各级教育水平的学生，以便提供具有社会意义的领域的经验。有机氟化合物的独特和宝贵性质使其在一系列科学领域中发挥重要作用。 然而，将氟原子选择性地引入有机分子中仍然具有挑战性。 该项目开发了新的化学方法，以各种类别的区域特异性氟化化合物-那些含有手性中心。 开发的一些分子可能对研究神经退行性疾病产生直接影响。 这里采用的方法集中在使用新的氟化结构单元的模块化组件上。 在适用的情况下，氟对反应性的作用进行了研究。 由于有机氟化合物在医药和生物化学中的广泛重要性，包括使用19 F MRI成像研究脑部疾病等诊断，这项研究可能会对化学合成以外的领域产生影响。 研究活动涉及教育和培训来自不同族裔群体的学生，包括那些在科学领域代表性不足的学生。 纽约城市学院有大量的少数族裔学生，他们的教育和培训对多样化的劳动力产生了影响。