Chemical Methodologies to Regiospecifically Fluorinated Organic Compounds

通过这个项目，化学合成计划正在资助纽约城市学院化学系的Barbara Zajc教授，以进一步开发在不同分子环境中特定区域安装氟乙烯功能的方法。 这些研究是生物有机化学和药物化学领域的基本兴趣，由于氟化官能团的价值，特别是在提高代谢稳定性和允许分子跟踪和成像，分别通过NMR和PET技术。要采取的方法包括探索新的氟化Julia-Kocienski试剂，包括双向方法，以及那些携带常驻手性中心的试剂。 Shapiro反应的改进也在开发中，作为对氟乙烯的补充。由于有机氟化合物在制药和农用化学品、结构活性研究中的NMR探针以及PET成像剂等方面有着广泛的应用，因此这项研究有望产生更广泛的科学影响。 更广泛的影响还包括在纽约市立大学的一个研究小组中培训多样化的学生群体，其中包括本科生和研究生以及博士后研究人员。 Zajc将继续她的外展活动，以当地高中和计划以外的城市学院，旨在为学生提供动手实验室的经验。

With this project, the Chemical Synthesis Program is funding Professor Barbara Zajc of the Department of Chemistry at City College of The City University of New York to further develop methodology toward the regiospecific installation of vinylic fluoride functionality in diverse molecular settings. Such studies are of fundamental interest to the fields of bioorganic and medicinal chemistry, owing to the value of fluorinated functionality, particularly in enhancing metabolic stability and permitting molecular tracing and imaging, by NMR and PET-techniques, respectively. The approaches to be taken include the exploration of new fluorinated Julia-Kocienski reagents, including bidirectional approaches, and those carrying resident chiral centers. A modification of the Shapiro reaction is also under development as a complementary entry into vinyl fluorides.Since organofluorine compounds have seen broad applications, from pharmaceuticals and agrochemicals, to NMR probes in structure-activity studies, to PET-imaging agents, this research is expected to have a wider scientific impact. The broader impacts also involve training of a diverse student population, in a research group setting at CUNY that includes undergraduate and graduate students, as well as postdoctoral researchers. Prof. Zajc will continue her outreach activities to local high schools and programs outside The City College that aim to provide students with hands on laboratory experience.