Chemical Methodologies to Regiospecifically Fluorinated Organic Compounds

区域特异性氟化有机化合物的化学方法

• 批准号: 1058618
• 负责人: Barbara Zajc
• 金额: $ 24万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1058618&HistoricalAwards=false
• 关键词: Chemical; Methodologies; Regiospecifically; Fluorinated; Organic

With this project, the Chemical Synthesis Program is funding Professor Barbara Zajc of the Department of Chemistry at City College of The City University of New York to further develop methodology toward the regiospecific installation of vinylic fluoride functionality in diverse molecular settings. Such studies are of fundamental interest to the fields of bioorganic and medicinal chemistry, owing to the value of fluorinated functionality, particularly in enhancing metabolic stability and permitting molecular tracing and imaging, by NMR and PET-techniques, respectively. The approaches to be taken include the exploration of new fluorinated Julia-Kocienski reagents, including bidirectional approaches, and those carrying resident chiral centers. A modification of the Shapiro reaction is also under development as a complementary entry into vinyl fluorides.Since organofluorine compounds have seen broad applications, from pharmaceuticals and agrochemicals, to NMR probes in structure-activity studies, to PET-imaging agents, this research is expected to have a wider scientific impact. The broader impacts also involve training of a diverse student population, in a research group setting at CUNY that includes undergraduate and graduate students, as well as postdoctoral researchers. Prof. Zajc will continue her outreach activities to local high schools and programs outside The City College that aim to provide students with hands on laboratory experience.

通过这个项目，化学合成项目资助了纽约城市大学城市学院化学系的Barbara Zajc教授，以进一步开发在不同分子环境中特定区域安装氟乙烯功能的方法。由于氟化功能的价值，特别是在增强代谢稳定性和允许分别通过核磁共振和pet技术进行分子追踪和成像方面的价值，这些研究对生物有机化学和药物化学领域具有根本意义。要采取的方法包括探索新的氟化Julia-Kocienski试剂，包括双向方法和携带驻留手性中心的方法。对夏皮罗反应的一种改进也在开发中，作为氟乙烯的补充入口。由于有机氟化合物有广泛的应用，从制药和农用化学品，到结构活性研究中的核磁共振探针，再到pet显像剂，预计这项研究将产生更广泛的科学影响。更广泛的影响还包括培养多样化的学生群体，在纽约市立大学的一个研究小组环境中，包括本科生和研究生，以及博士后研究人员。扎伊克教授将继续在当地高中和城市学院以外的项目开展推广活动，旨在为学生提供动手实验经验。