DISSERTATION RESEARCH: Harnessing genomics to test the mechanisms causing adaptive phenotypic divergence along elevational gradients in a poison frog.
论文研究:利用基因组学来测试导致毒蛙沿海拔梯度适应性表型发散的机制。
基本信息
- 批准号:1601780
- 负责人:
- 金额:$ 1.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-06-01 至 2018-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project investigates how environmental conditions along mountainsides leads to genetic change and divergence among different frog populations. Identifying the mechanisms by which populations genetically diverge, and eventually become separate species, is important for understanding the origins of biological diversity. Ecological differences along environmental gradients can drive divergence among populations. This project will identify the genes responsible for genetic divergence of trait values among populations of Anthony?s poison arrow frog, Epipedobates anthonyi, which occurs along multiple mountainsides and elevation gradients in Ecuador. The researchers will test for natural selection on genes and relate that selection to environmental factors so as to determine which are responsible for the observed divergence. The results will contribute to our understanding of why tropical systems are so diverse and help predict evolutionary responses to climate change. In addition, the project includes the training of undergraduates, educational workshops, and K-12 outreach activities. This project takes advantage of a unique study system to investigate the drivers and mechanisms that promote population divergence in the absence of geographic isolation. Populations of Epipedobates anthonyi show phenotypic divergence along elevation gradients in putatively adaptive traits including size, coloration, male advertisement calls, and thermal tolerance. Despite this phenotypic divergence, analyses of neutral genetic variation indicate that these populations are not isolated. Using genomic approaches, the researchers will examine signatures of divergent selection across the genome, correlate environmental variation with the observed divergence, and detect genetic changes likely responsible for observed phenotypic variation across elevation gradients. Tissue samples have been collected from 35 populations that encompass the distribution of this species across four replicated elevational gradients. This highly integrative project will provide an in-depth analysis of the relative roles of adaptive genetic differentiation and phenotypic plasticity on observed patterns of phenotypic divergence in natural populations.
这个项目调查了沿着山坡的环境条件如何导致不同青蛙种群之间的遗传变化和分歧。确定种群遗传分化并最终成为独立物种的机制对于理解生物多样性的起源非常重要。沿着环境梯度的生态差异可以驱动种群之间的分化。该项目将确定基因负责遗传分歧的性状值之间的人口安东尼?一种分布于厄瓜多尔沿着多个山坡和海拔梯度的箭毒蛙Epipedobates anthonyi。研究人员将测试基因的自然选择,并将这种选择与环境因素联系起来,以确定哪些因素对观察到的分歧负责。这些结果将有助于我们理解为什么热带系统如此多样化,并有助于预测对气候变化的进化反应。此外,该项目还包括本科生培训、教育讲习班和K-12外联活动。该项目利用一个独特的研究系统来调查在没有地理隔离的情况下促进种群分化的驱动因素和机制。花上足螨种群在体型、体色、雄虫广告叫声和耐热性等蛹适应性状上沿海拔梯度表现出沿着的表型差异。尽管这种表型的分歧,中性遗传变异的分析表明,这些人口并不是孤立的。使用基因组方法,研究人员将检查整个基因组的分歧选择的签名,将环境变化与观察到的分歧相关联,并检测可能导致观察到的海拔梯度表型变异的遗传变化。组织样本已收集到35个种群,包括分布在四个重复的海拔梯度的这个物种。这个高度综合性的项目将提供一个深入的分析的相对作用的适应性遗传分化和表型可塑性观察到的模式在自然种群的表型分歧。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Chris Funk其他文献
Too simple, too complex, or just right? Advantages, challenges and resolutions for indicators of genetic diversity
太简单、太复杂还是恰到好处?
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
●. Belma;Kalamujić Stroil;L. Laikre;Alicia Mastretta;Katie Millette;Ivan Paz‐Vinas;Lucia Ruiz Bustos;Robyn E. Shaw;Cristiano Vernesi;Chris Funk;C. Grueber;Francine Kershaw;Anna J. MacDonald;Mariah H. Meek;Cinnamon S. Mittan;David O'Brien;Rob Ogden;G. Segelbacher - 通讯作者:
G. Segelbacher
High resolution climate change observations and projections for the evaluation of heat-related extremes
用于评估与热相关极端事件的高分辨率气候变化观测和预测
- DOI:
10.1038/s41597-024-03074-w - 发表时间:
2024-03-01 - 期刊:
- 影响因子:6.900
- 作者:
Emily Williams;Chris Funk;Pete Peterson;Cascade Tuholske - 通讯作者:
Cascade Tuholske
Does humidity matter? Prenatal heat and child health in South Asia
湿度重要吗?
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Kathryn McMahon;Kathy Baylis;Stuart Sweeney;Chris Funk - 通讯作者:
Chris Funk
Warming accelerates global drought severity
气候变暖加剧了全球干旱的严重性
- DOI:
10.1038/s41586-025-09047-2 - 发表时间:
2025-06-04 - 期刊:
- 影响因子:48.500
- 作者:
Solomon H. Gebrechorkos;Justin Sheffield;Sergio M. Vicente-Serrano;Chris Funk;Diego G. Miralles;Jian Peng;Ellen Dyer;Joshua Talib;Hylke E. Beck;Michael B. Singer;Simon J. Dadson - 通讯作者:
Simon J. Dadson
SSEBop Evapotranspiration Estimates Using Synthetically Derived Landsat Data from the Continuous Change Detection and Classification Algorithm
使用连续变化检测和分类算法合成的陆地卫星数据进行 SSEBop 蒸散量估算
- DOI:
10.3390/rs16071297 - 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Mikael P. Hiestand;H. Tollerud;Chris Funk;G. Senay;Kate C. Fickas;M. Friedrichs - 通讯作者:
M. Friedrichs
Chris Funk的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Chris Funk', 18)}}的其他基金
Collaborative Research: RAPID: Testing the Mechanisms and Consequences of an Adaptive Response to a Catastrophic Fire and Heatwave in Stream Frogs
合作研究:RAPID:测试溪流青蛙对灾难性火灾和热浪的适应性响应的机制和后果
- 批准号:
2221809 - 财政年份:2022
- 资助金额:
$ 1.96万 - 项目类别:
Standard Grant
RoL: FELS: EAGER: Landscape Phenomics: Predicting vulnerability to climate variation by linking environmental heterogeneity to genetic and phenotypic variation
RoL:FELS:EAGER:景观表型组学:通过将环境异质性与遗传和表型变异联系起来预测气候变化的脆弱性
- 批准号:
1838282 - 财政年份:2018
- 资助金额:
$ 1.96万 - 项目类别:
Standard Grant
Collaborative Research: Testing Mechanisms of Microgeographic Adaptation
合作研究:微观地理适应的测试机制
- 批准号:
1754821 - 财政年份:2018
- 资助金额:
$ 1.96万 - 项目类别:
Standard Grant
DISSERTATION RESEARCH: Temporal Sampling and DNA Metabarcoding to Test the Climate Variability Hypothesis
论文研究:时间采样和 DNA 元条形码来检验气候变异假说
- 批准号:
1502008 - 财政年份:2015
- 资助金额:
$ 1.96万 - 项目类别:
Standard Grant
How Does Gene Flow Affect Local Adaptation and Population Dynamics?: Experimental Tests in Wild Populations and Mesocosms
基因流如何影响局部适应和种群动态?:野生种群和中生态系统的实验测试
- 批准号:
1146489 - 财政年份:2012
- 资助金额:
$ 1.96万 - 项目类别:
Standard Grant
相似国自然基金
Research on Quantum Field Theory without a Lagrangian Description
- 批准号:24ZR1403900
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
Cell Research
- 批准号:31224802
- 批准年份:2012
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research
- 批准号:31024804
- 批准年份:2010
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research (细胞研究)
- 批准号:30824808
- 批准年份:2008
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Research on the Rapid Growth Mechanism of KDP Crystal
- 批准号:10774081
- 批准年份:2007
- 资助金额:45.0 万元
- 项目类别:面上项目
相似海外基金
CLIMA/Collaborative Research: Enhancing Soil-Based Infrastructure Resilience to Climate Change: Harnessing the Potential of Fractured Soil by Adding Biopolymers
CLIMA/合作研究:增强土壤基础设施对气候变化的抵御能力:通过添加生物聚合物来利用破碎土壤的潜力
- 批准号:
2332082 - 财政年份:2024
- 资助金额:
$ 1.96万 - 项目类别:
Continuing Grant
CLIMA/Collaborative Research: Enhancing Soil-Based Infrastructure Resilience to Climate Change: Harnessing the Potential of Fractured Soil by Adding Biopolymers
CLIMA/合作研究:增强土壤基础设施对气候变化的抵御能力:通过添加生物聚合物来利用破碎土壤的潜力
- 批准号:
2332081 - 财政年份:2024
- 资助金额:
$ 1.96万 - 项目类别:
Continuing Grant
Collaborative Research: CSR: Medium: Fortuna: Characterizing and Harnessing Performance Variability in Accelerator-rich Clusters
合作研究:CSR:Medium:Fortuna:表征和利用富含加速器的集群中的性能变异性
- 批准号:
2312689 - 财政年份:2023
- 资助金额:
$ 1.96万 - 项目类别:
Continuing Grant
Collaborative Research: DMREF: Developing and Harnessing the Platform of Quasi-One-Dimensional Topological Materials for Novel Functionalities and Devices
合作研究:DMREF:开发和利用用于新功能和器件的准一维拓扑材料平台
- 批准号:
2324033 - 财政年份:2023
- 资助金额:
$ 1.96万 - 项目类别:
Standard Grant
Collaborative Research: Education DCL: EAGER: Harnessing the Power of Large Language Models in Digital Forensics Education at MSI and HBCU
合作研究:教育 DCL:EAGER:在 MSI 和 HBCU 的数字取证教育中利用大型语言模型的力量
- 批准号:
2333951 - 财政年份:2023
- 资助金额:
$ 1.96万 - 项目类别:
Standard Grant
Collaborative Research: CSR: Medium: Fortuna: Characterizing and Harnessing Performance Variability in Accelerator-rich Clusters
合作研究:CSR:Medium:Fortuna:表征和利用富含加速器的集群中的性能变异性
- 批准号:
2401244 - 财政年份:2023
- 资助金额:
$ 1.96万 - 项目类别:
Continuing Grant
Collaborative Research: Harnessing the chirality matching principle for enhanced catalytic reactivity
合作研究:利用手性匹配原理增强催化反应活性
- 批准号:
2247709 - 财政年份:2023
- 资助金额:
$ 1.96万 - 项目类别:
Continuing Grant
Excellence in Research: Harnessing Big Data and Domain Knowledge to Advance Deep Learning for Interpretable Cell Quantitation
卓越的研究:利用大数据和领域知识推进深度学习以实现可解释的细胞定量
- 批准号:
2302274 - 财政年份:2023
- 资助金额:
$ 1.96万 - 项目类别:
Standard Grant
NCI Clinical Trial Research Strategy, Harnessing of Equity, and Implementation
NCI 临床试验研究策略、公平利用和实施
- 批准号:
10721134 - 财政年份:2023
- 资助金额:
$ 1.96万 - 项目类别:
Harnessing the potential of implementation science to define research priorities that advance Universal Health Coverage (UHC): A Research Agenda-Setting Workshop Aligned to a Multi-Country Delphi Study
利用实施科学的潜力来确定推进全民健康覆盖 (UHC) 的研究重点:与多国德尔菲研究相一致的研究议程设置研讨会
- 批准号:
480864 - 财政年份:2023
- 资助金额:
$ 1.96万 - 项目类别:
Miscellaneous Programs