NSF Postdoctoral Fellowship in Biology FY 2016

2016 财年 NSF 生物学博士后奖学金

基本信息

  • 批准号:
    1612261
  • 负责人:
  • 金额:
    $ 13.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Fellowship Award
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-01 至 2018-08-31
  • 项目状态:
    已结题

项目摘要

Postdoctoral Fellow: Tayloria AdamsProposal Number: 1612261This action funds an NSF Postdoctoral Research Fellowship in Biology for FY 2016, Broadening Participation of Groups Under-represented in Biology. The fellowship supports a research and training plan for the Fellow to develop novel cell-based biosensors and increase the participation of groups underrepresented in biology. The title of the research plan for this fellowship to Tayloria N.G. Adams is "Novel separation of neural lineage cells to determine progenitor cell characteristics." The host institution for this fellowship is the University of California-Irvine and the sponsoring scientist is Dr. Lisa Flanagan.The goal of this project is to sort and characterize neural stem progenitor cells with a multiple frequency dielectrophoresis (DEP) system, which employs electric fields to induce cell motion based on intrinsic cell properties. More specifically, the Fellow is creating a DEP microdevice to isolate distinct progenitor cells based on their differences in membrane capacitance and using biological assays to determine the critical cell molecules contributing to membrane capacitance. In the central nervous system, neural stem cells form specialized neurons, astrocytes, and oligodendrocytes that work together to form neural networks that transmit information. A challenge with neural stem cells is that little is known about their transition from stem cells to distinct progenitor cells on their way to forming final specialized cells. Dielectrophoresis, a technology that relies on electric fields to study cells, offers a solution by providing information about cell's membrane capacitance, which can be used to identify progenitors that will form astrocytes and neurons. However, the molecular components that contribute to membrane capacitance are not well studied. The Fellow's research is enabling the characterization of cell surface molecules that regulate whether a neural stem cell becomes an astrocyte versus a neuron. The Fellow's research fills a scientific gap by explaining membrane capacitance in terms of biological function/characteristics, thereby bridging two disparate fields - cell biology and chemical engineering. Ultimately, the Fellow's studies are helping to uncover important differences in these cells and shed light on the processes that control cell generation during brain and spinal cord formation.The Fellow is being trained in an interdisciplinary capacity, merging biology and engineering, and is broadening participation of underrepresented groups by increasing minorities in STEM. The Fellow's training includes responsible conduct of research training, career counseling, and professional networking. The Fellow, recognizing the importance of support programs for minority students in academia, is working with an afterschool program, Girls Inc., to broaden participation. As part of this effort, the Fellow is providing girls in grades 5-12 with a biological sciences curriculum designed to explore organ structure and function. The Fellow's contributions include curriculum development, co-teaching, and implementing scholarship/internship application components to introduce students to STEM opportunities. For the girls in this program, the Fellow is reinforcing a positive learning environment, building confidence, and establishing a sense of belonging in science and engineering.
博士后研究员:Tayloria Adams提案编号:1612261这一行动资金NSF博士后研究奖学金在生物学为2016财年,扩大在生物学代表性不足的群体的参与。该研究金支持研究员的研究和培训计划,以开发新型细胞生物传感器,并增加生物学中代表性不足的群体的参与。该奖学金的研究计划的标题为Tayloria N.G.亚当斯是“新的分离神经谱系细胞,以确定祖细胞的特点。“该奖学金的主办机构是加州大学欧文分校,赞助科学家是丽莎弗拉纳根博士。该项目的目标是利用多频介电电泳(DEP)系统对神经干祖细胞进行分类和表征,该系统利用电场诱导细胞基于内在细胞特性的运动。更具体地说,该研究员正在创建一个DEP微型设备,以根据其膜电容的差异分离不同的祖细胞,并使用生物测定来确定有助于膜电容的关键细胞分子。在中枢神经系统中,神经干细胞形成特化的神经元、星形胶质细胞和少突胶质细胞,它们一起工作以形成传递信息的神经网络。神经干细胞面临的一个挑战是,人们对它们在形成最终特化细胞的过程中从干细胞向不同祖细胞的转变知之甚少。介电电泳是一种依靠电场来研究细胞的技术,它通过提供有关细胞膜电容的信息来提供解决方案,这些信息可用于识别将形成星形胶质细胞和神经元的祖细胞。然而,有助于膜电容的分子组分没有得到很好的研究。该研究员的研究使细胞表面分子的特性,调节是否神经干细胞成为星形胶质细胞与神经元。该研究员的研究填补了科学空白,解释了生物功能/特性方面的膜电容,从而弥合了两个不同的领域-细胞生物学和化学工程。最终,研究员的研究有助于揭示这些细胞的重要差异,并阐明在大脑和脊髓形成过程中控制细胞生成的过程。研究员正在接受跨学科能力的培训,将生物学和工程学融合在一起,并通过增加STEM中的少数群体来扩大代表性不足的群体的参与。研究员的培训包括负责任地进行研究培训,职业咨询和专业网络。该研究员认识到支持少数民族学生在学术界的重要性,正在与课后计划,女孩公司,扩大参与。作为这项努力的一部分,该研究员正在为5-12年级的女孩提供生物科学课程,旨在探索器官结构和功能。研究员的贡献包括课程开发,共同教学,并实施奖学金/实习申请组件,向学生介绍STEM机会。对于这个项目的女孩,研究员正在加强积极的学习环境,建立信心,并建立科学和工程的归属感。

项目成果

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会议论文数量(0)
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Tayloria Adams其他文献

Tayloria Adams的其他文献

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{{ truncateString('Tayloria Adams', 18)}}的其他基金

CAREER: Engineering MSC Progenitors using Dielectrophoresis for Better Cell Therapies
职业:使用介电泳工程 MSC 祖细胞以获得更好的细胞疗法
  • 批准号:
    2048221
  • 财政年份:
    2021
  • 资助金额:
    $ 13.8万
  • 项目类别:
    Continuing Grant

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