权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Doctoral Dissertation Research: Affiliative Social Relationships and Immune Function in Primates

博士论文研究：灵长类动物的附属社会关系和免疫功能

基本信息

批准号：
1613393
负责人：
Cheryl Knott
金额：
$ 2.51万
依托单位：
Trustees of Boston University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-15 至 2019-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1613393&HistoricalAwards=false
关键词：
Doctoral Dissertation Research Affiliative Social

项目摘要

Most primates are social species, and sociality comes with both benefits and costs. This doctoral dissertation project will assess underlying mechanisms by which social bonds shape well-being in primates. The investigator will study the interaction of behavior, hormones, immune function, and pathogens, to see whether stronger social bonds are associated with better immune function and lower physiological stress. The findings from this study will provide a comparative model for understanding sociality in our own species. The project will also further science education outreach and student training, primate conservation efforts, and development of international collaborations.This project will investigate social buffering in wild chimpanzees at Ngogo, Kibale National Park, Uganda - the largest wild chimpanzee community ever studied. To assess the physiological and immunological correlates of social bonds, the investigators will measure dyadic bond strength, glucocorticoids (which reflect physiological reactions to stress and, when chronically elevated, impair immune function), oxytocin (a nonapeptide correlated with social bonding that may also attenuate glucocorticoid secretion), markers of immune activation (i.e., urinary neopterin and body temperature), and the presence of pathogenic infection. The investigators will noninvasively collect behavioral observations, urine, and feces from 50 adult and adolescent chimpanzees. Hormones and immune biomarkers will then be analyzed and infectious agents will be sequenced.

大多数灵长类动物都是群居动物，群居既有好处，也有代价。这个博士论文项目将评估社会纽带在灵长类动物中塑造幸福的潜在机制。研究者将研究行为、激素、免疫功能和病原体之间的相互作用，以了解更强的社会关系是否与更好的免疫功能和更低的生理压力有关。这项研究的发现将为理解我们自己物种的社会性提供一个比较模型。该项目还将促进科学教育推广和学生培训、灵长类动物保护工作以及国际合作的发展。这个项目将调查乌干达Kibale国家公园Ngogo的野生黑猩猩的社会缓冲，这是迄今为止研究过的最大的野生黑猩猩群落。为了评估社会联系的生理和免疫学相关性，研究人员将测量双元结合强度、糖皮质激素（反映对压力的生理反应，当长期升高时，会损害免疫功能）、催产素（一种与社会联系相关的非肽，也可能减弱糖皮质激素的分泌）、免疫激活标志物（即尿新蝶呤和体温）和致病性感染的存在。研究人员将收集50只成年和青少年黑猩猩的行为观察、尿液和粪便。然后将分析激素和免疫生物标志物，并对感染因子进行测序。