Doctoral Dissertation Research: The effect of lifetime investment in reproduction and physical activity on women's rates of senescence

博士论文研究：生殖和体力活动的终生投资对女性衰老率的影响

• 批准号: 1613433
• 负责人: Catherine Panter-Brick
• 金额: $ 2.52万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-15 至 2018-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1613433&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Research; effect; lifetime

What drives variation in how fast women will age? This doctoral dissertation project is a comparative study of rural and urban women to investigate whether lifetime reproductive behaviors and physical activity patterns have long-lasting impact on biological aging. The investigators will examine the physiological mechanisms associated with reproductive and physical behaviors that energetically tax women's bodies across their lives. Findings from the project will contribute to our understanding of aging at the cellular level and in the context of human life history. The project will promote international collaboration, support the acquisition of new research skills for students participating in fieldwork and lab activities, and produce data that may inform clinical and policy research on women's health and aging. This study examines whether physiological tradeoffs impact rates of senescence in contexts where women have to allocate limited resources to competing energetic demands across the life course. It uses a comparative design with two populations - rural and urban women - who vary in lifetime reproductive investments and contrast in their physical activity levels. The researchers predict that women's levels of lifetime reproductive investment will be directly associated with their levels of oxidative stress, a marker of cellular damage resulting from aerobic metabolism and a potential indicator of physiological aging. They further predict that rural women, who assume vigorous physical activity over their lifetime, will demonstrate greater rates of physiological senescence relative to urban women - over and above the aging effects of reproduction. This research will be among the first of its kind to test the association between investments over the life course and variation in rates of biological aging while evaluating a mechanistic explanation for variation in rates of senescence over the lifespan.

是什么导致了女性衰老速度的变化？ 本博士论文项目是对农村和城市妇女的比较研究，以调查一生的生殖行为和身体活动模式是否对生物衰老产生长期影响。研究人员将研究与生殖和身体行为相关的生理机制，这些行为在女性的一生中对她们的身体产生了巨大的影响。该项目的发现将有助于我们在细胞水平和人类生活史的背景下理解衰老。该项目将促进国际合作，支持参与实地考察和实验室活动的学生获得新的研究技能，并产生可能为妇女健康和老龄化的临床和政策研究提供信息的数据。 这项研究探讨了生理权衡是否影响衰老率的情况下，妇女必须分配有限的资源，以竞争充满活力的需求在整个生命过程中。 它使用了两个人群（农村和城市女性）的比较设计，这两个人群在一生的生殖投资和身体活动水平上存在差异。研究人员预测，女性一生的生殖投资水平将与其氧化应激水平直接相关，氧化应激是有氧代谢引起的细胞损伤的标志，也是生理衰老的潜在指标。他们进一步预测，在一生中进行剧烈体育活动的农村妇女，相对于城市妇女，将表现出更大的生理衰老率-超过生育的衰老效应。这项研究将是同类研究中第一个测试生命过程中的投资与生物衰老速率变化之间的关联，同时评估对生命周期中衰老速率变化的机械解释。