SBIR Phase I: A Dual Wrist Patch Based System for Continuous Blood Pressure Monitoring.

SBIR 第一阶段：基于双腕贴片的连续血压监测系统。

• 批准号: 1621937
• 负责人: Les Bogdanowicz
• 金额: $ 22.5万
• 依托单位: Bold Diagnostics, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1621937&HistoricalAwards=false
• 关键词: SBIR; Phase; Dual; Wrist; Patch

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the ability to redefine how blood pressure is monitored and managed. The current standard of care for blood pressure measurement is to utilize discrete snapshots taken by cuff-based systems to manage a constantly changing pressure. These snapshots are often inaccurate and lead to uncontrolled blood pressure, a 45 billion dollar problem for our healthcare system. The proposed project will develop a non-invasive approach to continuously measure blood pressure. Accurate granular blood pressure trends would allow physicians to better manage high blood pressure, a major risk factor for cardiovascular disease, which affects over 100 million Americans today. Real-time blood pressure monitoring would also help patients understand the impact of their daily behaviors on blood pressure and promote healthy lifestyle choices. A continuous non-invasive blood pressure monitor has multiple market applications and would pioneer the field of continuous blood pressure analytics. The proposed project aims to develop a wrist based patch system that utilizes optical sensors to obtain pulse waveform data and a novel approach to convert it to blood pressure. The team will be developing a working prototype that acquires the raw data and converts it to absolute blood pressure. The prototype will also have the ability to transmit these blood pressures to a smart device for review. With successful development of the working prototype the team will then generate a databank to refine the algorithm used to convert differential pulse arrival time to blood pressure. Accurate outpatient blood pressure trends would take the guesswork out of blood pressure management and has the potential of identifying new prognostic markers for cardiovascular disease.

这个小型企业创新研究（SBIR）第一阶段项目的更广泛的影响/商业潜力是重新定义血压监测和管理方式的能力。目前的血压测量护理标准是利用基于袖带的系统拍摄的离散快照来管理不断变化的压力。这些快照通常是不准确的，并导致不受控制的血压，我们的医疗保健系统的450亿美元的问题。拟议的项目将开发一种非侵入性的方法来连续测量血压。准确的颗粒血压趋势将使医生能够更好地管理高血压，这是心血管疾病的主要风险因素，目前影响着1亿多美国人。实时血压监测还可以帮助患者了解日常行为对血压的影响，并促进健康的生活方式选择。连续无创血压监测仪具有多种市场应用，并将成为连续血压分析领域的先驱。该项目旨在开发一种基于手腕的贴片系统，该系统利用光学传感器获取脉搏波形数据，并采用一种新的方法将其转换为血压。该团队将开发一个工作原型，获取原始数据并将其转换为绝对血压。该原型还能够将这些血压传输到智能设备进行审查。随着工作原型的成功开发，该团队将生成一个数据库，以改进用于将差分脉冲到达时间转换为血压的算法。准确的门诊血压趋势将消除血压管理中的猜测，并有可能确定新的心血管疾病预后标志物。