Molecular characterization of stem cell differentiation and oocyte maturation using synchrotron infrared spectroscopy and Atomic Force Microscopy/Raman imaging

使用同步加速器红外光谱和原子力显微镜/拉曼成像对干细胞分化和卵母细胞成熟进行分子表征

• 批准号: DP0878464
• 负责人: Prof Bayden Wood
• 金额: $ 43.92万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0878464
• 关键词: Molecular; characterization; stem; cell; differentiation

There are currently no molecular based methods to assess oocyte maturation and stem cell differentiation at the single cell level. Consequently the need for such techniques is critical in placing Australia at the forefront in this rapidly expanding field. Such technology would give Australia a leading edge in stem cell and oocyte research and ultimately assist in discovering disease cures for debilitating neurodegenerative diseases and spinal chord injury, while techniques for determining the viability of oocytes may have important implications for future in vitro fertilization programs. The intellectual property and technologies developed from this research could also have potential to impact on the global market.

目前还没有基于分子的方法来评估单细胞水平的卵母细胞成熟和干细胞分化。因此，对这种技术的需求是至关重要的，使澳大利亚在这个迅速扩大的领域的前沿。这种技术将使澳大利亚在干细胞和卵母细胞研究方面处于领先地位，并最终有助于发现使人衰弱的神经退行性疾病和脊髓损伤的疾病治疗方法，而确定卵母细胞活力的技术可能对未来的体外受精计划产生重要影响。这项研究开发的知识产权和技术也有可能对全球市场产生影响。