Raman and synchrotron spectroscopy of nano-scale drug interactions and molecular processes in single living cells

单个活细胞中纳米级药物相互作用和分子过程的拉曼和同步加速器光谱

• 批准号: DP0664012
• 负责人: Prof Bayden Wood
• 金额: $ 20.08万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-03 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0664012
• 关键词: Raman; synchrotron; spectroscopy; nano; scale

The need for potent low-cost drugs is ever increasing, yet effective ways to screen for new drugs remain elusive. A spectroscopic approach to screening drugs in living cells would seem a logical alternative to chemically based and morphological methods that are the status quo. In this context we are developing methodology to analyse molecular target sites in single living cells for two of the most devastating diseases to afflict human kind, namely malaria and cancer. New ways of rapidly screening drugs in living cells prior to clinical trials will save an enormous amount of time, money and ultimately lives.

对强效低成本药物的需求正在不断增加，但筛选新药的有效方法仍然难以捉摸。在活细胞中筛选药物的光谱学方法似乎是现有的基于化学和形态学方法的合乎逻辑的替代方法。在这方面，我们正在发展一种方法，分析单个活细胞中的两种最具破坏性的疾病，即疟疾和癌症的分子靶位。在临床试验之前在活细胞中快速筛选药物的新方法将节省大量的时间和金钱，并最终挽救生命。