Doctoral Dissertation Research: Cultural-Biological Research on Stress and Gestational Age

博士论文研究：压力和胎龄的文化生物学研究

• 批准号: 1628643
• 负责人: Melissa Cheyney
• 金额: $ 2.14万
• 依托单位: Oregon State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-15 至 2018-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1628643&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Research; Cultural; Biological

The research supported by this award will investigate the relationship between culture and biology through the lens of maternal stress and pregnancy outcomes, particularly pre-terms births. Previous research has shown that some of the variability in rates of premature birth and thus the health of newborn babies can be attributed to social and cultural factors. However, little is known about the mechanisms that connect poverty, racism, and other social determinants with gestational age at delivery. Oregon State University anthropology doctoral student, Holly Horan, with the supervision of Dr. Melissa Cheyney, will investigate the possibility that maternal stress may be one linking factor. This is an important problem because globally, an estimated 15 million infants are born preterm each year. Preterm delivery, defined as a live-birth before 37 weeks gestational age, is a leading cause of death among children under five years of age, and is associated with lifelong, chronic health issues for those children who survive delivery. The research will be carried out in Puerto Rico which has the highest rate of preterm birth in the entire U.S. jurisdiction. Furthermore, the most common epidemiological variables linked to preterm birth (such as maternal age, smoking, maternal education, first trimester pre-natal care, and lacking health insurance) in other places do not account for the rate in Puerto Rico. Recently, however, researchers have suggested a new avenue of inquiry: a possible relationship between maternal stress and early delivery, although to date, findings from these studies have been equivocal due to methodological constraints. Therefore, Horan will refine stress research methods in order to more reliably characterize and examine relationships between cultural and biological factors. She will collect data with a mix of social and biological methods, including: participant observation; administering the Puerto Rican version of the Cohen Perceived Stress Scale (PSS) and the Revised Prenatal Distress Questionnaire (RPDQ); hair cortisol concentration (HCC) sampling; and semi-structured postpartum exit interviews. She will identify cultural models of maternal stress using exploratory, semi-structured interviews with an initial 25 participants. The PSS, RPDQ, and HCCs will be assessed at three points during gestation (10 to 12 weeks, 22 to 24 weeks, and 34 to 36 weeks) in an additional 100 women in order to identify trends in stress experiences and hormones by trimester. An exit interview will be conducted between four to eight weeks postpartum and a fourth and final hair cortisol sample will be collected from these 100 participants. Hair cortisol concentrations (HCCs) will be used to investigate the utility of a simple, non-invasive cortisol measure as a longitudinal, biological proxy of maternal stress experiences. This study has the potential to result in a more comprehensive understanding of the social and structural etiologies associated with maternal stress and poor maternal and infant health outcomes. These findings will be of interest to policy makers as well as to researchers who seek to understand the connections between society, culture, and biology.

该奖项支持的研究将通过母亲压力和怀孕结果（特别是早产）的透镜调查文化和生物学之间的关系。以前的研究表明，早产率的一些变化以及新生儿的健康状况可以归因于社会和文化因素。然而，人们对贫困、种族主义和其他社会决定因素与分娩时胎龄之间的联系机制知之甚少。俄勒冈州州立大学人类学博士生冬青霍兰将在梅丽莎·切尼博士的监督下调查母亲压力可能是一个联系因素的可能性。这是一个重要的问题，因为全球每年估计有1500万婴儿早产。早产，定义为胎龄37周之前的活产，是五岁以下儿童死亡的主要原因，并与分娩后存活的儿童的终身慢性健康问题有关。这项研究将在波多黎各进行，那里的早产率在整个美国司法管辖区最高。此外，其他地方与早产有关的最常见的流行病学变量（如产妇年龄、吸烟、产妇教育、头三个月产前护理和缺乏健康保险）并不能解释波多黎各的早产率。然而，最近，研究人员提出了一种新的调查途径：产妇压力和早产之间可能存在的关系，尽管迄今为止，由于方法上的限制，这些研究的结果一直是模棱两可的。因此，霍兰将改进压力研究方法，以便更可靠地描述和检查文化和生物因素之间的关系。她将收集社会和生物学方法的混合数据，包括：参与者观察;管理科恩感知压力量表（PSS）和修订的产前窘迫问卷（RPDQ）的波多黎各版本;头发皮质醇浓度（HCC）采样;和半结构化产后退出访谈。 她将使用探索性的，半结构化的采访，最初的25名参与者确定产妇压力的文化模式。在另外100名女性中，将在妊娠期间的三个时间点（10至12周，22至24周和34至36周）评估PSS，RPDQ和HCC，以确定三个月内压力体验和激素的趋势。产后4 - 8周将进行一次离职面谈，并从这100名参与者中收集第四份也是最后一份头发皮质醇样本。头发皮质醇浓度（HCCs）将被用来调查一个简单的，非侵入性的皮质醇测量作为一个纵向的，产妇压力的经验，生物代理的效用。这项研究有可能导致更全面地了解与孕产妇压力和孕产妇和婴儿健康状况不佳相关的社会和结构病因。这些发现将对政策制定者以及寻求了解社会，文化和生物学之间联系的研究人员感兴趣。