RII Track-2 FEC: Probing and Understanding the Brain: Micro and Macro Dynamics of Seizure and Memory Networks

RII Track-2 FEC：探测和理解大脑：癫痫发作和记忆网络的微观和宏观动力学

• 批准号: 1632891
• 负责人: Leonidas Iasemidis
• 金额: $ 600万
• 依托单位: Louisiana Tech University
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1632891&HistoricalAwards=false
• 关键词: RII; Track; FEC; Probing; Understanding

Non-technical DescriptionTwelve researchers across three institutions in three states (Louisiana, Arkansas, and Alabama) will collaborate on this brain research, and develop a foundation for the region as a hub for interdisciplinary, collaborative research activity in the neurosciences. This work will focus on understanding the initiation of epileptic brain seizures and longer-term impacts on brain function such as memory. Epileptic seizures directly impact roughly 1% of humans, and have indirect impacts on loved ones and caregivers as well as economic impacts on society. Epilepsy has been called a ?window to brain function? because the condition impairs different brain functions depending on the location of the seizure in the brain and the impacted network of neurons, and because it provides a unique opportunity to study an impaired brain?s function over time and space. The project will develop minimally invasive implantable sensors that can be used for monitoring before, during, and for several months following seizure events. Researchers will relate changes occurring during seizure events with those observed in the intervals between events. The project includes hiring four new faculty, design and purchase of equipment, development of new undergraduate and graduate courses, recruitment and training of a diverse student population to better reflect the regional community, and new student research and workforce opportunities. Technical Description The activities of the team across three institutions (Louisiana Tech University, the University of Arkansas, and the University of Alabama) are organized under four thrust areas that focus on recording and analysis of electrical activity, magnetic activity, neurochemical and optical signals, and memory function of the brain. A series of coordinated and synergistic investigations will be conducted using innovative methods and tools designed to probe brain function at the molecular, cellular, and macro levels in epileptic rats and human subjects. Patients with focal epilepsy, during their presurgical evaluation, will undergo implantation of intracranial electroencephalographic (iEEG) electrodes for subsequent long-term (days) recording and monitoring of their spontaneous seizures. Non-invasive magnetoencephalographic (MEG) imaging is also used to provide important complementary information on the electromagnetic activity of the brain. This collaboration will advance research and also result in the creation of unique databases of human and animal data from the participating institutions.

非技术描述来自三个州(路易斯安那州、阿肯色州和阿拉巴马州)的三个机构的12名研究人员将在这项大脑研究上进行合作，并为该地区建立一个基础，使其成为神经科学中跨学科、协作研究活动的中心。这项工作将集中在了解癫痫脑癫痫发作的启动和对大脑功能(如记忆)的长期影响。癫痫发作直接影响大约1%的人类，并对亲人和照顾者产生间接影响，并对社会产生经济影响。癫痫被称为大脑功能的窗口？因为这种情况会损害不同的大脑功能，这取决于癫痫在大脑中的位置和受影响的神经元网络，也因为它为研究受损的大脑提供了一个独特的机会-S随时间和空间的功能。该项目将开发微创可植入传感器，可用于在癫痫发作之前、期间和之后的几个月内进行监测。研究人员将把癫痫发作期间发生的变化与事件之间的间隔时间观察到的变化联系起来。该项目包括招聘四名新教师，设计和购买设备，开发新的本科生和研究生课程，招聘和培训多样化的学生群体，以更好地反映地区社区，以及新的学生研究和劳动力机会。该小组在三个机构(路易斯安那理工大学、阿肯色大学和阿拉巴马大学)的活动被组织在四个主要领域，重点是记录和分析大脑的电活动、磁活动、神经化学和光学信号以及记忆功能。将使用创新的方法和工具进行一系列协调和协同的研究，旨在探索癫痫大鼠和人类受试者在分子、细胞和宏观水平上的脑功能。局灶性癫痫患者在术前评估期间，将植入颅内脑电(IEEG)电极，以便随后长期(天)记录和监测他们的自发发作。无创脑磁图(MEG)成像也被用来提供关于大脑电磁活动的重要补充信息。这一合作将推动研究，并导致从参与机构创建独特的人类和动物数据数据库。