I-Corps: Quantitative Diagnosis of Sperm Quality

I-Corps：精子质量的定量诊断

• 批准号: 1640274
• 负责人: Tomer Avidor-Reiss
• 金额: $ 5万
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2017-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1640274&HistoricalAwards=false
• 关键词: Corps; Quantitative; Diagnosis; Sperm; Quality

Sperm quality determines a man's ability to conceive, but many men do not know their chances of having a baby or why they are infertile. This I-Corps team proposes to develop a technology that provides men a new way to assess their sperm quality and fertility. Ultimately, it helps the infertile couples that are seeking treatment options. Furthermore, assessing sperm quality is also important to sperm banks, fertility clinics, and farmers that produce livestock because the ability to select the best quality sperm leads to an increase in productivity and profit. Currently, only some aspects of sperm quality can be determined, and the proposed project expands the parameters of sperm analysis, leading to better sperm evaluation and identification of unrecognized infertility. Since the technology identifies a new type of infertility, it has the potential to be a disruptive innovation in the reproductive medicine market.One out of eight couples is infertile, affecting millions of people in the USA alone. With current technology, approximately 20% of these couples do not know the basis of their infertility and cannot attribute it to either the man or the woman. This rate of infertility describes a very broad and compelling market need. The technology provides physicians in fertility clinics the ability to identify whether male patients are infertile and predict the success of in vitro fertilization. Since treatments are usually not covered by insurance and have only a 25% chance of success, anything that can increase the predictability of success would be an important way to maintain physicians' reputations and success ratios. Other potential market areas might be agricultural; farms that breed livestock such as turkey, dairy cattle, and pigs, by using artificial insemination. This technology would provide the farmer a diagnostic tool to assess semen quality to increase agricultural productivity. Furthermore, sperm banks could use our technology to predict the quality of the sperm they sell. Overall the technology would significantly enhance the assessment of sperm quality and capability to produce a healthy baby or offspring. Using I-Corps funding this team will determine specific areas where the proposed technology can be utilized. In order to investigate the customers' needs, such as accuracy level, price, and ease of use, this team will look for potential customers who have experienced the current technology and customers who are not satisfied with the current technology.

精子的质量决定了一个男人怀孕的能力，但许多男人不知道他们生孩子的机会，也不知道他们为什么不孕。这个I-Corps团队提议开发一种技术，为男性提供一种评估精子质量和生育能力的新方法。最终，它帮助不孕夫妇寻求治疗方案。此外，评估精子质量对精子库、生育诊所和养殖牲畜的农民也很重要，因为选择最优质精子的能力会提高生产力和利润。目前，只能确定精子质量的某些方面，而本项目扩大了精子分析的参数，从而更好地评估精子和识别未识别的不孕症。由于这项技术确定了一种新型的不孕症，它有可能成为生殖医学市场上的一项颠覆性创新。每八对夫妇中就有一对不孕不育，仅在美国就有数百万人受到影响。以目前的技术，这些夫妇中大约有20%不知道他们不孕的基础，也不能将其归因于男性或女性。这个不孕症的比率说明了一个非常广泛和令人信服的市场需求。这项技术为生育诊所的医生提供了识别男性患者是否不育的能力，并预测体外受精的成功。由于治疗通常不在保险范围内，而且成功率只有25%，任何能够提高成功可预测性的方法都将是维护医生声誉和成功率的重要方法。其他潜在的市场领域可能是农业；用人工授精方法饲养火鸡、奶牛和猪等家畜的农场。这项技术将为农民提供一种评估精液质量的诊断工具，以提高农业生产力。此外，精子库可以使用我们的技术来预测他们出售的精子的质量。总的来说，这项技术将大大提高对精子质量和生育健康婴儿或后代能力的评估。利用I-Corps的资金，该团队将确定可以利用拟议技术的具体领域。为了调查客户的需求，例如精度水平，价格和易用性，该团队将寻找体验过当前技术的潜在客户和对当前技术不满意的客户。