Centriole Inheritance During Reproduction

繁殖过程中的中心粒遗传

• 批准号: 1121176
• 负责人: Tomer Avidor-Reiss
• 金额: $ 74.96万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2013-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1121176&HistoricalAwards=false
• 关键词: Centriole; Inheritance; During; Reproduction

Intellectual MeritCentrioles are conserved microtubule-based organelles that play essential roles in numerous cellular functions and in an organism's development. A cell requires exactly two centrioles in order to normally divide and function. Thus, it is important that centriole number is precisely regulated. However, in many animals, it appears that the unfertilized oocyte lacks any centrioles and it inherits only one centriole from the sperm. As a fertilized oocyte has two centrioles, it acquires the second centriole via an unidentified mechanism. The goal of this project is to better understand how the second centriole is acquired using Drosophila melanogaster as a model system.Broader ImpactsAs well as answering basic Developmental and Cell Biology questions, this project will provide many developing and novice scientists (e.g., undergraduate and high school students) an opportunity to experience laboratory research at a top tier institution. Over the past five years, the Avidor-Reiss laboratory has developed and executed a student outreach program that provides students from Boston-area high schools and colleges with short term (2 - 3 month) or long-term (2 - 3 year) laboratory internships where they can gain direct training and exposure to research in the biological sciences. This is an exceptional and ideal opportunity for a young person who is considering a career in science. In conclusion, the proposed research will help educate and inspire the next generation of researchers.

智力优势中心粒是一种保守的基于微管的细胞器，在许多细胞功能和生物体的发育中发挥重要作用。 一个细胞需要两个中心粒才能正常分裂和发挥功能。 因此，重要的是，中心粒数是精确调节。 然而，在许多动物中，未受精的卵母细胞似乎缺乏任何中心粒，它只从精子继承了一个中心粒。 由于受精卵母细胞有两个中心粒，它通过一种未知的机制获得第二个中心粒。 本项目的目标是更好地了解如何使用果蝇作为模型系统获得第二中心粒。更广泛的影响以及回答基本的发育和细胞生物学问题，本项目将提供许多发展和新手科学家（例如，本科生和高中生）有机会在顶级机构体验实验室研究。 在过去的五年中，Avidor-Reiss实验室开发并执行了一项学生拓展计划，为波士顿地区高中和大学的学生提供短期（2 - 3个月）或长期（2 - 3年）的实验室实习，在那里他们可以获得直接的培训和接触生物科学研究。这是一个特殊的和理想的机会，一个年轻人谁正在考虑在科学事业。 总之，拟议的研究将有助于教育和激励下一代的研究人员。