Functional characterization of parvins on the regulation of endothelial actin cyto skeleton during angiogenesis Role of integrin/parvin-signaling in the neurovascular unit during central nervous system development

Parvins 在血管生成过程中调节内皮肌动蛋白细胞骨架的功能特征整合素/parvin 信号在中枢神经系统发育过程中神经血管单元中的作用

• 批准号: 226461155
• 负责人: Dr. Eloi Montanez Miralles
• 金额: --
• 依托单位: Institut für Kardiovaskuläre Physiologie und Pathophysiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/226461155?language=en
• 关键词: Functional; characterization; parvins; regulation; endothelial

The overall aim of the research project is to deepen our understanding of the molecular mechanisms controlling cell-extracellular matrix (ECM) interactions, and how the interplay between different cell types governs vascular morphogenesis, and tissue homeostasis and function. As an experimental system we use the neurovascular unit (NVU) of the central nervous system (CNS) in mice. The NVU consist of an endothelial cell (EC) monolayer, sealed by tight junctions (TJ) and resting on a basal lamina, integrated pericytes, astrocytes and occasionally neuronal terminals. The dynamic interactions within the NVU are critical for the homeostasis of the CNS, and disruption of the NVU integrity is associated with neurological pathologies, including stroke, intracerebral hemorrhage and ocular diseases. The proposed project focuses on the role of integrin/parvin-signaling within the NVU in physiological conditions.

该研究项目的总体目标是加深我们对控制细胞-细胞外基质（ECM）相互作用的分子机制的理解，以及不同细胞类型之间的相互作用如何控制血管形态发生，组织稳态和功能。作为实验系统，我们使用小鼠中枢神经系统（CNS）的神经血管单位（NVU）。NVU由内皮细胞（EC）单层组成，由紧密连接（TJ）密封并位于基底层上，整合的周细胞，星形胶质细胞和偶尔的神经元终末。NVU内的动态相互作用对于CNS的稳态是至关重要的，并且NVU完整性的破坏与神经病理学相关，包括中风、脑内出血和眼部疾病。该项目的重点是整合素/parvin信号转导在生理条件下的NVU内的作用。