SBIR Phase I: Manufacturing of Natural Isoeugenol and Ferulate from non-food biomass as a precursor to biobased vanillin.

SBIR 第一阶段：利用非食品生物质生产天然异丁香酚和阿魏酸酯，作为生物基香草醛的前体。

• 批准号: 1647923
• 负责人: Ian Klein
• 金额: $ 22.5万
• 依托单位: Spero Energy, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1647923&HistoricalAwards=false
• 关键词: SBIR; Phase; Manufacturing; Natural; Isoeugenol

The broader impact/commercial potential of this Small Business Innovative Research Phase I project is the development of a process for the sustainable production of high value chemicals (HVCs) from non-food biomass. The resulting HVCs, isoeugenol and ferulate, are the starting materials used in the flavor and fragrance industry for the manufacture of natural vanillin. Today, only a small percentage of the 18,000 metric tons of vanillin used annually is produced from natural sources. The clear majority of vanillin is produced by harsh chemical derivatization of petroleum feedstock. Using the innovative technology developed by Spero Energy, Inc., non-food biomass can be used to produce the starting materials for natural vanillin production. Sustainable manufacturing of natural isoeugenol and ferulate from non-food biomass will serve to advance the US bioeconomy while supplying essential starting materials to the $600 million a year and growing vanillin industry.The technical objectives of this Small Business Innovation Research Phase I project are to demonstrate the scalability of Spero?s technology for production of natural isoeugenol and ferulate from non-food biomass. Increasing consumer demand for products containing natural flavors and fragrances, and the associated premium prices relative to artificial alternatives, offers a promising venue to advance the US bioeconomy. Spero Energy, Inc. has developed natural and sustainable methods to produce isoeugenol and ferulate, key starting materials for the synthesis of natural vanillin. Vanillin is one of the most widely utilized flavors with a market value of over $600 million per year. Key research objectives include scaling production volumes of ferulate and isoeugenol, followed by a detailed study of purification methods, biochemical conversion to natural vanillin, and validation of the organoleptic properties of the resulting vanillin. This work is anticipated to yield key reaction and purification data which will be analyzed with ASPEN modeling in preparation for pilot scale production in Phase II.

这个小企业创新研究第一阶段项目的更广泛的影响/商业潜力是开发一种从非食品生物质中可持续生产高价值化学品（HVC）的工艺。产生的HVC（异丁香酚和阿魏酸）是香精香料行业用于生产天然香草醛的起始原料。如今，每年使用的18，000公吨香草醛中只有一小部分是从天然来源生产的。绝大多数香草醛是通过石油原料的苛刻化学衍生化产生的。利用斯佩罗能源公司开发的创新技术，非食品生物质可用于生产天然香草醛生产的原料。天然异丁香酚和阿魏酸从非食品生物质的可持续制造将有助于推进美国生物经济，同时提供必要的起始材料，以6亿美元，每年和不断增长的香草醛industrial.The技术目标的小企业创新研究第一阶段项目是展示Spero的可扩展性？介绍了利用非食用生物质生产天然异丁香酚和阿魏酸的技术。消费者对含有天然香料和芳香剂的产品的需求不断增加，以及相对于人工替代品的相关溢价，为推动美国生物经济提供了一个有希望的场所。Spero能源公司开发了天然和可持续的方法来生产异丁香酚和阿魏酸，这是合成天然香草醛的关键起始材料。香草醛是最广泛使用的香料之一，每年的市场价值超过6亿美元。主要研究目标包括阿魏酸和异丁香酚的规模化生产量，随后详细研究纯化方法，生物化学转化为天然香草醛，并验证所得香草醛的感官特性。预计这项工作将产生关键的反应和纯化数据，这些数据将用白杨建模进行分析，为第II阶段的中试规模生产做准备。