STTR Phase I: Multipass Sensing for Ultrahigh Resolution Particle Characterization

STTR 第一阶段：用于超高分辨率颗粒表征的多通道传感

• 批准号: 1648790
• 负责人: Anna Schibel
• 金额: $ 22.5万
• 依托单位: Electronic Bio Sciences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1648790&HistoricalAwards=false
• 关键词: STTR; Phase; Multipass; Sensing; Ultrahigh

This Small Business Technology Transfer Phase I project will generate a new nanoparticle characterization system with the ability to assess the size, length-to-width ratio, zeta potential, and concentration of solution-based nanoparticle (or molecular) samples with state-of-the-art accuracy, precision, and resolution, all on a single platform. The primary need for new nanoparticle characterization instrumentation is driven by the increasing utility and benefit of nanoparticles in healthcare and medicine, including nanoparticle drug delivery, nanoscale particle/molecule drugs and therapies, and nanoparticle-based imaging and diagnostics agents. The prototype system developed under this program will be targeted toward the general nanoparticle characterization market, presently estimated at ~$500M, which includes applications in the pharmaceutical and biomedical industries, nanoparticle manufacturing, R&D, and academic research. The developed system will not only improve solution-based nanoparticle characterization, but streamline characterization processes and provide new insights with regard to sample characterization, optimization, and utilization within the nanoparticle field.The intellectual merit of this project lies in the development of a completely new and innovative particle characterization system for which there is no equivalent, capable of automated, high-resolution, solution-based particle assessments at the single-molecule level. The developed system will enable the ability to quickly characterize a large number (hundreds to thousands) of particles/molecules in solution in order to assess the distribution within the sample. These goals will be reached by developing, building, and validating a complete and fully functioning alpha-prototype system and then demonstrating the functionality and utility of the new system by characterizing solution-based particle- and molecule-containing samples that otherwise cannot be characterized with high resolution. Upon completing this program, an entirely new nanoparticle characterization instrument will be developed and validated that is ready for initial introductions into the nanoparticle field via industrial and academic communities.

这个小型企业技术转移第一阶段项目将产生一种新的纳米颗粒表征系统，能够在单一平台上以最先进的精度、精密度和分辨率评估基于溶液的纳米颗粒(或分子)样品的大小、长宽比、Zeta电位和浓度。对新的纳米颗粒表征仪器的主要需求是由于纳米颗粒在医疗保健和医学中日益增长的实用性和益处，包括纳米颗粒药物输送、纳米颗粒/分子药物和疗法以及基于纳米颗粒的成像和诊断试剂。根据该计划开发的原型系统将面向一般纳米颗粒表征市场，目前估计市场价值约为5亿美元，包括在制药和生物医学行业、纳米颗粒制造、研发和学术研究中的应用。开发的系统不仅将改进基于溶液的纳米颗粒表征，而且将简化表征过程，并为纳米颗粒领域内的样品表征、优化和利用提供新的见解。该项目的智力优势在于开发了一种全新的、创新的颗粒表征系统，该系统没有同等的、能够在单分子水平上进行自动化、高分辨率、基于溶液的颗粒评估。开发的系统将能够快速表征大量(数百至数千)溶液中的颗粒/分子，以便评估样品中的分布。这些目标将通过开发、构建和验证一个完整和全功能的阿尔法原型系统来实现，然后通过表征基于溶液的颗粒和分子样品来展示新系统的功能和用途，否则无法用高分辨率表征这些样品。完成这一计划后，将开发和验证一种全新的纳米颗粒表征仪器，准备通过工业界和学术界初步引入纳米颗粒领域。