I-Corps: Degradable magnesium/polymer barrier membranes

I-Corps：可降解镁/聚合物屏障膜

• 批准号: 1651930
• 负责人: Charles Sfeir
• 金额: $ 5万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-11-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1651930&HistoricalAwards=false
• 关键词: Corps; Degradable; magnesium; polymer; barrier

The broader impact/commercial application of this I-Corps project is faster and less painful bone grafting experiences for patients world-wide. Patients undergo millions of bone grafting procedures every year prior to dental implant placement, to fuse spinal vertebrae and following traumatic injuries such as combat blasts and motor vehicle accidents. Currently used bone grafting materials provide unreliable outcomes requiring repeat bone grafting procedures at substantial added costs to patients and the healthcare system. Development of improved bone grafting materials represents a significant commercial differentiation by enhancing the bone grafting patient experience.This I-Corps project is focused on better defining the commercial opportunity for a degradable magnesium-based barrier membrane for primary use in dental bone grafting procedures. Previously conducted NSF-funded research demonstrated that degradable magnesium devices enhanced bone regeneration following injury. This finding led to the assessment of a degradable magnesium-based barrier membrane in a dental defect which regenerated more bone than currently used materials. The current focus of the research is defining the economics surrounding the use of barrier membranes in dental bone grafting procedures and the key design criteria for developing such devices.

这个i-Corps项目的更广泛的影响/商业应用是为世界各地的患者提供更快、更少痛苦的骨移植体验。患者在植入牙科植物之前，每年都要接受数百万次的植骨手术，以融合脊柱，并在战斗爆炸和机动车事故等创伤后接受植骨手术。目前使用的骨移植材料提供的结果不可靠，需要重复骨移植程序，大大增加了患者和医疗保健系统的成本。改进的骨移植材料的开发通过提高骨移植患者的体验代表着显著的商业差异化。这个i-Corps项目专注于更好地确定可降解的镁基屏障膜的商业机会，主要用于牙科骨移植程序。之前进行的由美国国家科学基金会资助的研究表明，可降解的镁设备可以促进损伤后的骨再生。这一发现导致了一种可降解的镁基屏障膜在牙科缺损中的评估，这种膜再生的骨比目前使用的材料更多。目前的研究重点是确定在牙科骨移植过程中使用屏障膜的经济性，以及开发这种装置的关键设计标准。