Developmental evolution of sex-specific mechanisms underlying the Retinoblastoma pathway in the control of gametic cell fate and differentiation in plants

视网膜母细胞瘤途径控制植物配子细胞命运和分化的性别特异性机制的发育进化

• 批准号: 227627347
• 负责人: Dr. Amal J. Johnston
• 金额: --
• 依托单位: Institut für Biologie
• 依托单位国家: 德国
• 项目类别: Independent Junior Research Groups
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/227627347?language=en
• 关键词: Developmental; evolution; sex; specific; mechanisms

It is an enigma how the highly specialised higher plants of today evolved from lower plants or other early life forms. Whereas the haploid leafy gametophyte dominated in lower lineages such as mosses (eg. Physcomitrella), the flowering plants (e.g. Arabidopsis) have a dominant diploid leafy sporophyte and dependent gamete-bearing haploid gametophytes, which are also known as the male and female germlines. Concomitant with the shift in dominance from gametophyte to sporophyte along the evolution of the land plants from Paleozoic to Cenozoic era, neo- and/or subfunctionalisation in gene regulatory networks is anticipated. The proposed Emmy Noether research group will examine how patterning and cell differentiation of germlines regulated by evolutionarily ancient transcription factor modules co-evolved in two divergent plant model systems Arabidopsis and Physcomitrella. In particular, adaptive evolution of sex-specific, genetic and epigenetic mechanisms underlying plant Retinoblastoma regulatory pathways during germline development will be investigated.

当今高度专业化的高等植物是如何从低等植物或其他早期生命形式进化而来的，这是一个谜。单倍体叶状配子体在低等谱系中占主导地位，例如苔藓（例如立碗藓），而开花植物（例如拟南芥）则具有优势二倍体叶状孢子体和依赖配子的单倍体配子体，也称为雄性和雌性种系。随着陆地植物从古生代到新生代的进化，从配子体到孢子体的优势转变，预计基因调控网络中的新功能化和/或亚功能化。拟定的艾美·诺特研究小组将研究在拟南芥和立碗藓这两个不同的植物模型系统中，进化古老的转录因子模块如何共同进化调控种系的模式和细胞分化。特别是，将研究种系发育过程中植物视网膜母细胞瘤调控途径的性别特异性、遗传和表观遗传机制的适应性进化。