Engineering New REU Approaches to Challenges in MultiTERM
Engineering New REU Approaches to Challenges in MultiTERM
批准号:
1659663
负责人:
Anthony Atala
金额:
$36.64万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-10-01 至 2021-09-30
中文摘要
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英文摘要
This three year Research Experiences for Undergraduates (REU) Site program, Engineering New REU Approaches to Challenges in MultiTERM at the Wake Forest Institute for Regenerative Medicine (WFIRM), will provide research opportunities at the interface of engineering and biology in challenging areas of tissue engineering and regenerative medicine (TERM) to a diverse cohort of undergraduate students from underrepresented groups with limited access to research facilities. The proposed research projects span multiple physiological systems (cardiovascular, musculoskeletal, urological, and endocrine), providing REU students a unique opportunity to become highly skilled problem solvers by appreciating generalized, system-independent approaches with many of the projects identified as high priority by NSF and DoD. Despite early successes, four main challenges remain spanning: 1) biomaterials, 2) cell sources, 3) vascularization and 4) enabling technologies such as cell delivery devices, 3D bioprinting and tissue bioreactors. REU projects will help address these challenges. WFIRM will host 10 undergraduate students over 10 summer weeks where they will engage in highly interdisciplinary and challenging areas of TERM research. Outcome objectives of the program emphasize: 1) development of interest and excitement for team-based-studies and advanced education; 2) skill transference and hands-on exposure to modern instrumentation and techniques as well as rigorous analysis; 3) enhanced verbal and written communication skills emphasizing abilities to communicate across disciplines in lay and technical terms and in formally presenting in writing (for the scientific literature) and speaking (for scientific meetings); and, ultimately, 4) to initiate socialization into the very important process of growth from dependent to independent researcher status. The REU experience is supplemented with additional program elements and education on the research process, hands-on instrumentation training, workshops on bioethics and responsible conduct of research, effective oral and written communications workshops, professional development and career opportunities topics. To increase program impact and sense of community, REU participants will also participate in non-research and outreach activities at WFIRM and with URM partners, providing forums to discuss implications of STEM advances to the larger society, while fostering networking with other students, engineers, scientists and educators. All students will present their research findings several times over the summer and in oral and poster format at a final research day event. Opportunities to attend and present at local and national meetings is also emphasized.
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科研奖励(0)
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Administration of FVIII-Expressing Human Placental Cells to Juvenile Sheep Yields Multi- Organ Engraftment, Therapeutic Plasma FVIII Levels and Alter Immune Signaling Pathways to Evade FVIII Inhibitor Induction
将表达 FVIII 的人胎盘细胞给予幼年绵羊可实现多器官移植、治疗性血浆 FVIII 水平并改变免疫信号传导途径以逃避 FVIII 抑制剂诱导
DOI:
--
发表时间:
2021
期刊:
ASH
影响因子:
--
作者:
[Trevisan, Brady, Rodriguez, Martin, Dizon, Jacqueline, George, Sunil, Shields, Jordan, Lankford, Shannon, Combs, Rebessa, Owen, John, Atala, Anthony, Doering, Christopher]
通讯作者:
Doering, Christopher
Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis
人胎盘干细胞疗法可改善实验性坏死性小肠结肠炎
DOI:
10.1152/ajpgi.00369.2020
发表时间:
2021
期刊:
American Journal of Physiology-Gastrointestinal and Liver Physiology
影响因子:
4.5
作者:
[Weis, Victoria G., Deal, Anna C., Mekkey, Gehad, Clouse, Cara, Gaffley, Michaela, Whitaker, Emily, Peeler, Cole B., Weis, Jared A., Schwartz, Marshall Z., Atala, Anthony]
通讯作者:
Atala, Anthony
Using a Human Liver Tissue Equivalent (hLTE) Platform to Define the Functional Impact of Liver-Directed AAV Gene Therapy
使用人类肝脏组织等效物 (hLTE) 平台定义肝脏定向 AAV 基因治疗的功能影响
DOI:
--
发表时间:
2021
期刊:
ASH
影响因子:
--
作者:
[Ramamurthy, R, Zheng, WT, George, S, Wan, M, Zhou, Y, Bishop, C, Atala, A, Porada, C, Almeida-Porada, G]
通讯作者:
Almeida-Porada, G
DOI:
10.1038/s41598-020-66487-8
发表时间:
2020-06-17
期刊:
SCIENTIFIC REPORTS
影响因子:
4.6
作者:
[Nzou, Goodwell, Wicks, Robert T., Atala, Anthony J.]
通讯作者:
Atala, Anthony J.
REU Site: Enabling Technologies and New REU Approaches to Engineer Complex Tissues
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批准号:2243993
-
项目类别:Standard Grant
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资助金额:$38.74万
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财政年份:2023
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负责人:Anthony Atala
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依托单位:
海外基金