REU Site: Enabling Technologies and New REU Approaches to Engineer Complex Tissues

REU 网站：工程复杂组织的支持技术和 REU 新方法

• 批准号: 2243993
• 负责人: Anthony Atala
• 金额: $ 38.74万
• 依托单位: Wake Forest University School of Medicine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-10-01 至 2026-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2243993&HistoricalAwards=false
• 关键词: REU; Site; Enabling; Technologies; New

This three-year renewal REU Site, Enabling Technologies and New REU Approaches to Engineer Complex Tissues, will engage diverse cohorts of 10 undergraduate students each summer in highly collaborative, team-based 10-week multidisciplinary research projects in regenerative medicine at the Wake Forest Institute for Regenerative Medicine (WFIRM). A challenge facing the regenerative medicine field and the broader STEM disciplines is developing the next generation of skilled bioengineers. Regenerative medicine is a multidisciplinary field involving engineering and other STEM disciplines. Students will focus on learning about enabling technologies and biomanufacturing approaches in regenerative medicine and the emerging field of biofabrication. The REU experience is supplemented with additional program activities and education on the research process, hands-on instrumentation, workshops on bioethics, responsible conduct of research, effective oral and written communication, professional development, networking, and career opportunities topics. WFIRM has been at the forefront in RM research for nearly two decades and is an internationally recognized center of excellence in research and training.This renewal REU Site, Enabling Technologies and New REU Approaches to Engineer Complex Tissues, will engage diverse cohorts of 10 undergraduate students each summer for three years in highly collaborative, team-based 10-week multidisciplinary research projects in regenerative medicine (RM) at the Wake Forest Institute for Regenerative Medicine (WFIRM). Students will learn about enabling technologies and biomanufacturing approaches and the emerging field of biofabrication. This REU, emphasizing RM enabling technologies and biomanufacturing, is focused on two convergent research areas: 1) enabling technologies biomanufacturing and biofabrication (3D bioprinting, bioreactors, encapsulation and bioengineering of multi-cellular tissue constructs (organoids/body-on-a-chip) as modeling platforms and 2) stem cells/gene editing as applied to engineering one or more tissue/organ application. The REU experience is supplemented with additional program elements and education on the research process, hands-on instrumentation, workshops on bioethics, responsible conduct of research, effective oral and written communication, professional development, networking, and career opportunities topics. Also included is an introductory course to familiarize students with the essentials of the regenerative medicine field and seminars on “hot” topics in the field. All students will present their research findings throughout the summer and at a final research day symposium. WFIRM has been at the forefront in RM research for nearly two decades and is an internationally recognized center of excellence in research and training.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个为期三年的更新REU站点，使能技术和新的REU方法来工程复杂组织，将吸引不同的10名本科生每年夏天在维克森林再生医学研究所（WFIRM）进行高度协作，以团队为基础的10周再生医学多学科研究项目。再生医学领域和更广泛的STEM学科面临的挑战是培养下一代熟练的生物工程师。再生医学是一个涉及工程和其他STEM学科的多学科领域。学生将重点学习再生医学和新兴生物制造领域的使能技术和生物制造方法。REU的经验补充了额外的项目活动和研究过程的教育，动手仪器，生物伦理学研讨会，负责任的研究行为，有效的口头和书面沟通，专业发展，网络和职业机会主题。近二十年来，WFIRM一直处于RM研究的前沿，是国际公认的卓越研究和培训中心。这个更新的REU站点，使能技术和新的REU方法来工程复杂组织，将在三年的时间里，每年夏天在维克森林再生医学研究所（WFIRM）吸引10名不同的本科生进行高度协作，以团队为基础的10周再生医学多学科研究项目。学生将学习使能技术和生物制造方法以及新兴的生物制造领域。该REU强调RM使能技术和生物制造，专注于两个融合的研究领域：1)使能技术生物制造和生物制造（3D生物打印，生物反应器，多细胞组织构建（类器官/芯片上的身体）的封装和生物工程作为建模平台；2）干细胞/基因编辑应用于工程一个或多个组织/器官应用。REU的经验补充了额外的项目元素和研究过程教育，动手仪器，生物伦理研讨会，负责任的研究行为，有效的口头和书面沟通，专业发展，网络和职业机会主题。还包括一个入门课程，让学生熟悉再生医学领域的基本知识，以及该领域“热门”话题的研讨会。所有学生将在整个夏季和最后的研究日研讨会上展示他们的研究成果。近二十年来，WFIRM一直处于RM研究的前沿，是国际公认的卓越研究和培训中心。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。