Targeting the brain through the gut: bottom-up mechanisms of eating behavior (A01)

通过肠道瞄准大脑：自下而上的饮食行为机制 (A01)

• 批准号: 227995651
• 金额: --
• 依托单位: Tagesklinik für kognitive Neurologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/227995651?language=en
• 关键词: Targeting; brain; through; gut; bottom

Based on results of the current funding period, we propose novel pathomechanistic links between visceral fat, low-grade inflammation and changes in brain structure and function in obesity, which in turn relate to differences in cognition. Analyses further indicate that the gut microbiota modulate eating behavior via short-chain fatty acids signaling. Our goal is to now translate these findings into novel obesity-treatment options that target body-brain communication. To this end, we plan to test the effects of a pre-biotic intervention over 26 weeks compared to placebo on food decision-making in a randomized controlled trial with 60 obese patients. Mechanistic insights will be gained through the integration of task-based fMRI, microbiota sequencing and metabolomics.

基于当前资助期的结果，我们提出了内脏脂肪，低度炎症与肥胖症大脑结构和功能变化之间的新病理机制联系，这反过来又与认知差异有关。分析进一步表明，肠道微生物群通过短链脂肪酸信号调节进食行为。我们的目标是现在将这些发现转化为针对身体-大脑通信的新型肥胖治疗方案。为此，我们计划在60名肥胖患者的随机对照试验中测试益生元干预与安慰剂相比在26周内对食物决策的影响。通过整合基于任务的功能磁共振成像，微生物群测序和代谢组学，将获得机制的见解。