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Research Initiation Award: Investigation of mechanisms underlying pathological rhythms in parkinsonian basal ganglia - A mathematical modeling study

研究启动奖：帕金森基底神经节病理节律机制的研究 - 数学建模研究

基本信息

批准号：
1700199
负责人：
Choongseok Park
金额：
$ 29.58万
依托单位：
North Carolina Agricultural & Technical State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1700199&HistoricalAwards=false
关键词：
Research Initiation Award Investigation mechanisms

项目摘要

Research Initiation Awards provide support for faculty at Historically Black Colleges and Universities who are building a research program. It is expected that the award helps to further the faculty member's research capability and effectiveness, improves research and teaching at his home institution, and involves undergraduate students in research experiences. The award to North Carolina A&T State University has potential broader and societal impact in a number of areas. The project focuses on developing a mathematical model to understand the mechanisms underlying deep brain stimulation, a therapy used in the treatment of Parkinson's disease. Undergraduate students as well as high school students will gain research experiences. The effectiveness of deep brain stimulation in Parkinson's disease has been linked to the destruction of pathological rhythmicity in basal ganglia. To find a more effective deep brain stimulation procedure, it is crucial to use appropriate neuronal network models that are able to produce intermittently synchronized oscillatory dynamics observed in parkinsonian patients. As the only excitatory nucleus in the basal ganglia, the subthalamic nucleus plays an important role in the dynamics of basal ganglia and is a standard target for deep brain stimulation in Parkinson's disease. Recent experiments have identified a set of ionic currents that are responsible for various rhythmic bursting patterns in subthalamic nucleus neurons. This research will develop a new computational model for the subthalamic nucleus that comprises key currents and then set up network models, namely an updated basal ganglia network model and an extended cortex-basal ganglia-thalamus model. By performing numerical and mathematical analyses, the research will study how intrinsic neuronal properties and network properties in basal ganglia incorporate to generate intermittently synchronized rhythms. This project will enhance the understanding of the mechanisms underlying pathological rhythms in parkinsonian basal ganglia and deep brain stimulation procedures. The research may also lead to the discovery of more effective methods to break the intermittently synchronized rhythms in parkinsonian states with a minimal amount of stimulation intervention.

研究启动奖为历史上黑人学院和大学的教师提供支持，他们正在建立一个研究项目。预计该奖项将有助于进一步提高教师的研究能力和效率，改善其所在机构的研究和教学，并使本科生参与研究经验。授予北卡罗来纳州AT州立大学的奖项在许多领域具有潜在的更广泛的社会影响。该项目的重点是开发一个数学模型，以了解深部脑刺激的机制，这是一种用于治疗帕金森病的疗法。本科生以及高中生将获得研究经验。脑深部电刺激治疗帕金森病的有效性与基底神经节中病理性节律的破坏有关。为了找到一个更有效的脑深部电刺激程序，它是至关重要的，使用适当的神经元网络模型，能够产生间歇性同步的振荡动力学帕金森病患者中观察到的。丘脑底核作为基底节中唯一的兴奋核团，在基底节动力学中起着重要作用，是帕金森病脑深部电刺激的标准靶点。最近的实验已经确定了一组离子电流，负责各种节奏的爆发模式在丘脑底核神经元。该研究将开发一种新的包含关键电流的丘脑底核计算模型，然后建立网络模型，即更新的基底神经节网络模型和扩展的皮质-基底神经节-丘脑模型。通过进行数值和数学分析，该研究将研究基底神经节中的内在神经元特性和网络特性如何结合以产生间歇性同步节律。本计画将增进对帕金森氏症基底神经节及脑深部电刺激手术之病理节律机制的了解。这项研究还可能导致发现更有效的方法，以最小量的刺激干预来打破帕金森病状态中的间歇性同步节律。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Activity Patterns of a Two-Timescale Neuronal Ring Model with Voltage-Dependent, Piecewise Smooth Inhibitory Coupling

具有电压依赖性分段平滑抑制耦合的两时间尺度神经元环模型的活动模式

DOI：
10.1137/21m1431679
发表时间：
2022
期刊：
SIAM Journal on Applied Dynamical Systems
影响因子：
2.1
作者：
Park, Choongseok;Rubin, Jonathan E.
通讯作者：
Rubin, Jonathan E.

SCALE-UP Instructional Redesign of a Calculus Course at an HBCU

HBCU 微积分课程的扩展教学重新设计

DOI：
10.31686/ijier.vol7.iss1.1279
发表时间：
2019
期刊：
International journal for innovation education and research
影响因子：
0
作者：
Varatharajah, Paramanathan;Clemence-Mkhope, D.P.;Oldham, Janis M.;Tankersley, Barbara;Kim, Seong-Tae;Clemence-Mkhope, Belinda G.;Cousins-Cooper, Kathy;Park, Choongseok
通讯作者：
Park, Choongseok

Mathematical model of subthalamic nucleus neuron: Characteristic activity patterns and bifurcation analysis

丘脑底核神经元的数学模型：特征活动模式和分叉分析