Role of Trib1 in Obesity and Metabolism – Tissue Specific Effects and Target Molecules (B07+)

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The gene tribbles homolog-1 (Trib1) was recently identified as one of the genes related to lipid metabolism and atherosclerosis. Given the observed significant metabolic changes in white adipose tissue and skeletal muscle of Trib1-deficient mice, the projects applies conditional knockout strategies to create mice specifically lacking Trib1 in adipose tissue and skeletal muscle. Metabolic and functional characterization of these models will elucidate how Trib1-depletion ameliorates insulin sensitivity, obesity associated adipose tissue dysfunction and ectopic fat deposition in skeletal muscle.