Role of Trib1 in Obesity and Metabolism – Tissue Specific Effects and Target Molecules (B07+)

Trib1 在肥胖和代谢中的作用 â 组织特异性效应和目标分子 (B07)

• 批准号: 228191311
• 金额: --
• 依托单位: Institut für Klinische Chemie und Laboratoriumsmedizin
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/228191311?language=en
• 关键词: Role; Trib1; Obesity; Metabolism; Tissue

The gene tribbles homolog-1 (Trib1) was recently identified as one of the genes related to lipid metabolism and atherosclerosis. Given the observed significant metabolic changes in white adipose tissue and skeletal muscle of Trib1-deficient mice, the projects applies conditional knockout strategies to create mice specifically lacking Trib1 in adipose tissue and skeletal muscle. Metabolic and functional characterization of these models will elucidate how Trib1-depletion ameliorates insulin sensitivity, obesity associated adipose tissue dysfunction and ectopic fat deposition in skeletal muscle.

Tribble Homolog-1(Tribble Homolog-1)基因是最近发现的与脂代谢和动脉粥样硬化相关的基因之一。考虑到观察到Trib1基因缺陷小鼠白色脂肪组织和骨骼肌中显著的代谢变化，该项目应用条件基因敲除策略来创造脂肪组织和骨骼肌中特别缺乏Trib1的小鼠。这些模型的代谢和功能特征将阐明Trib1缺失如何改善胰岛素敏感性、肥胖相关的脂肪组织功能障碍和骨骼肌中异位脂肪沉积。