NSF Postdoctoral Fellowship in Biology FY 2017: How does temperature affect pathogens, microbiota, and medicinal value of flowers for bumble bees?

2017 财年 NSF 生物学博士后奖学金：温度如何影响大黄蜂的病原体、微生物群和花的药用价值？

• 批准号: 1708945
• 负责人: Evan Palmer-Young
• 金额: $ 20.7万
• 依托单位: Palmer-Young Evan C
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1708945&HistoricalAwards=false
• 关键词: NSF; Postdoctoral; Fellowship; Biology; FY

This is an NSF Postdoctoral Research Fellowship in Biology, under the program Broadening Participation of Groups Under-represented in Biology. The fellow, Evan Palmer-Young, is conducting research and receiving training that is increasing the participation of groups underrepresented in biology. The fellow is being mentored by Quinn McFrederick at the University of California-Riverside. The fellow's research examines how temperature affects health of bumble bees that are infected with a common disease, which is very widespread in bee populations, and related to several human diseases. The goal is to see whether high temperatures will help bees rid themselves of infection, but also whether there are side effects of high temperatures that might harm beneficial bacteria that live in the bee gut. The health of bumble bees is important to society because wild bees are key pollinators of crops and wild plants, and many bee populations are declining. The question of how temperature affects disease, including both beneficial and harmful microbes, is important for many species that are living in warming climates. It is also important for human health, because humans use fever as a defense against infection, yet it is not known whether fever is harmful to beneficial bacteria that are important for human health. To promote the participation of groups underrepresented in biology, the Fellow will mentor undergraduate students on the diverse UC-Riverside campus (70% minority students) in independent research, and conduct outreach activities with the public.The project has three objectives designed to elucidate effects of increased temperature on interactions between bumble bees and their pathogens and symbionts. (1) Comparison of in vitro thermotolerance of symbiotic microbes and the trypanosomatid parasite Crithidia bombi, to generate hypotheses for how increased temperature affects infection in vivo. (2) In vivo test of how temperature elevation affects infection intensity and alters populations of core gut microbiota. (3) Evaluation of how temperature affects chemical profiles and antimicrobial properties of plant nectar and pollen. To promote participation of groups underrepresented in biology, the Fellow will: (1) Mentor research of undergraduates in the California Alliance for Minority Participation (2) Teach a course that introduces underclassmen to biology research and engages them in one of the Fellowship?s objectives. (3) Use Chinese and Spanish language skills to lead outreach events at the University and local library, to build appreciation for plants and pollinators.

这是NSF生物学博士后研究奖学金，根据扩大生物学中代表性不足的群体的参与计划。这位名叫Evan Palmer-Young的研究员正在进行研究并接受培训，以增加生物学中代表性不足的群体的参与。这位研究员正在接受加州大学河滨分校奎因·麦克弗雷德里克的指导。该研究员的研究探讨了温度如何影响感染了一种常见疾病的大黄蜂的健康，这种疾病在蜜蜂种群中非常普遍，并与几种人类疾病有关。目的是看看高温是否会帮助蜜蜂摆脱感染，以及高温是否会对生活在蜜蜂肠道中的有益细菌产生副作用。大黄蜂的健康对社会很重要，因为野生蜜蜂是农作物和野生植物的主要授粉者，许多蜜蜂种群正在减少。温度如何影响疾病的问题，包括有益和有害的微生物，对于生活在气候变暖的许多物种来说都很重要。它对人类健康也很重要，因为人类利用发烧作为对抗感染的防御手段，但目前尚不清楚发烧是否会对对人类健康重要的有益细菌有害。为了促进生物学中代表性不足的群体的参与，该研究员将指导多样化的加州大学河滨分校的本科生（70%的少数民族学生）进行独立研究，并与公众开展外联活动。该项目有三个目标，旨在阐明温度升高对熊蜂及其病原体和共生体之间相互作用的影响。(1)比较共生微生物和锥虫寄生虫熊虫的体外耐热性，以产生温度升高如何影响体内感染的假设。(2)温度升高如何影响感染强度并改变核心肠道微生物群的体内试验。(3)温度如何影响植物花蜜和花粉的化学特性和抗菌特性的评估。为了促进在生物学中代表性不足的群体的参与，研究员将：（1）指导加州少数民族参与联盟的本科生研究（2）教授一门课程，向低年级学生介绍生物学研究，并让他们参与其中一个奖学金？的目标。(3)使用中文和西班牙语技能在大学和当地图书馆领导外展活动，培养对植物和传粉者的欣赏。

项目成果

Temperature dependence of parasitic infection and gut bacterial communities in bumble bees

大黄蜂寄生虫感染和肠道细菌群落的温度依赖性

• DOI: 10.1111/1462-2920.14805
• 发表时间: 2019
• 期刊: Environmental Microbiology
• 影响因子: 5.1
• 作者: Palmer‐Young, Evan C.;Ngor, Lyna;Burciaga Nevarez, Rodrigo;Rothman, Jason A.;Raffel, Thomas R.;McFrederick, Quinn S.
• 通讯作者: McFrederick, Quinn S.

Temperature-mediated inhibition of a bumblebee parasite by an intestinal symbiont

肠道共生体对大黄蜂寄生虫的温度介导抑制

• DOI: 10.1098/rspb.2018.2041
• 发表时间: 2018
• 期刊: Proceedings of the Royal Society B: Biological Sciences
• 作者: Palmer-Young, Evan C.;Raffel, Thomas R.;McFrederick, Quinn S.
• 通讯作者: McFrederick, Quinn S.