CDS&E: Resolving Nonlinearity in Thin Film Chemical Analysis: Roughening, Matrix Effects and Chemical Damage

CDS

• 批准号: 1709667
• 负责人: Lev Gelb
• 金额: $ 34.5万
• 依托单位: University of Texas at Dallas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1709667&HistoricalAwards=false
• 关键词: CDS& Resolving; Nonlinearity; Thin; Film

This project is funded by the Chemical Measurement and Imaging program of the Chemistry Division. Professors Lev Gelb and Amy Walker of the University of Texas at Dallas are improving methods for interpreting surface chemical analysis data. Many methods for studying a surface or thin film involve blasting it with high-energy beams of electrons or ions. These approaches provide information about the atoms and molecules present, but also cause unwanted chemical reactions and surface roughening. This team is developing easy-to-use analysis software to account for these "nonlinear" effects. The result is that the quality of surface chemical analysis data is improved, and this advances research in fields ranging from energy, to electronics, to advanced materials, to biotechnology. Graduate and undergraduate students are trained in the critically important fields of surface characterization, data analysis, numerical methods, and high-performance computing. This project focuses on two types of nonlinearity in chemical imaging: quantitative modeling of matrix effects in secondary ion mass spectrometry (SIMS) imaging of organic surfaces, and resolution of chemical damage and roughening in x-ray photoelectron spectroscopy (XPS) depth profiling of complex oxides. Extraction of sample properties in the presence of these nonlinearities is addressed through physical modeling within a Bayesian framework, which is made possible through a combination of theoretical developments, modern computing power, improvements in experimental protocols, and physical understanding of the underlying phenomena. In order to promote the use and further development of advanced data analysis in chemical imaging, software developed in this project is freely distributed and promoted as a community resource, along with online exercises that illustrate its use and application. SIMS and XPS are widely used in many areas, so improving the performance of these and related techniques is a significant long-term benefit to society at large.

该项目由化学部的化学测量和成像计划资助。德克萨斯大学达拉斯分校的教授列夫·盖尔布和艾米·步行者正在改进解释表面化学分析数据的方法。许多研究表面或薄膜的方法都涉及用高能电子束或离子束对其进行爆破。这些方法提供了有关原子和分子的信息，但也会导致不必要的化学反应和表面粗糙化。该团队正在开发易于使用的分析软件来解释这些“非线性”效应。其结果是提高了表面化学分析数据的质量，这推动了从能源到电子，到先进材料，再到生物技术等领域的研究。研究生和本科生在表面表征，数据分析，数值方法和高性能计算的关键重要领域进行培训。该项目的重点是两种类型的非线性化学成像：定量建模的基质效应在二次离子质谱（西姆斯）成像的有机表面，和分辨率的化学损伤和粗糙化的x射线光电子能谱（XPS）深度剖析的复杂氧化物。在这些非线性的存在下，通过贝叶斯框架内的物理建模来解决样品特性的提取，这是通过理论发展，现代计算能力，实验方案的改进和对潜在现象的物理理解的结合而实现的。为了促进化学成像中先进数据分析的使用和进一步发展，该项目开发的软件作为社区资源免费分发和推广，沿着说明其使用和应用的在线练习。西姆斯和XPS广泛应用于许多领域，因此提高这些技术和相关技术的性能对整个社会具有重大的长期效益。

项目成果

Femtosecond laser desorption ionization mass spectrometry imaging and multivariate analysis of lipids in pancreatic tissue

胰腺组织脂质的飞秒激光解吸电离质谱成像及多变量分析

• DOI: 10.1116/1.5016301
• 发表时间: 2018
• 期刊: Biointerphases
• 影响因子: 2.1
• 作者: Walker, Amy V.;Gelb, Lev D.;Barry, Grant E.;Subanajouy, Polatip;Poudel, Ananta;Hara, Manami;Veryovkin, Igor V.;Bell, Graeme I.;Hanley, Luke
• 通讯作者: Hanley, Luke

Toward understanding weak matrix effects in TOF SIMS

• DOI: 10.1116/1.5019682
• 发表时间: 2018-05-01
• 期刊: JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B
• 影响因子: 1.4
• 作者: Gelb, Lev D.;Walker, Amy V.
• 通讯作者: Walker, Amy V.