Assessing the physiological roles of ubiquitination in regulating neuronal ion channels, receptors and transporters

评估泛素化在调节神经元离子通道、受体和转运蛋白中的生理作用

• 批准号: DP0880571
• 负责人: Prof Philip Poronnik
• 金额: $ 37.48万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0880571
• 关键词: Assessing; physiological; roles; ubiquitination; regulating

Significant alterations in the activity neuronal transporters and receptors occur during tissue injury and regeneration as well as in many neurodegenerative disease states. Modulation of the pathways that control these transporters is an emerging therapeutic target, however, the molecular basis of these control mechanisms remain poorly understood. The outcome of this project will be a thorough characterisation of a novel regulatory paradigm in neurons that is likely to be crucial for neuronal development and regeneration, and will potentially provide novel therapeutic targets for various neuronal diseases.

在组织损伤和再生期间以及在许多神经退行性疾病状态中，神经元转运蛋白和受体的活性发生显著改变。调节控制这些转运蛋白的途径是一个新兴的治疗目标，然而，这些控制机制的分子基础仍然知之甚少。该项目的成果将是对神经元中一种新的调控模式的彻底表征，这种模式可能对神经元的发育和再生至关重要，并可能为各种神经元疾病提供新的治疗靶点。