Collaborative Research: Modeling and Computation of Three-Dimensional Multicomponent Vesicles in Complex Flow Domains

合作研究:复杂流域中三维多组分囊泡的建模与计算

基本信息

  • 批准号:
    1720420
  • 负责人:
  • 金额:
    $ 20.6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-01 至 2021-08-31
  • 项目状态:
    已结题

项目摘要

Vesicles have long been considered as model systems for studying fundamental physics underlying complicated biological systems such as cells and microcapsules. Additionally, vesicles are increasingly being used as carriers for drug delivery or as biochemical micro-reactors operating in physiological environments. This project aims to develop efficient computational models and numerical tools for modeling of vesicle dynamics, which involves phase separation, formation of compartments, and interactions among vesicles and their aqueous environment. The results are expected to aid in the design of phase domains on the surface of a vesicle such that specific proteins can anchor on the membrane to initiate subsequent biological reactions. The project aims to contribute to the forefront of research on constructing artificial cells with multiple compartments. The research also advances numerical method development, analytical theory, and integral equation formulations in the context of bio-membrane mechanics and particulate flows. The project will create opportunities for students to receive interdisciplinary training crossing the mathematical, biological, and physical sciences.This project addresses the challenges of mathematically modeling and numerically simulating three-dimensional multi-component and multi-compartment vesicles in complex flow domains using sharp interface methods. At the continuum level, the mathematical description of vesicle dynamics is a highly nonlinear, nonlocal moving boundary problem where the bilayer membrane serves as the moving boundary. The fundamental mathematical feature is that this system effectively couples surface phase dynamics, morphological evolution and compartment formation, and fluid motion so that the model describes a more realistic physical system than has been developed previously in the literature. The investigators develop and apply state-of-the-art adaptive numerical methods, perform analytical, numerical and modeling studies of important constituent processes, and work with experimentalists to test the model predictions and to help elucidate the underlying physical processes. The project will investigate how the presence of surface phases and multiple compartments modifies the classical motions and hydrodynamic interactions and may lead to novel dynamical regimes. The project will also investigate the morphological stability of multi-compartment vesicles in applied flows, and possible control strategies using multiple surface phases for optimizing stability in complex flow domains.
长期以来,囊泡一直被认为是研究细胞和微胶囊等复杂生物系统基础物理的模型系统。 此外,囊泡越来越多地被用作药物递送的载体或在生理环境中操作的生化微反应器。 该项目旨在开发有效的计算模型和数值工具,用于模拟囊泡动力学,其中涉及相分离,隔室的形成以及囊泡与其水环境之间的相互作用。 预计这些结果将有助于设计囊泡表面的相域,以便特定蛋白质可以锚在膜上以启动后续的生物反应。 该项目旨在为构建具有多个隔室的人工细胞的研究前沿做出贡献。该研究还推进了生物膜力学和颗粒流背景下的数值方法开发,分析理论和积分方程制剂。该项目将为学生创造机会,接受跨学科的培训,跨越数学,生物和物理科学。该项目解决了数学建模和数值模拟的挑战,三维多组分和多隔室囊泡在复杂的流动域使用尖锐的界面方法。在连续介质水平上,囊泡动力学的数学描述是一个高度非线性、非局部的移动边界问题,其中双层膜作为移动边界。基本的数学特征是,该系统有效地耦合表面相动力学,形态演变和车厢的形成,和流体运动,使该模型描述了一个更现实的物理系统比以前在文献中已经开发。研究人员开发和应用最先进的自适应数值方法,对重要的组成过程进行分析,数值和建模研究,并与实验人员合作测试模型预测,并帮助阐明潜在的物理过程。该项目将研究表面相和多个隔间的存在如何修改经典运动和流体动力学相互作用,并可能导致新的动力学机制。该项目还将研究应用流中多室囊泡的形态稳定性,以及使用多个表面相优化复杂流域稳定性的可能控制策略。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Pattern formation of the three-layer Saffman-Taylor problem in a radial Hele-Shaw cell
  • DOI:
    10.1103/physrevfluids.5.124005
  • 发表时间:
    2020-06
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Meng Zhao;Pedro H. A. Anjos;J. Lowengrub;Shuwang Li
  • 通讯作者:
    Meng Zhao;Pedro H. A. Anjos;J. Lowengrub;Shuwang Li
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Shuwang Li其他文献

Weakly nonlinear analysis of the Saffman-Taylor problem in a radially spreading fluid annulus
径向扩散流体环中 Saffman-Taylor 问题的弱非线性分析
  • DOI:
    10.1103/physrevfluids.5.054002
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Pedro H. A. Anjos;Shuwang Li
  • 通讯作者:
    Shuwang Li
Enhancing pavement structural resilience: analyzing the impact of vehicle-induced dynamic loads on RAP-recycled cement-stabilized crushed stone pavements with tip cracks
  • DOI:
    10.1617/s11527-024-02439-2
  • 发表时间:
    2024-08-13
  • 期刊:
  • 影响因子:
    3.900
  • 作者:
    Tengfei Nian;Maomin Wang;Shuwang Li;Piyi Li;Jiaqi Song
  • 通讯作者:
    Jiaqi Song
Search for e+ e- → Λ0bΛ0b near threshold
在阈值附近搜索 e+ e- → Λ0bΛ0b
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    D. Besson;T. Pedlar;D. Cronin;K. Gao;D. Gong;Y. Kubota;B. Lang;Shuwang Li;R. Poling;A. Scott;A. Smith;C. Stepaniak;S. Dobbs;Z. Metreveli;K. Seth;A. Tomaradze;P. Zweber;J. Ernst;A. Mahmood;K. Arms;K. Gan;H. Severini;D. Asner;S. Dytman;W. Love;S. Mehrabyan;J. Mueller;V. Savinov;Zheng Li;Alan D. Lopez;H. Mendez;J. Ramirez;G. Huang;D. Miller;V. Pavlunin;B. Sanghi;E. Shibata;I. Shipsey;G. Adams;M. Chassé;M. Cravey;J. Cummings;I. Dankó;J. Napolitano;Chawon Park;W. Park;J. Thayer;E. Thorndike;T. Coan;Y. Gao;F. Liu;R. Stroynowski;M. Artuso;C. Boulahouache;S. Blusk;J. Butt;E. Dambasuren;O. Dorjkhaidav;J. Li;N. Menaa
  • 通讯作者:
    N. Menaa
A Deterministic Mechanism for Side-branching in Dendritic Growth
树突生长中侧枝的确定性机制
  • DOI:
    10.3970/fdmp.2008.004.027
  • 发表时间:
    2008
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shuwang Li;Xiangrong Li;J. Lowengrub;M. Glicksman
  • 通讯作者:
    M. Glicksman
Search for the Lepton-Flavor-Violating Leptonic B 0 →μ ± τ ∓ and B 0 →e ± τ ∓
搜索违反轻子味的轻子 B 0 →μ ± τ ∓ 和 B 0 →e ± τ ∓
  • DOI:
    10.1103/physrevlett.93.241802
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    8.6
  • 作者:
    Adi Bornheim;E. Lipeles;S. Pappas;A. Weinstein;R. Briere;G. Chen;T. Ferguson;G. Tatishvili;H. Vogel;M. E. Watkins;N. Adam;J. Alexander;K. Berkelman;D. Cassel;J. Duboscq;K. Ecklund;R. Ehrlich;L. Fields;R. Galik;L. Gibbons;B. Gittelman;R. Gray;S. Gray;D. Hartill;B. Heltsley;D. Hertz;L. Hsu;C. Jones;J. Kandaswamy;D. Kreinick;V. Kuznetsov;H. Mahlke;T. O. Meyer;P. Onyisi;J. Patterson;D. Peterson;J. Pivarski;D. Riley;J. Rosner;A. Ryd;A. Sadoff;H. Schwarthoff;M. Shepherd;W. Sun;J. Thayer;D. Urner;T. Wilksen;M. Weinberger;S. Athar;P. Avery;L. Breva;R. Patel;V. Potlia;H. Stoeck;J. Yelton;P. Rubin;C. Cawlfield;B. Eisenstein;G. Gollin;I. Karliner;Doseok Kim;N. Lowrey;P. Naik;C. Sedlack;M. Selen;J. Thaler;Justin Williams;J. Wiss;K. W. Edwards;D. Besson;K. Gao;D. Gong;Y. Kubota;Shuwang Li;R. Poling;A. Scott;A. Smith;C. Stepaniak;J. Urheim;Z. Metreveli;K. Seth;A. Tomaradze;P. Zweber;J. Ernst;K. Arms;K. Gan;H. Severini;P. Skubic;D. Asner;S. Dytman;S. Mehrabyan;J. Mueller;V. Savinov;Z. Li;A. Lopez;H. Mendez;J. Ramirez;G. Huang;D. Miller;V. Pavlunin;B. Sanghi;E. Shibata;I. Shipsey;G. Adams;M. Chassé;J. Cummings;I. Dankó;J. Napolitano;D. Cronin;C. S. Park;W. Park;J. Thayer;E. Thorndike;T. Coan;Y. Gao;F. Liu;R. Stroynowski;M. Artuso;C. Boulahouache;S. Blusk;J. Butt;E. Dambasuren;O. Dorjkhaidav;N. Menaa;R. Mountain;H. Muramatsu;R. Nandakumar;R. Redjimi;R. Sia;T. Skwarnicki;S. Stone;J. Wang;Kevin Zhang;A. Mahmood;S. Csorna;G. Bonvicini;D. Cinabro;M. Dubrovin
  • 通讯作者:
    M. Dubrovin

Shuwang Li的其他文献

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{{ truncateString('Shuwang Li', 18)}}的其他基金

Collaborative Research: : Mathematical modeling and computation of morphological instabilities in reactive fluids driven out of equilibrium
合作研究::失去平衡的反应流体形态不稳定性的数学建模和计算
  • 批准号:
    2309798
  • 财政年份:
    2023
  • 资助金额:
    $ 20.6万
  • 项目类别:
    Standard Grant
Collaborative Research: Computationally Efficient Solvers for Power System Simulation
协作研究:用于电力系统仿真的计算高效求解器
  • 批准号:
    1307625
  • 财政年份:
    2013
  • 资助金额:
    $ 20.6万
  • 项目类别:
    Standard Grant
Collaborative Research: Reactive instabilities, colloids, and interfacial flows: experiments, modeling and numerics
合作研究:反应不稳定性、胶体和界面流动:实验、建模和数值
  • 批准号:
    1217277
  • 财政年份:
    2012
  • 资助金额:
    $ 20.6万
  • 项目类别:
    Standard Grant
Collaborative Research: Computational and theoretical approaches for the morphological control of material microstructures
合作研究:材料微观结构形态控制的计算和理论方法
  • 批准号:
    0914923
  • 财政年份:
    2009
  • 资助金额:
    $ 20.6万
  • 项目类别:
    Standard Grant

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