CREST Center for Complex Materials Design for Multidimensional Additive Processing (CoManD)

CREST 多维增材加工复杂材料设计中心 (CoManD)

• 批准号: 1735968
• 负责人: Subramanian Ramakrishnan
• 金额: $ 499.94万
• 依托单位: Florida Agricultural and Mechanical University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1735968&HistoricalAwards=false
• 关键词: CREST; Center; Complex; Materials; Design

The Centers of Research Excellence in Science and Technology (CREST) program supports the enhancement of research capabilities of minority-serving institutions through the establishment of centers that effectively integrate education and research. CREST promotes the development of new knowledge, enhancements of the research productivity of individual faculty, and an expanded presence of students historically underrepresented in science, technology, engineering, and mathematics disciplines. With CREST program support, Florida Agricultural and Mechanical University will establish the Center for Complex Materials Design for Multidimensional Additive Processing. The Center will promote advancements in the manufacture of novel combined materials in the micrometer scale for applications in magnetic shielding, energy and bio-medical technology. The ability to pattern multiple materials, on micrometer length scales, in three dimensions is critical for several technological applications including composites, microfluidics, photonics, and tissue engineering. The Center will be comprised of an interdisciplinary team of faculty from Chemical and Biomedical Engineering, Industrial Engineering, Biological and Agricultural Systems Engineering, Chemistry, Pharmaceutical Sciences and Physics.Simulations coupled with experiments will result in a molecular level understanding of the forces governing self-assembly in different materials. Printing of three dimensional tumor cell cultures on a chip using appropriate hydrogels will allow evaluation of the cytotoxicity of anticancer drugs and nanoparticles. Enhanced cell efficiency of printed photovoltaic cells will impact applications in portable electronics and power generation in automotive and space applications. The combined effect of flow and magnetic field induced orientation of novel nanoparticles will result in lightweight materials with enhanced dielectric properties for shielding and sensing applications.Undergraduate courses based on fundamentals of self-assembly, nanoparticle synthesis and characterization, additive manufacturing, nanomaterials in biology, and nanoparticles in medicine will be developed and offered to Florida Agricultural and Mechanical University students. A laboratory course in materials will be offered to graduate and undergraduate students involved in materials research. The Center will produce 15 Ph.Ds., directly impact 40 undergraduates and influence 100 graduate students and 300 undergraduates through collaborations and coursework.

科学和技术卓越研究中心(CREST)计划通过建立有效整合教育和研究的中心，支持加强少数群体服务机构的研究能力。CREST促进了新知识的发展，提高了个别教师的研究效率，并扩大了在科学、技术、工程和数学学科中历来代表性不足的学生的存在。在CREST项目的支持下，佛罗里达农业和机械大学将建立多维添加剂加工复合材料设计中心。该中心将促进微米级新型组合材料制造的进步，用于磁屏蔽、能源和生物医疗技术。在微米长的三维尺度上对多种材料进行图案制作的能力对于包括复合材料、微流体、光子学和组织工程在内的多种技术应用是至关重要的。该中心将由来自化学和生物医学工程、工业工程、生物和农业系统工程、化学、制药科学和物理学的教师组成一个跨学科的团队。模拟和实验将导致对不同材料中自我组装的力量的分子水平的理解。使用适当的水凝胶在芯片上打印三维肿瘤细胞培养物将允许评估抗癌药物和纳米颗粒的细胞毒性。印刷光伏电池电池效率的提高将影响便携式电子产品的应用，以及汽车和空间应用中的发电。新型纳米粒子的流动和磁场诱导取向的综合效应将产生具有增强的介电性能的轻质材料，用于屏蔽和传感应用。基于自组装、纳米粒子合成和表征、添加剂制造、生物纳米材料和医学纳米粒子的基础知识的本科生课程将被开发并提供给佛罗里达农业和机械大学的学生。将为从事材料研究的研究生和本科生开设材料实验室课程。该中心将培养15名博士，直接影响40名本科生，通过合作和课程安排影响100名研究生和300名本科生。

项目成果

Whole-Eye Perfusion Model for Screening of the Ocular Formulations via Confocal Laser Scanning Microscopy.

• DOI: 10.1208/s12249-019-1493-x
• 发表时间: 2019-09-12
• 期刊: AAPS PharmSciTech
• 影响因子: 3.3
• 作者: Kutlehria S;Bagde A;Patel N;Singh M
• 通讯作者: Singh M

Role of nano-lipid formulation of CARP-1 mimetic, CFM-4.17 to improve systemic exposure and response in osimertinib resistant non-small cell lung cancer.

Carp-1 Mimetic，CFM-4.17的纳米脂质制剂在埃米默替尼耐药的非小细胞肺癌中的全身暴露和反应的作用。

• DOI: 10.1016/j.ejpb.2020.11.007
• 发表时间: 2021-01
• 期刊: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
• 作者: Kommineni N;Nottingham E;Bagde A;Patel N;Rishi AK;Dev SRS;Singh M
• 通讯作者: Singh M

Cytotoxic and chemosensitizing effects of glycoalkaloidic extract on 2D and 3D models using RT4 and patient derived xenografts bladder cancer cells.

使用 RT4 和患者来源的异种移植膀胱癌细胞的 2D 和 3D 模型中配糖生物碱提取物的细胞毒性和化学增敏作用。

• DOI: 10.1016/j.msec.2020.111460
• 发表时间: 2021-03
• 期刊: Materials science & engineering. C, Materials for biological applications
• 作者: Miranda MA;Marcato PD;Mondal A;Chowdhury N;Gebeyehu A;Surapaneni SK;Bentley MVLB;Amaral R;Pan CX;Singh M
• 通讯作者: Singh M

Modeling Dynamic Swelling of Polymer-Based Artificial Muscles

聚合物人造肌肉的动态膨胀建模

• 发表时间: 2022
• 期刊: Soft matter
• 影响因子: 3.4
• 作者: Bowen, S. D.;*Hallinan, D.
• 通讯作者: *Hallinan, D.

Absorbent-Adsorbates: Amphiphilic Janus Microgels as Droplet Stabilizers

吸收剂-吸附剂：两亲性 Janus 微凝胶作为液滴稳定剂

• 发表时间: 2020
• 期刊: ACS applied materials interfaces
• 作者: Haney, B.