MRI: Acquisition of a 3D printer for Additive Manufacturing of Functional Materials for Biological Applications
MRI:采购一台 3D 打印机,用于生物应用功能材料的增材制造
基本信息
- 批准号:1726035
- 负责人:
- 金额:$ 19.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2019-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This Major Research Instrumentation (MRI) grant will enable the acquisition of a 3D printer for additive manufacturing of functional materials for biological applications. The PIs at Florida A&M University (FAMU) are exploring processes, structures and performance measures of novel engineered materials that will lead to significant achievements in material processing that have profound biological applications. This grant fills a gap in instrumentation at FAMU and enhances the current synergy across the PIs' research platform and offer unique solutions for different funded projects and thrust areas in the biological arena such as drug delivery, electrospinning, cancer therapy and scaffolds for bone tissue engineering. The project brings together researchers from chemical and biomedical engineering, pharmaceutical sciences, chemistry and industrial engineering and will play a key role in the education of undergraduate, graduate minority students and postdoctoral fellows across different disciplines. In particular, for the first time it will allow cross talk between the biological scientists and engineers thus resulting in development of novel fundamental science and devices that will play a key role in biomedical sciences. Introduction of materials education with the help of acquired printer and proposed research in the curriculum at different departments will provide a means to motivate minority students, retain them and enhance their scientific capability thus producing a pool of well-trained scientists. This Major Research Instrumentation (MRI) grant will support acquisition of a state-of-the-art 3D printer with unique capabilities of multi-material printing and the ability to pattern these multiple materials in three dimensions. Research component involves a) development of a novel bioprinting platform to print co-cultures using cancer cells and tumor associated fibroblasts which can simulate the human stromal characteristics b) integration of electrospinning and 3D printing to develop hierarchically structured scaffolds for tissue engineering c) 3D printed models for transdermal drug delivery of molecules like Testosterone and Estradiol and scaffolds for bone tissue engineering. 3D bio-printing of cancer cells shows significant promise for creating complex tissue and organ mimics and eliminates the gap between the in vitro drug screening and animal models. The requested nScrypt Biological Architectural Tool (BAT) system is a bio-printing platform with the ability to host up to four separate materials and print on curved surfaces or print 3D structures with a motion control accuracy of ±5 microns and repeatability up to ±2 microns in XY. The Smart pump included in the printer system has the ability to print a wide variety of biomaterials including living cells. The ability to control separate pumps/devices all under one software control and one platform provides a unique multilayer, multi-material and multi-structure capability which makes this printer ideal for the proposed projects.
这项重大研究仪器(MRI)拨款将使人们能够购买3D打印机,用于生物应用功能材料的增材制造。佛罗里达A M大学(FAMU)的PI正在探索新工程材料的工艺、结构和性能指标,这些材料将在具有深远生物学应用的材料加工方面取得重大成就。这笔赠款填补了FAMU仪器的空白,增强了PI研究平台的协同作用,并为生物竞技场的不同资助项目和推力领域提供了独特的解决方案,如药物输送,静电纺丝,癌症治疗和骨组织工程支架。该项目汇集了来自化学和生物医学工程,制药科学,化学和工业工程的研究人员,并将在不同学科的本科生,研究生少数民族学生和博士后研究员的教育中发挥关键作用。特别是,它将首次允许生物科学家和工程师之间的串扰,从而导致新的基础科学和设备的发展,这些科学和设备将在生物医学科学中发挥关键作用。在购置的打印机的帮助下引进材料教育,并在不同部门的课程中进行拟议的研究,这将提供一种手段来激励少数民族学生,留住他们,提高他们的科学能力,从而培养一批训练有素的科学家。这项重大研究仪器(MRI)拨款将支持购买最先进的3D打印机,该打印机具有独特的多材料打印能力,并能够在三维中对这些多种材料进行图案化。研究部分涉及a)开发一种新型生物打印平台,以使用癌细胞和肿瘤相关成纤维细胞打印共培养物,其可以模拟人类基质特征B)整合静电纺丝和3D打印,以开发用于组织工程的分层结构支架c)3D打印模型,用于透皮药物递送分子,如Tephthrin和Ephthrin以及骨组织工程支架。癌细胞的3D生物打印显示出创建复杂组织和器官模拟物的重大前景,并消除了体外药物筛选和动物模型之间的差距。申请的nScrypt生物结构工具(BAT)系统是一种生物打印平台,能够承载多达四种单独的材料,并在曲面上打印或打印3D结构,运动控制精度为±5微米,XY方向的可重复性高达±2微米。打印机系统中包含的智能泵能够打印各种生物材料,包括活细胞。在一个软件控制和一个平台下控制单独的泵/设备的能力提供了独特的多层,多材料和多结构能力,使该打印机成为拟议项目的理想选择。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Subramanian Ramakrishnan其他文献
Analysis of the Long Time Behavior of Enzymatic Cellulose Hydrolysis Kinetics
酶促纤维素水解动力学的长期行为分析
- DOI:
10.1515/ijcre-2017-0087 - 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
Subramanian Ramakrishnan;G. Brodeur;J. Telotte - 通讯作者:
J. Telotte
Non-Pharmaceutical Interventions as Controls to mitigate the spread of epidemics: An analysis using a spatiotemporal PDE model and math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="d1e642" altimg="si3.svg" class="math"mrowmiC/mimiO/mimiV/mimiI/mimiD/mi/mrow/math–19 data
- DOI:
10.1016/j.isatra.2021.02.038 - 发表时间:
2022-05-01 - 期刊:
- 影响因子:6.500
- 作者:
Faray Majid;Michael Gray;Aditya M. Deshpande;Subramanian Ramakrishnan;Manish Kumar;Shelley Ehrlich - 通讯作者:
Shelley Ehrlich
20 m s-resolved high-throughput X-ray photon correlation spectroscopy on a 500k pixel detector enabled by data-management workflow
通过数据管理工作流程实现 50 万像素探测器上的 20 m 分辨率高通量 X 射线光子相关光谱
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Qingteng Zhang;E. M. Dufresne;Y. Nakaye;P. Jemian;Takuto Sakumura;Yasutaka Sakuma;Joseph D. Ferrara;Piotr Maj;Asra Hassan;Divya Bahadur;Subramanian Ramakrishnan;F. Khan;S. Veseli;Alec R. Sandy;Nicholas Schwarz;S. Narayanan - 通讯作者:
S. Narayanan
A novel approach to forecasting reproduction numbers of spatiotemporal stochastic epidemic spread using a PDE-based model and real-time infection data
- DOI:
10.1038/s41598-025-91811-5 - 发表时间:
2025-03-21 - 期刊:
- 影响因子:3.900
- 作者:
Deepak Antony David;Chunyan Liu;Logan Street;Shelley Ehrlich;Manish Kumar;Subramanian Ramakrishnan - 通讯作者:
Subramanian Ramakrishnan
Subramanian Ramakrishnan的其他文献
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{{ truncateString('Subramanian Ramakrishnan', 18)}}的其他基金
Targeted Infusion Project: Enhancing Retention in the Chemical & Biomedical Engineering Program at Florida A and M University through Integrated Research, Teaching and Retention
靶向输注项目:增强化学品的保留
- 批准号:
2306449 - 财政年份:2023
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
HBCU-RISE: Enhancement of Research and Education Infrastructure in the Chemistry and Engineering of Multifunctional Materials
HBCU-RISE:加强多功能材料化学与工程领域的研究和教育基础设施
- 批准号:
2219558 - 财政年份:2022
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
Collaborative Research: Understanding Stochastic Spatiotemporal Dynamics of Epidemic Spread to Improve Control Interventions - From COVID-19 to Future Pandemics
合作研究:了解流行病传播的随机时空动态以改进控制干预措施 - 从 COVID-19 到未来的大流行
- 批准号:
2140405 - 财政年份:2022
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
CREST Center for Complex Materials Design for Multidimensional Additive Processing (CoManD)
CREST 多维增材加工复杂材料设计中心 (CoManD)
- 批准号:
1735968 - 财政年份:2017
- 资助金额:
$ 19.3万 - 项目类别:
Continuing Grant
Doctoral Dissertation Research: When Descriptive Representatives' Faces Don't Match Their Races: Inconsistent Attributes and Evaluations of Multiracial Officials
博士论文研究:当描述性代表的面孔与种族不匹配时:多种族官员的不一致属性和评价
- 批准号:
1647186 - 财政年份:2017
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
Building Social Science Data Infrastructure: The 2016 National Asian American Survey
建设社会科学数据基础设施:2016 年全国亚裔美国人调查
- 批准号:
1558986 - 财政年份:2016
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
Targeted Infusion Project: Enhancement of Materials Science Education through Active Learning at Florida A&M University
有针对性的注入项目:通过佛罗里达 A 的主动学习加强材料科学教育
- 批准号:
1623206 - 财政年份:2016
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
Research Initiation Award Grant - Colloidal Mixtures: Microstructure and Mechanics
研究启动奖 - 胶体混合物:微观结构和力学
- 批准号:
1238524 - 财政年份:2012
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: The Effect of Empathy on Public Opinion on Immigration
博士论文研究:同理心对移民舆论的影响
- 批准号:
1124608 - 财政年份:2011
- 资助金额:
$ 19.3万 - 项目类别:
Standard Grant
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