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2018 Protein Folding Dynamics: Order, Disorder, and Aggregation GRC in Galveston, TX

2018 年蛋白质折叠动力学：有序、无序和聚集 GRC，德克萨斯州加尔维斯顿

基本信息

批准号：
1743232
负责人：
Margaret Cheung
金额：
$ 1万
依托单位：
Gordon Research Conferences
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1743232&HistoricalAwards=false
关键词：
2018 Protein Folding Dynamics Order

项目摘要

The Gordon Research Conference (GRC) on Protein Folding Dynamics "Order, Disorder, and Aggregation" will be held at the Hotel Galvez in Galveston, Texas, January 7-12, 2018. A main purpose of this conference is to bring together experiment, theory, and simulation. Many of the key challenges in the field of protein folding dynamics can only be resolved in close collaboration between these disciplines, and this conference is an ideal forum for discussion between experts in experimental biophysics and experts in theory and computer simulation. This meeting will bring together senior scientists, postdoctoral researchers and graduate students from a wide range of interests and approaches to protein folding dynamics. The nature of the conference allows close interaction among participants, who can share their ideas and results unpublished and published, officially and off-the-record. By bringing together researchers from chemistry, physics and biology to explore recent exciting developments in this field in a concrete forum that encourages open discussions from researchers working on different systems, the new paradigm of cross-disciplinary research is strengthened. The program covers a range of topics, not restricted to, in vitro and in vivo folding, protein aggregation, and cellular phase separation mediated by proteins. The program creates a "Power Hour" platform for senior investigators to mentor graduate students and postdoctoral students on career development in round table discussions and will encourage partnerships between early career and established scientists and cross-pollinates new ideas in research. Particular care will be taken for the inclusion of diversity in ethnicity, gender and age, disability, and geographical location. The areas covered range from rapid and elementary processes, such as the early stages of folding and the behavior of unfolded proteins to much slower processes involving large molecular machinery, such as folding on the ribosome, and even reaching mesoscopic processes, including protein aggregation, and cellular phase transitions and regulatory processes. For the first time, the 2018 conference is expanding to include complete formal sessions on protein folding, unfolding, and aggregation, and liquid-liquid phase separation mediated by proteins and nucleic acids within a cell.

关于蛋白质折叠动力学“有序、无序和聚集”的戈登研究会议（GRC）将于2018年1月7日至12日在德克萨斯州加尔维斯顿的加尔维斯酒店举行。这次会议的一个主要目的是把实验、理论和模拟结合起来。蛋白质折叠动力学领域的许多关键挑战只能在这些学科之间的密切合作中解决，本次会议是实验生物物理学专家与理论和计算机模拟专家之间讨论的理想论坛。本次会议将汇集资深科学家、博士后研究人员和研究生，他们来自蛋白质折叠动力学的广泛兴趣和方法。会议的性质允许参与者之间的密切互动，他们可以分享他们的想法和结果，无论是未发表的还是已发表的，无论是正式的还是非正式的。通过将来自化学、物理和生物学的研究人员聚集在一起，在一个具体的论坛上探索该领域最近令人兴奋的发展，鼓励研究不同系统的研究人员进行公开讨论，加强了跨学科研究的新范式。该计划涵盖了一系列主题，不限于体外和体内折叠，蛋白质聚集和由蛋白质介导的细胞相分离。该项目为高级研究人员创建了一个“Power Hour”平台，在圆桌讨论中指导研究生和博士后的职业发展，并鼓励早期职业科学家和成熟科学家之间的合作伙伴关系，并在研究中交流新的想法。将特别注意纳入种族、性别和年龄、残疾和地理位置的多样性。涵盖的领域从快速和基本的过程，如折叠的早期阶段和未折叠蛋白质的行为，到涉及大分子机制的更慢的过程，如核糖体上的折叠，甚至达到介观过程，包括蛋白质聚集，细胞相变和调节过程。2018年的会议首次扩大到包括关于蛋白质折叠、展开和聚集以及细胞内蛋白质和核酸介导的液-液相分离的完整正式会议。