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Variant effect mapping through protein folding and stability

Variant effect mapping through protein folding and stability
通过蛋白质折叠和稳定性进行变异效应图谱
批准号：
486537
负责人：
Bestavros Samantha
金额：
$1.27万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-12-01 至 2023-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=486537&lang=en
关键词：
Allelic Variants Cancer Risk Disease Risk Nthl1 Nthl1 Tumour Syndrome Protein Barcoding Protein Misfolding Propensity Protein Thermal Stability Thermal Shift Assay Variant Effect Maps

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When individuals are born with or develop genetic mutations, otherwise known as allelic variants, the protein that is produced from their DNA may suffer a change in function that could potentially have detrimental effects on the individual. Many cancers a
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