Change of Neural Network Indicators through Narrative Treatment of PTSD in Torture Victims

酷刑受害者创伤后应激障碍 (PTSD) 叙事治疗中神经网络指标的变化

• 批准号: 23118087
• 负责人: Professor Dr. Frank Neuner
• 金额: --
• 依托单位: Arbeitseinheit 11 - Klinische Psychologie und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/23118087?language=en
• 关键词: Change; Neural; Network; Indicators; through

Current theories of posttraumatic stress disorder (PTSD) explain the symptoms of this disorder on the basis of pathological memory representations of the traumatic event. According to these theories there are two different pathological representations of the traumatic event. The fear structure is an associative neural network connecting the sensory, emotional and physical features of the traumatic situation. On the other hand there is a disorganized and incomprehensive representation of the traumatic event in autobiographical memory. Posttraumatic intrusions result from an uncontrolled activity of the fear structure when a person is reminded of the event. The lack of adequate temporal and spatial context information caused by the fragmented autobiographical representation prevents a cortical regulation and inhibition of the fear structure. Treatment of PTSD generally involves talking about the traumatic event in detail. It is unclear whether this process acts upon the fear structure or on autobiographical memory. The goal of the project is to test the hypothesis that treatment-facilitated recovery does not change the original fear structure but establishes an inhibitory mechanism that depends on verbal activity. An affective visual steady-state paradigm in magnetencephalography (MEG) using positive, aversive and neutral picture stimuli will be used to examine the spatial and temporal pattern of the processing of emotional stimuli. To examine the effects of treatment this paradigm will be used as outcome measure within a randomized controlled trial of Narrative Exposure Therapy and a waitinglist control condition for severely traumatized torture victims.

目前的创伤后应激障碍（PTSD）理论解释这种疾病的症状的基础上病理记忆表征的创伤事件。根据这些理论，创伤事件有两种不同的病理表现。恐惧结构是一个关联神经网络，连接创伤情境的感官、情感和身体特征。另一方面，在自传体记忆中，创伤事件的表征是混乱的和不全面的。创伤后侵入是由于当一个人被提醒事件时，恐惧结构的不受控制的活动。由于缺乏足够的时间和空间的背景信息所造成的碎片自传表征阻止了皮层的调节和抑制的恐惧结构。PTSD的治疗通常包括详细谈论创伤事件。目前还不清楚这一过程是作用于恐惧结构还是作用于自传体记忆。该项目的目标是测试这一假设，即治疗促进恢复不会改变原始的恐惧结构，但建立了一个依赖于言语活动的抑制机制。在脑磁图（MEG）中使用积极的，厌恶的和中性的图片刺激的情感视觉稳态范式将被用来检查情绪刺激的处理的空间和时间模式。为了检查治疗的效果，这种模式将被用来作为一个随机对照试验的叙事暴露疗法和严重创伤的酷刑受害者的候补名单控制条件的结果措施。