Entwicklung primordialer Keimzellen in Xenopus

非洲爪蟾原始生殖细胞的发育

• 批准号: 23221234
• 负责人: Professor Dr. Tomas Pieler
• 金额: --
• 依托单位: Zentrum Biochemie und Molekulare Zellbiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/23221234?language=en
• 关键词: Entwicklung; primordialer; Keimzellen; Xenopus

A primary cell asymmetry, as defined by the animal-vegetal axis in Xenopus oocytes, defines the molecular basis for germ cell specification during early embryogenesis. A small number of maternal mRNAs has previously been reported to be specifically associated with the germ plasm at the vegetal pole of Xenopus oocytes. A general screen for vegetally localizing maternal mRNAs, that we have performed, has resulted in the identification of more than 50 novel vegetal mRNAs, a major portion of these being associated with the germ plasm. The primary aim of this proposal is to analyze the function of the proteins encoded by such maternal, vegetally localizing mRNAs in the context of germ cell specification and migration in Xenopus.

非洲爪蟾卵母细胞中的动物-植物轴所定义的初级细胞不对称性，定义了早期胚胎发生期间生殖细胞规格的分子基础。少数母体mRNA先前已被报道与非洲爪蟾卵母细胞植物极的种质特异性相关。我们已经进行的植物定位母体mRNA的一般筛选已经鉴定出50多种新的植物mRNA，其中大部分与种质相关。这项建议的主要目的是分析的功能，这种母亲，植物定位的基因编码的蛋白质在非洲爪蟾的生殖细胞规范和迁移的背景下。