Neural tuning of the reading system

阅读系统的神经调节

• 批准号: 1756403
• 负责人: Karen Emmorey
• 金额: $ 64.89万
• 依托单位: San Diego State University Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1756403&HistoricalAwards=false
• 关键词: Neural; tuning; reading; system

Reading is a skill that is critical for our social, educational, and political lives, and yet we know relatively little about how our brain becomes "tuned" to written words. Many theories propose that reading builds upon speech perception and that the quality of phonological representations -- that is, those related to how words sound -- plays a central role in how the brain responds to printed words. Skilled readers who are congenitally and profoundly deaf pose a challenge to these models because they do not have rich phonological representations of speech. This project investigates word reading processes in deaf and hearing adults who have similar reading abilities. Its main aim is to understand whether brain areas involved in reading are impacted by differences in phonological knowledge and auditory experience. Electroencephalography (EEG) and innovative statistical analyses will be used to determine how the timing of the brain's response to words is influenced by deafness and reading skill. Functional Magnetic Resonance Imaging (fMRI) will also be used to characterize how brain regions previously linked to word-reading respond for deaf and hearing readers. In addition, this project aims to promote the participation of deaf people in research by providing an environment that is accessible to them (e.g., "deaf friendly" labs) and training that facilitates academic advancement. The principal investigators (Drs. Karen Emmorey and Phillip Holcomb) are committed to improving opportunities for deaf students.This project contains six studies that use neural tuning paradigms to identify the stimulus-based and experience-based factors that shape the brain's response to orthographic stimuli. Two event-related potential (ERP) studies investigate the "fine tuning" of different neural responses (e.g., N/P170, N270) across several levels of representation (e.g., words, pseudowords, consonant strings, pseudo-letter strings). Using linear mixed effects (LME) analyses these experiments examine how individual variation in specific linguistic skills modulate these ERP components. Two fMRI studies parallel these ERP studies but capitalize on the strengths of fMRI paradigms to reveal functional and spatial organization within the reading circuit. A third ERP study tests the distinction proposed by the Bimodal Interactive Activation Model (BIAM) between the N400w and N400c ERP responses (exploiting differences between deaf and hearing participants with respect to implicit picture naming). The final study examines whether differences in visual peripheral attention between deaf and hearing individuals impact neural tuning to letters (using a visual crowding paradigm). By addressing basic science questions about the flexibility of the reading circuit, this project will provide foundational evidence for developing reading interventions and improving reading acquisition for both deaf and hearing people.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

阅读是一项对我们的社会、教育和政治生活至关重要的技能，然而我们对大脑是如何“调谐”到书面文字的知之甚少。许多理论认为，阅读建立在言语感知的基础上，而语音表征的质量——即与单词发音有关的质量——在大脑对印刷单词的反应中起着核心作用。天生和深度失聪的熟练读者对这些模型提出了挑战，因为他们没有丰富的语音表征。这个项目研究了具有相似阅读能力的聋人和听力正常的成年人的单词阅读过程。其主要目的是了解涉及阅读的大脑区域是否受到语音知识和听觉经验差异的影响。脑电图（EEG）和创新的统计分析将用于确定大脑对单词的反应时间如何受到耳聋和阅读技能的影响。功能性磁共振成像（fMRI）也将被用来描述先前与失聪和听力正常的读者阅读单词相关的大脑区域的反应。此外，该项目旨在通过为聋哑人提供无障碍的环境（例如，“聋哑人友好”实验室）和促进学术进步的培训，促进聋哑人参与研究。主要研究者(dr。凯伦·埃莫雷（Karen Emmorey）和菲利普·霍尔科姆（Phillip Holcomb）致力于改善聋哑学生的机会。该项目包含六项研究，使用神经调节范式来识别基于刺激和基于经验的因素，这些因素塑造了大脑对正字法刺激的反应。两项事件相关电位（ERP）研究调查了不同神经反应（例如，N/P170, N270）在多个表征水平（例如，单词，假词，辅音字符串，伪字母字符串）上的“微调”。使用线性混合效应（LME）分析这些实验，研究特定语言技能的个体差异如何调节这些ERP成分。两项功能磁共振成像研究与这些ERP研究平行，但利用功能磁共振成像范式的优势来揭示阅读回路中的功能和空间组织。第三个ERP研究测试了双峰交互激活模型（BIAM）提出的N400w和N400c ERP反应之间的区别（利用聋人和听力健全参与者在内隐图片命名方面的差异）。最后一项研究考察了聋人与健全人之间视觉周边注意的差异是否会影响对字母的神经调节（使用视觉拥挤范式）。通过解决有关阅读回路灵活性的基础科学问题，本项目将为制定阅读干预措施和改善聋人和正常人的阅读习得提供基础证据。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Sensitivity to orthographic vs. phonological constraints on word recognition: An ERP study with deaf and hearing readers.

• DOI: 10.1016/j.neuropsychologia.2022.108420
• 发表时间: 2022-12-15
• 期刊: NEUROPSYCHOLOGIA
• 影响因子: 2.6
• 作者: Lee, Brittany;Martinez, Priscilla M.;Midgley, Katherine J.;Holcomb, Phillip J.;Emmorey, Karen
• 通讯作者: Emmorey, Karen

An ERP investigation of orthographic precision in deaf and hearing readers.

• DOI: 10.1016/j.neuropsychologia.2020.107542
• 发表时间: 2020-09
• 期刊: Neuropsychologia
• 影响因子: 2.6
• 作者: Meade G;Grainger J;Midgley KJ;Holcomb PJ;Emmorey K
• 通讯作者: Emmorey K

A data-driven approach to the semantics of iconicity in American Sign Language and English

美国手语和英语中象似语义的数据驱动方法

• DOI: 10.1017/langcog.2019.52
• 发表时间: 2020
• 期刊: Language and Cognition
• 影响因子: 1.8
• 作者: THOMPSON, BILL;PERLMAN, MARCUS;LUPYAN, GARY;SEVCIKOVA SEHYR, ZED;EMMOREY, KAREN
• 通讯作者: EMMOREY, KAREN

Teaching & Learning Guide for: The neurocognitive basis of skilled reading in prelingually and profoundly deaf adults.

教学

• DOI: 10.1111/lnc3.12410
• 发表时间: 2021
• 期刊: Language and linguistics compass
• 影响因子: 2.5
• 作者: Emmorey,Karen;Lee,Brittany
• 通讯作者: Lee,Brittany