REU Site: Nature's machinery through the prism of physics, biology, chemistry and engineering

REU 网站：通过物理、生物、化学和工程学的棱镜观察自然的机器

• 批准号: 1757658
• 负责人: Hugo Sanabria
• 金额: $ 38.02万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1757658&HistoricalAwards=false
• 关键词: REU; Site; Nature; machinery; through

This REU Site award to Clemson University, located in Clemson, SC, will support the training of 10 students for 10 weeks during the summers of 2019-2021. Program participants work with faculty, postdocs, graduate students, and other undergraduates on collaborative research exploring biology through the prism of physics, biology, chemistry and engineering (e.g., computational and experimental approaches for molecular insights into amyloid aggregation, studies of how missense mutations affect protein-DNA binding affinity, and quantifying properties of active polymer networks and gels from cytoskeletal proteins). The focus is on cross-disciplinary training; while each participant has a specific project with their own mentor, participants are paired to work together within a larger collaboration. The program includes a biophysics boot-camp, seminar series, workshops on research tools and professional development, journal club, off-campus field trips, ethics training, and cohort-building activities. Participants regularly present their contributions to collaborators and hear about the research of their peers. Each participant presents a poster of their own work adjacent to their collaborator's poster at the final summer research symposium, writes their own research manuscript, and is encouraged to present their work at scientific conferences. Participants also engage in outreach activities throughout the summer. It is anticipated that a total of 30 students, primarily from schools with limited research opportunities and from underrepresented minority groups, will be trained in the program. The program is designed to give participants a sense of the mutual contributions that physical scientists can make to biology, and that biologists can make to the physical sciences. Students will learn how research is conducted, and many will present the results of their work at scientific conferences. A common web-based assessment tool used by all REU Site programs funded by the Division of Biological Infrastructure will be used to determine the effectiveness of the training program. Students will be tracked after the program to determine their career paths. Students will be asked to respond to an automatic email sent via the NSF reporting system. More information about the program is available by visiting www.clemson.edu/physics/biophysics-reu, or by contacting the PI (Dr. Joshua Alper at [e-mail]) or co-PI (Dr. Hugo Sanabria at [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个REU网站奖给克莱姆森大学，位于克莱姆森，SC，将支持10名学生在2019年至2021年的夏天10周的培训。计划参与者与教师，博士后，研究生和其他本科生合作研究，通过物理，生物学，化学和工程的棱镜探索生物学（例如，用于对淀粉样蛋白聚集的分子洞察的计算和实验方法，错义突变如何影响蛋白质-DNA结合亲和力的研究，以及来自细胞骨架蛋白的活性聚合物网络和凝胶的定量性质）。重点是跨学科的培训;虽然每个参与者都有自己的导师的特定项目，但参与者将在更大的合作中进行配对。该计划包括生物物理学训练营，系列研讨会，研究工具和专业发展研讨会，期刊俱乐部，校外实地考察，道德培训和队列建设活动。参与者定期向合作者展示他们的贡献，并听取同行的研究。每个参与者在最后的夏季研究研讨会上展示自己工作的海报，并在合作者的海报旁边写自己的研究手稿，并鼓励他们在科学会议上展示自己的工作。参与者还在整个夏季参与外联活动。预计共有30名学生，主要来自研究机会有限的学校和代表性不足的少数群体，将在该方案中接受培训。该计划旨在让参与者了解物理科学家可以对生物学做出的共同贡献，以及生物学家可以对物理科学做出的贡献。学生将学习如何进行研究，许多人将在科学会议上展示他们的工作成果。由生物基础设施部资助的所有REU研究中心项目使用的通用网络评估工具将用于确定培训项目的有效性。学生将在课程结束后进行跟踪，以确定他们的职业道路。学生将被要求通过NSF报告系统自动发送电子邮件。有关该计划的更多信息，请访问www.clemson.edu/physics/bioprophics-reu，或联系PI（约书亚Alper博士，[e-mail]）或共同PI（Hugo Sanabria博士，[e-mail]）。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

项目成果

Quantitative Fluorescence Quenching by Aromatic Amino Acids

芳香氨基酸定量荧光猝灭

• DOI: 10.1016/j.bpj.2019.11.2618
• 发表时间: 2020
• 期刊: Biophysical Journal
• 影响因子: 3.4
• 作者: Latham, Danielle R.;Diaz, Arturo R.;Ribich, Jake;Saikia, Nabanita;Mulry, Emma;Casabianca, Leah;Ding, Feng;Sanabria, Hugo
• 通讯作者: Sanabria, Hugo