REU Site: Nature's machinery through the prism of physics, biology, chemistry and engineering

REU 网站：通过物理、生物、化学和工程学的棱镜观察自然的机器

• 批准号: 1757658
• 负责人: Hugo Sanabria
• 金额: $ 38.02万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-15 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1757658&HistoricalAwards=false
• 关键词: REU; Site; Nature; machinery; through

This REU Site award to Clemson University, located in Clemson, SC, will support the training of 10 students for 10 weeks during the summers of 2019-2021. Program participants work with faculty, postdocs, graduate students, and other undergraduates on collaborative research exploring biology through the prism of physics, biology, chemistry and engineering (e.g., computational and experimental approaches for molecular insights into amyloid aggregation, studies of how missense mutations affect protein-DNA binding affinity, and quantifying properties of active polymer networks and gels from cytoskeletal proteins). The focus is on cross-disciplinary training; while each participant has a specific project with their own mentor, participants are paired to work together within a larger collaboration. The program includes a biophysics boot-camp, seminar series, workshops on research tools and professional development, journal club, off-campus field trips, ethics training, and cohort-building activities. Participants regularly present their contributions to collaborators and hear about the research of their peers. Each participant presents a poster of their own work adjacent to their collaborator's poster at the final summer research symposium, writes their own research manuscript, and is encouraged to present their work at scientific conferences. Participants also engage in outreach activities throughout the summer. It is anticipated that a total of 30 students, primarily from schools with limited research opportunities and from underrepresented minority groups, will be trained in the program. The program is designed to give participants a sense of the mutual contributions that physical scientists can make to biology, and that biologists can make to the physical sciences. Students will learn how research is conducted, and many will present the results of their work at scientific conferences. A common web-based assessment tool used by all REU Site programs funded by the Division of Biological Infrastructure will be used to determine the effectiveness of the training program. Students will be tracked after the program to determine their career paths. Students will be asked to respond to an automatic email sent via the NSF reporting system. More information about the program is available by visiting www.clemson.edu/physics/biophysics-reu, or by contacting the PI (Dr. Joshua Alper at [e-mail]) or co-PI (Dr. Hugo Sanabria at [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

位于南卡罗来纳州克莱姆森市的克莱姆森大学的REU网站奖将在2019 - 2021年夏季支持10个学生的培训10周。计划参与者与教师，博士后，研究生和其他本科生合作，在协作研究上通过物理学，生物学，化学和工程学的棱镜探索生物学（例如，分子洞察的计算和实验方法，用于分子洞察到淀粉样蛋白酶汇总的分子洞察，从蛋白质）。重点是跨学科培训；尽管每个参与者都有一个与自己的导师的特定项目，但参与者可以在更大的合作中配对。该计划包括生物物理学引导训练营，研讨会系列，研究工具和专业发展的研讨会，期刊俱乐部，校外实地考察，道德培训和队列建设活动。参与者会定期向合作者介绍他们的贡献，并了解其同龄人的研究。每个参与者都在最后的夏季研究研讨会上介绍了与合作者海报相邻的自己的作品海报，写下了自己的研究手稿，并鼓励在科学会议上介绍他们的作品。参与者在整个夏季还从事外展活动。预计将在该计划中培训总共30名学生，主要来自研究机会有限的学校，来自代表性不足的少数群体。该计划旨在使参与者了解物理科学家可以对生物学做出的相互贡献，并且生物学家可以对物理科学做出。学生将学习如何进行研究，许多人会在科学会议上介绍他们的工作结果。由生物基础设施部资助的所有REU网站计划使用的常见基于Web的评估工具将用于确定培训计划的有效性。计划后将跟踪学生以确定自己的职业道路。将要求学生回复通过NSF报告系统发送的自动电子邮件。有关该计划的更多信息，可以通过访问www.clemson.edu/physics/biophysics-reu，或通过与PI联系（通过[e-mail]）或Co-pi（Joshua alper博士）或Co-pi（Hugo Sanabria博士（Hugo Sanabria博士）（通过[e-mail]）进行评估。优点和更广泛的影响审查标准。

项目成果

Quantitative Fluorescence Quenching by Aromatic Amino Acids

芳香氨基酸定量荧光猝灭

• DOI: 10.1016/j.bpj.2019.11.2618
• 发表时间: 2020
• 期刊: Biophysical Journal
• 影响因子: 3.4
• 作者: Latham, Danielle R.;Diaz, Arturo R.;Ribich, Jake;Saikia, Nabanita;Mulry, Emma;Casabianca, Leah;Ding, Feng;Sanabria, Hugo
• 通讯作者: Sanabria, Hugo