Bone regulation - cell interactions to disease

骨调节——细胞与疾病的相互作用

• 批准号: DP0879466
• 负责人: Prof Peter Pivonka
• 金额: $ 17.7万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0879466
• 关键词: Bone; regulation; cell; interactions; disease

Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their interaction with drugs is essential in order to develop new therapies and to effectively design novel biological compatible bone implants. This research proposal closely aligns with national research priority two, i.e., promoting and maintaining good health (ageing well, ageing productively).

许多骨疾病如骨质疏松症、佩吉特病和机会癌相关的骨疾病与骨细胞之间的通讯途径的破坏直接相关，导致骨重建的不平衡。虽然这些疾病是常见的，并造成相当大的痛苦，在大多数情况下，很少有人知道的机制负责功能失调的重塑。了解骨细胞之间的通讯网络及其与药物的相互作用对于开发新的治疗方法和有效设计新型生物相容性骨植入物至关重要。 这项研究提案与国家研究优先事项二密切相关，即，促进和保持良好的健康（良好的老龄化，老龄化的生产力）。