Numerical investigation of signal mechanotransduction of bone cells - application to bone remodeling

骨细胞信号机械转导的数值研究——在骨重塑中的应用

• 批准号: DP0559377
• 负责人: Prof Peter Pivonka
• 金额: $ 16.03万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-03-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0559377
• 关键词: Numerical; investigation; signal; mechanotransduction; bone

The understanding of signal mechanotransduction of bone cells is directly related to mechanical activation of bone remodeling processes, i.e., resorption and formation of bone tissue. Understanding of bone remodeling is essential for the development of new bone implants, the prognosis of osteosporosis, and studies related to changes in microgravity (e.g. space flight) to name a few key applications. This research proposal closely aligns with one of the major national research priorities, i.e., promoting and maintaining good health (ageing well, ageing productively). The research project is aimed to understand how mechanically induced loading may activate remodeling of bone.

对骨细胞信号转导机制的了解直接关系到骨组织的吸收和形成等骨重塑过程的机械激活。了解骨重建对于新骨植入物的开发、骨孢子病的预后以及与微重力变化(例如太空飞行)相关的研究等等关键应用都是至关重要的。这项研究建议与主要的国家研究优先事项之一密切一致，即促进和保持良好的健康(衰老良好，有成效地衰老)。该研究项目旨在了解机械诱导负荷如何激活骨重建。