Collaborative Research: Developing a Quantitative Three-Dimensional Understanding of Cardiac Arrhythmias
合作研究:对心律失常进行定量的三维理解
基本信息
- 批准号:1762553
- 负责人:
- 金额:$ 33.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project aims to develop a better understanding of what initiates some of the most lethal heart rhythms using mathematics and data assimilation methods used in weather forecasting. The detailed behavior of cardiac cells and tissue cannot be measured directly, especially inside of the heart muscle. This project will develop and validate new ways to estimate the behavior of the heart during abnormal rhythms. The knowledge gained will be used to identify ways that could be used to improve the effectiveness of treatments for these abnormal rhythms as delivered by electrical devices. The research efforts will also contribute to broadening participation of underrepresented groups and integration of research into both classroom teaching and informal education. The success of this project will directly contribute towards the progress of science to advance the national health. Many cardiac arrhythmias develop when the propagation of electrical waves through cardiac muscle, a process that triggers contraction, is disrupted. Despite the importance of understanding these arrhythmias and notwithstanding advances made through experimentation and computational modeling, many unanswered questions remain, especially regarding what happens in the typically unobserved thickness of cardiac tissue. This project will involve studying the role of tissue thickness on the development and progression of complicated spatiotemporal dynamics for certain types of arrhythmias such as tachycardia and fibrillation, when experiments often reveal little obvious correlation between surface observations. In particular, the detailed effects of potentially therapeutic electrical interventions will be analyzed. To accomplish these goals, data assimilation, a technique from weather forecasting, will be applied to recover high-resolution estimates of complex cardiac electrical states observed in experiments using spatiotemporally sparse observations of only one state variable. The response of the cardiac system when methods to control the dynamics are applied will be quantified. The resulting improved understanding of the heart's behavior and response to control attempts could lead to improved control methods that can restore normal behavior across the heart's thickness more reliably, more quickly, or with lower energies compared to standard methods.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这个项目旨在利用天气预报中使用的数学和数据同化方法,更好地理解是什么引发了一些最致命的心率节律。心肌细胞和组织的详细行为不能直接测量,特别是在心肌内。该项目将开发和验证新的方法来估计异常节律期间的心脏行为。所获得的知识将被用来确定可以用来提高对电子设备所传递的这些异常节律的治疗效果的方法。研究工作还将有助于扩大代表性不足群体的参与,并将研究纳入课堂教学和非正规教育。该项目的成功将直接促进科学进步,促进国民健康。当电波在心肌中的传播被中断时,许多心律失常就会发生,这是一个触发收缩的过程。尽管了解这些心律失常很重要,尽管通过实验和计算建模取得了进展,但仍有许多未回答的问题,特别是关于通常未观察到的心脏组织厚度发生了什么。这个项目将涉及研究组织厚度在某些类型的心律失常(如心动过速和纤颤)复杂时空动力学的发展和进展中的作用,而实验往往显示表面观察之间几乎没有明显的相关性。特别是,潜在治疗性电干预的详细影响将被分析。为了实现这些目标,天气预报中的一种技术--数据同化将被应用于恢复在实验中观察到的复杂心脏电状态的高分辨率估计,该估计只使用一个状态变量的时空稀疏观测。当应用控制动力学的方法时,心脏系统的反应将被量化。由此产生的对心脏行为和对控制尝试的响应的改进可能会导致改进的控制方法,与标准方法相比,可以更可靠、更快或以更低的能量恢复心脏厚度的正常行为。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(24)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cell Unexcitability and Electrotonic Coupling Phenomenon Analysis of Ablation-Created Lesions: A Study Case with Ablated Explanted Human Heart
消融造成的病变的细胞不兴奋性和电耦合现象分析:消融外植人心脏的研究案例
- DOI:10.22489/cinc.2022.405
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Gabriela Siles Paredes, "Jimena;Salinet, Joao;Crowley, Christopher;Fenton, Flavio;Bhatia, Neal;Uzelac", Ilija
- 通讯作者:Uzelac", Ilija
Prediction of chaotic time series using recurrent neural networks and reservoir computing techniques: A comparative study
- DOI:10.1016/j.mlwa.2022.100300
- 发表时间:2022-04
- 期刊:
- 影响因子:0
- 作者:S. Shahi;F. Fenton;E. Cherry
- 通讯作者:S. Shahi;F. Fenton;E. Cherry
Spiral wave breakup: Optical mapping in an explanted human heart shows the transition from ventricular tachycardia to ventricular fibrillation and self-termination
螺旋波分裂:外植人类心脏的光学测绘显示从室性心动过速到心室颤动和自我终止的转变
- DOI:10.1016/j.hrthm.2022.07.013
- 发表时间:2022
- 期刊:
- 影响因子:5.5
- 作者:Uzelac, Ilija;Iravanian, Shahriar;Bhatia, Neal K.;Fenton, Flavio H.
- 通讯作者:Fenton, Flavio H.
High-Resolution Optical Measurement of Cardiac Restitution, Contraction, and Fibrillation Dynamics in Beating vs. Blebbistatin-Uncoupled Isolated Rabbit Hearts
- DOI:10.3389/fphys.2020.00464
- 发表时间:2020-05-26
- 期刊:
- 影响因子:4
- 作者:Kappadan, Vineesh;Telele, Saba;Christoph, Jan
- 通讯作者:Christoph, Jan
Generation of Monophasic Action Potentials and Intermediate Forms
单相动作电位和中间形式的生成
- DOI:10.1016/j.bpj.2020.05.039
- 发表时间:2020
- 期刊:
- 影响因子:3.4
- 作者:Iravanian, Shahriar;Uzelac, Ilija;Herndon, Conner;Langberg, Jonathan J.;Fenton, Flavio H.
- 通讯作者:Fenton, Flavio H.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Flavio Fenton其他文献
IL-1β enhances susceptibility to atrial fibrillation in mice by acting through resident macrophages and promoting caspase-1 expression
白细胞介素-1β通过作用于驻留巨噬细胞并促进半胱天冬酶-1 表达来增强小鼠对心房颤动的易感性
- DOI:
10.1038/s44161-025-00610-8 - 发表时间:
2025-02-06 - 期刊:
- 影响因子:10.800
- 作者:
Oscar Moreno-Loaiza;Vinicius Cardoso Soares;Manuela de Assumpção Souza;Narendra Vera-Nuñez;Ainhoa Rodriguez de Yurre Guirao;Tatiana Pereira da Silva;Ana Beatriz Pozes;Larissa Perticarrari;Evelin Monteiro;Maria Clara Albino;Sophia Barros Silva;Suelen Silva Gomes Dias;Leonardo Maciel;Humberto Muzi-Filho;Dahienne Ferreira de Oliveira;Bruno Cabral Braga;Luan Pereira Diniz;Mario Costa Cruz;Simone Reis Barbosa;Archimedes Barbosa Castro-Junior;Luciana Conde;Mauro Jorge Cabral-Castro;Olga Ferreira de Souza;Martha Valéria Tavares Pinheiro;Nilson Araújo de Oliveira Junior;Leonardo Rezende de Siqueira;Rodrigo Periquito Cosenza;Claudio Munhoz da Fontoura;Jose Carlos Pizzolante Secco;Juliana da Rocha Ferreira;Andréa Silvestre de Sousa;Denilson Albuquerque;Ronir Raggio Luiz;Pedro Nicolau-Neto;Marco Antonio Pretti;Mariana Boroni;Martin Hernán Bonamino;Tais Hanae Kasai-Brunswick;Debora Bastos Mello;Triciana Gonçalves-Silva;Isalira Peroba Ramos;Fernando A. Bozza;João Paulo do Vale Madeiro;Roberto Coury Pedrosa;Marcela Sorelli Carneiro-Ramos;Herculano da Silva Martinho;Patrícia T. Bozza;Fernanda Mesquita de Souza;Gabriel Victor Lucena da Silva;Thiago M. Cunha;Ilija Uzelac;Flavio Fenton;Renata Moll-Bernardes;Claudia N. Paiva;Ariel L. Escobar;Emiliano Medei - 通讯作者:
Emiliano Medei
Flavio Fenton的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Flavio Fenton', 18)}}的其他基金
NSF/FDA SIR: Real-Time Simulations of Electrical Activity of the Heart and Augmented/Virtual Reality for Medical Device Applications
NSF/FDA SIR:心脏电活动的实时模拟以及医疗设备应用的增强/虚拟现实
- 批准号:
2037894 - 财政年份:2021
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
CPS: Frontier: Collaborative Research: Compositional, Approximate, and Quantitative Reasoning for Medical Cyber-Physical Systems
CPS:前沿:协作研究:医疗网络物理系统的组合、近似和定量推理
- 批准号:
1446675 - 财政年份:2015
- 资助金额:
$ 33.33万 - 项目类别:
Continuing Grant
Collaborative Research: Novel Data Assimilation Techniques in Mathematical Cardiology-Development, Analysis and Validation
合作研究:数学心脏病学中的新数据同化技术的开发、分析和验证
- 批准号:
1413037 - 财政年份:2014
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Development, verification, and validation of computer models of cardiac fibrillation
心脏颤动计算机模型的开发、验证和验证
- 批准号:
1347015 - 财政年份:2013
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: CDI Type II: Dynamics and Control of Cardiac Tissue
合作研究:CDI II 型:心脏组织的动力学和控制
- 批准号:
1341128 - 财政年份:2012
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: Intramural Forecasting of Cardiac Electrical Dynamics
合作研究:心脏电动力学的壁内预测
- 批准号:
1234332 - 财政年份:2012
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: Intramural Forecasting of Cardiac Electrical Dynamics
合作研究:心脏电动力学的壁内预测
- 批准号:
1341190 - 财政年份:2012
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: CDI Type II: Dynamics and Control of Cardiac Tissue
合作研究:CDI II 型:心脏组织的动力学和控制
- 批准号:
1028261 - 财政年份:2010
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Nonlinear Dynamics and Bifurcations in Cardiac Tissue
心脏组织的非线性动力学和分叉
- 批准号:
0800793 - 财政年份:2008
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
相似国自然基金
Research on Quantum Field Theory without a Lagrangian Description
- 批准号:24ZR1403900
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
Cell Research
- 批准号:31224802
- 批准年份:2012
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research
- 批准号:31024804
- 批准年份:2010
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research (细胞研究)
- 批准号:30824808
- 批准年份:2008
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Research on the Rapid Growth Mechanism of KDP Crystal
- 批准号:10774081
- 批准年份:2007
- 资助金额:45.0 万元
- 项目类别:面上项目
相似海外基金
Collaborative Research: GEO OSE Track 2: Developing CI-enabled collaborative workflows to integrate data for the SZ4D (Subduction Zones in Four Dimensions) community
协作研究:GEO OSE 轨道 2:开发支持 CI 的协作工作流程以集成 SZ4D(四维俯冲带)社区的数据
- 批准号:
2324714 - 财政年份:2024
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: GEO OSE Track 2: Developing CI-enabled collaborative workflows to integrate data for the SZ4D (Subduction Zones in Four Dimensions) community
协作研究:GEO OSE 轨道 2:开发支持 CI 的协作工作流程以集成 SZ4D(四维俯冲带)社区的数据
- 批准号:
2324709 - 财政年份:2024
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: GEO OSE Track 2: Developing CI-enabled collaborative workflows to integrate data for the SZ4D (Subduction Zones in Four Dimensions) community
协作研究:GEO OSE 轨道 2:开发支持 CI 的协作工作流程以集成 SZ4D(四维俯冲带)社区的数据
- 批准号:
2324713 - 财政年份:2024
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: GEO OSE Track 2: Developing CI-enabled collaborative workflows to integrate data for the SZ4D (Subduction Zones in Four Dimensions) community
协作研究:GEO OSE 轨道 2:开发支持 CI 的协作工作流程以集成 SZ4D(四维俯冲带)社区的数据
- 批准号:
2324710 - 财政年份:2024
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: GEO OSE Track 2: Developing CI-enabled collaborative workflows to integrate data for the SZ4D (Subduction Zones in Four Dimensions) community
协作研究:GEO OSE 轨道 2:开发支持 CI 的协作工作流程以集成 SZ4D(四维俯冲带)社区的数据
- 批准号:
2324711 - 财政年份:2024
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: GEO OSE Track 2: Developing CI-enabled collaborative workflows to integrate data for the SZ4D (Subduction Zones in Four Dimensions) community
协作研究:GEO OSE 轨道 2:开发支持 CI 的协作工作流程以集成 SZ4D(四维俯冲带)社区的数据
- 批准号:
2324712 - 财政年份:2024
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: Developing optimally customized-mode-selective photonic lanterns to enable the characterization of hundreds of exoplanets on solar system.
合作研究:开发最佳定制模式选择光子灯笼,以表征太阳系上数百颗系外行星。
- 批准号:
2308361 - 财政年份:2023
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative Research: Elements: ProDM: Developing A Unified Progressive Data Management Library for Exascale Computational Science
协作研究:要素:ProDM:为百亿亿次计算科学开发统一的渐进式数据管理库
- 批准号:
2311757 - 财政年份:2023
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant
Collaborative research: Developing cancer-specific targeting near-IR photosensitizers for in vitro theranostic photodynamic therapy and photothermal therapy
合作研究:开发用于体外治疗诊断光动力疗法和光热疗法的癌症特异性靶向近红外光敏剂
- 批准号:
2317606 - 财政年份:2023
- 资助金额:
$ 33.33万 - 项目类别:
Continuing Grant
Collaborative Research: DMREF: Developing and Harnessing the Platform of Quasi-One-Dimensional Topological Materials for Novel Functionalities and Devices
合作研究:DMREF:开发和利用用于新功能和器件的准一维拓扑材料平台
- 批准号:
2324033 - 财政年份:2023
- 资助金额:
$ 33.33万 - 项目类别:
Standard Grant