Collaborative Research: Developing a Quantitative Three-Dimensional Understanding of Cardiac Arrhythmias

合作研究：对心律失常进行定量的三维理解

• 批准号: 1762803
• 负责人: Elizabeth Cherry
• 金额: $ 23.5万
• 依托单位: Rochester Institute of Tech
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1762803&HistoricalAwards=false
• 关键词: Collaborative; Research; Developing; Quantitative; Three

This project aims to develop a better understanding of what initiates some of the most lethal heart rhythms using mathematics and data assimilation methods used in weather forecasting. The detailed behavior of cardiac cells and tissue cannot be measured directly, especially inside of the heart muscle. This project will develop and validate new ways to estimate the behavior of the heart during abnormal rhythms. The knowledge gained will be used to identify ways that could be used to improve the effectiveness of treatments for these abnormal rhythms as delivered by electrical devices. The research efforts will also contribute to broadening participation of underrepresented groups and integration of research into both classroom teaching and informal education. The success of this project will therefore directly contribute towards the progress of science to advance the national health. Many cardiac arrhythmias develop when the propagation of electrical waves through cardiac muscle, a process that triggers contraction, is disrupted. Despite the importance of understanding these arrhythmias and notwithstanding advances made through experimentation and computational modeling, many unanswered questions remain, especially regarding what happens in the typically unobserved thickness of cardiac tissue. This project will involve studying the role of tissue thickness on the development and progression of complicated spatiotemporal dynamics for certain types of arrhythmias such as tachycardia and fibrillation, when experiments often reveal little obvious correlation between surface observations. In particular, the detailed effects of potentially therapeutic electrical interventions will be analyzed. To accomplish these goals, data assimilation, a technique from weather forecasting, will be applied to recover high-resolution estimates of complex cardiac electrical states observed in experiments using spatiotemporally sparse observations of only one state variable. The response of the cardiac system when methods to control the dynamics are applied will be quantified. The resulting improved understanding of the heart's behavior and response to control attempts could lead to improved control methods that can restore normal behavior across the heart's thickness more reliably, more quickly, or with lower energies compared to standard methods.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目旨在利用天气预报中使用的数学和数据同化方法，更好地了解是什么引发了一些最致命的心律。心脏细胞和组织的详细行为无法直接测量，特别是在心肌内部。 该项目将开发和验证新的方法来估计异常节律期间心脏的行为。所获得的知识将用于确定可用于提高电气设备提供的这些异常节律治疗有效性的方法。研究工作还将有助于扩大代表性不足群体的参与，并将研究纳入课堂教学和非正规教育。因此，该项目的成功将直接促进科学进步，促进国民健康。许多心律失常是在电波通过心肌的传播（触发收缩的过程）被中断时发生的。尽管了解这些心律失常的重要性，尽管通过实验和计算建模取得了进展，但仍然存在许多未回答的问题，特别是关于心脏组织通常不可观察的厚度中发生了什么。该项目将涉及研究组织厚度对某些类型的心律失常（如心动过速和纤维性颤动）的复杂时空动力学的发展和进展的作用，而实验往往揭示表面观察之间几乎没有明显的相关性。特别是，潜在的治疗性电干预的详细影响将进行分析。为了实现这些目标，数据同化，天气预报的技术，将被应用于恢复高分辨率的估计复杂的心脏电状态的实验中观察到的时空稀疏观测只有一个状态变量。当应用控制动力学的方法时，心脏系统的响应将被量化。由此产生的对心脏行为和对控制尝试的反应的更好的理解可能导致改进的控制方法，与标准方法相比，该方法可以更可靠，更快或更低的能量恢复心脏厚度的正常行为。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

项目成果

Cell Fate Forecasting: A Data-Assimilation Approach to Predict Epithelial-Mesenchymal Transition

• DOI: 10.1016/j.bpj.2020.02.011
• 发表时间: 2019-06
• 期刊: Biophysical Journal
• 影响因子: 3.4
• 作者: Mario J. Mendez;M. Hoffman;E. Cherry;Christopher A. Lemmon;S. Weinberg

Robust data assimilation with noise: Applications to cardiac dynamics

• DOI: 10.1063/5.0033539
• 发表时间: 2021-01-01
• 期刊: CHAOS
• 影响因子: 2.9
• 作者: Marcotte, Christopher D.;Fenton, Flavio H.;Cherry, Elizabeth M.
• 通讯作者: Cherry, Elizabeth M.

Sensitivity of a data-assimilation system for reconstructing three-dimensional cardiac electrical dynamics

• DOI: 10.1098/rsta.2019.0388
• 发表时间: 2020-06-12
• 期刊: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
• 影响因子: 5
• 作者: Hoffman, Matthew J.;Cherry, Elizabeth M.
• 通讯作者: Cherry, Elizabeth M.