STTR Phase I: Directional minimally invasive microwave antenna for precise spatial control of thermal ablation

STTR 第一阶段：定向微创微波天线，用于热消融的精确空间控制

• 批准号: 1819177
• 负责人: Austin Pfannenstiel
• 金额: $ 22.5万
• 依托单位: Precision Microwave Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2019-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1819177&HistoricalAwards=false
• 关键词: STTR; Phase; Directional; minimally; invasive

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project include development of a commercial proof-of-concept percutaneous directional microwave ablation (MWA) applicator which may provide medical practitioners a new approach for treating cancer. In clinical use, a directional MWA applicator will facilitate both procedural and technical simplification of MWA treatments, saving time and critical resources in hospitals, and ultimately improve quality of, and access to, cancer treatment for a broad range of patients. The research and development proposed in this project will enhance scientific and technological understanding of miniaturized MWA antennas capable of radiating with directional patterns. Specifically, special materials to reduce required antenna dimension and increase efficiency, and advanced antenna designs to maximize the size of directional ablation zones will be studied during this project. Commercial development of the proposed technical advances could expand their use for the treatment of other medical conditions or for applications in other industries such as wireless communications. This STTR Phase I project will contribute to the creation of technology jobs in Kansas, a region where there are few medical or technology companies.This STTR Phase I project proposes to develop a commercial proof-of-concept directional microwave ablation (MWA) applicator. MWA procedures offer cost-effective, minimally-invasive treatment options for localized tumors and other disease. These treatments are especially important to the large population of cancer patients who are poor candidates for surgery or other physically demanding therapies. However, currently available MWA systems employ applicators with omni-directional radiation patterns, which if not placed precisely may damage critical healthy tissues or result in disease recurrence. A directional MWA applicator can facilitate technical and procedural simplifications which to alleviate these current challenges. We will investigate: (1) alternative materials to shrink antenna cross-section and (2) novel antenna geometries to maximize the size of directional microwave ablation zones. We will employ an approach integrating multiphysics computational models, benchtop experimentation in ex vivo tissue, and experiments in animal models in vivo to design, optimize, and validate our device. Our anticipated technical results are the development of a MWA applicator that provides directional control of radiation pattern that can ablate to depths of greater than 30 mm, creating an ablation volume comparable to current clinical non-directional devices.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小型企业技术转移（STTR）项目的更广泛的影响/商业潜力包括开发商业概念经皮的定向微波炉消融（MWA）施加器，该涂抹器可能会为医生提供一种治疗癌症的新方法。在临床用途中，定向MWA的涂抹器将促进MWA治疗的程序和技术简化，节省医院的时间和关键资源，并最终提高广泛患者的癌症治疗质量并获得癌症治疗。该项目提出的研究与发展将增强对能够用方向模式辐射的微型MWA天线的科学和技术理解。具体而言，在此项目期间，将研究特殊的材料，以降低所需的天线尺寸并提高效率，并提高天线设计以最大程度地提高方向消融区的大小。拟议技术进步的商业发展可能会扩大其用于治疗其他医疗状况或其他行业（例如无线通信）的应用。这个STTR I期项目将有助于在堪萨斯州创造技术工作，该地区很少有医疗或技术公司。该STTR I期项目建议开发商业验证证明的定向微波炉消融（MWA）涂抹器。 MWA程序为局部肿瘤和其他疾病提供了具有成本效益的微创治疗选择。这些治疗对大量的癌症患者尤其重要，这些癌症患者是手术或其他身体要求疗法的候选者。但是，当前可用的MWA系统会使用具有全向辐射模式的施用者，如果没有精确地放置可能会损害关键的健康组织或导致疾病复发。方向性MWA涂抹器可以促进技术和程序简化，以减轻这些当前的挑战。我们将研究：（1）缩小天线横截面的替代材料和（2）新型天线几何形状，以最大化定向微波炉消融区的大小。我们将采用一种方法来整合多物理计算模型，在体内组织中的台式实验以及体内动物模型中的实验来设计，优化和验证我们的设备。我们预期的技术结果是MWA施加器的开发，该涂抹器提供了对辐射模式的方向控制，该模式可以消融到30毫米的深度，从而产生与当前临床非方向性设备相当的消融量。该奖项反映了NSF的法规任务，并认为通过基金会的知识优点和广泛的criter criter scriter criter crietia criter criter criter criter criter criter criter criter criter criteria criter criteria criter criteria criteria crietia cristia award award a奖。